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Gene: ROMO1 |
Gene summary for ROMO1 |
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Gene information | Species | Human | Gene symbol | ROMO1 | Gene ID | 140823 |
Gene name | reactive oxygen species modulator 1 | |
Gene Alias | C20orf52 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P60602 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140823 | ROMO1 | S029 | Human | Liver | HCC | 1.38e-26 | 2.72e+00 | 0.2581 |
140823 | ROMO1 | C04 | Human | Oral cavity | OSCC | 3.34e-42 | 3.04e+00 | 0.2633 |
140823 | ROMO1 | C21 | Human | Oral cavity | OSCC | 1.94e-69 | 2.95e+00 | 0.2678 |
140823 | ROMO1 | C30 | Human | Oral cavity | OSCC | 4.91e-65 | 4.04e+00 | 0.3055 |
140823 | ROMO1 | C38 | Human | Oral cavity | OSCC | 2.60e-16 | 1.77e+00 | 0.172 |
140823 | ROMO1 | C43 | Human | Oral cavity | OSCC | 5.37e-87 | 1.73e+00 | 0.1704 |
140823 | ROMO1 | C46 | Human | Oral cavity | OSCC | 1.17e-35 | 1.11e+00 | 0.1673 |
140823 | ROMO1 | C51 | Human | Oral cavity | OSCC | 4.76e-41 | 2.28e+00 | 0.2674 |
140823 | ROMO1 | C57 | Human | Oral cavity | OSCC | 5.09e-64 | 2.23e+00 | 0.1679 |
140823 | ROMO1 | C06 | Human | Oral cavity | OSCC | 4.13e-17 | 2.17e+00 | 0.2699 |
140823 | ROMO1 | C07 | Human | Oral cavity | OSCC | 1.16e-17 | 2.67e+00 | 0.2491 |
140823 | ROMO1 | C08 | Human | Oral cavity | OSCC | 1.46e-74 | 1.91e+00 | 0.1919 |
140823 | ROMO1 | C09 | Human | Oral cavity | OSCC | 3.94e-51 | 1.83e+00 | 0.1431 |
140823 | ROMO1 | LN22 | Human | Oral cavity | OSCC | 4.04e-33 | 3.79e+00 | 0.1733 |
140823 | ROMO1 | LN38 | Human | Oral cavity | OSCC | 1.57e-07 | 1.32e+00 | 0.168 |
140823 | ROMO1 | LN46 | Human | Oral cavity | OSCC | 2.79e-13 | 1.05e+00 | 0.1666 |
140823 | ROMO1 | LP15 | Human | Oral cavity | LP | 1.31e-17 | 2.83e+00 | 0.2174 |
140823 | ROMO1 | LP17 | Human | Oral cavity | LP | 1.23e-11 | 2.33e+00 | 0.2349 |
140823 | ROMO1 | SYSMH1 | Human | Oral cavity | OSCC | 1.54e-62 | 1.84e+00 | 0.1127 |
140823 | ROMO1 | SYSMH2 | Human | Oral cavity | OSCC | 2.29e-30 | 1.55e+00 | 0.2326 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:19905427 | Breast | Precancer | mitochondrial transmembrane transport | 22/1080 | 102/18723 | 6.38e-08 | 3.80e-06 | 22 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00705858 | Breast | Precancer | protein localization to mitochondrion | 21/1080 | 125/18723 | 9.07e-06 | 2.42e-04 | 21 |
GO:00070066 | Breast | Precancer | mitochondrial membrane organization | 20/1080 | 116/18723 | 9.88e-06 | 2.61e-04 | 20 |
GO:00726558 | Breast | Precancer | establishment of protein localization to mitochondrion | 20/1080 | 120/18723 | 1.66e-05 | 4.03e-04 | 20 |
GO:00346149 | Breast | Precancer | cellular response to reactive oxygen species | 23/1080 | 155/18723 | 2.82e-05 | 6.31e-04 | 23 |
GO:00725938 | Breast | Precancer | reactive oxygen species metabolic process | 30/1080 | 239/18723 | 5.13e-05 | 1.07e-03 | 30 |
GO:00197307 | Breast | Precancer | antimicrobial humoral response | 19/1080 | 122/18723 | 7.02e-05 | 1.40e-03 | 19 |
GO:00618446 | Breast | Precancer | antimicrobial humoral immune response mediated by antimicrobial peptide | 14/1080 | 79/18723 | 1.53e-04 | 2.61e-03 | 14 |
GO:00901516 | Breast | Precancer | establishment of protein localization to mitochondrial membrane | 8/1080 | 30/18723 | 2.24e-04 | 3.40e-03 | 8 |
GO:00066268 | Breast | Precancer | protein targeting to mitochondrion | 15/1080 | 100/18723 | 5.94e-04 | 7.48e-03 | 15 |
GO:00066059 | Breast | Precancer | protein targeting | 33/1080 | 314/18723 | 6.50e-04 | 7.99e-03 | 33 |
GO:20003778 | Breast | Precancer | regulation of reactive oxygen species metabolic process | 20/1080 | 157/18723 | 7.19e-04 | 8.65e-03 | 20 |
GO:00725948 | Breast | Precancer | establishment of protein localization to organelle | 41/1080 | 422/18723 | 7.75e-04 | 9.20e-03 | 41 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROMO1 | SNV | Missense_Mutation | c.172N>G | p.Lys58Glu | p.K58E | P60602 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ROMO1 | SNV | Missense_Mutation | novel | c.142C>T | p.Arg48Trp | p.R48W | P60602 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ROMO1 | SNV | Missense_Mutation | novel | c.186N>C | p.Gln62His | p.Q62H | P60602 | protein_coding | deleterious(0.04) | benign(0.425) | TCGA-85-A4QQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ROMO1 | SNV | Missense_Mutation | rs749056787 | c.193N>A | p.Gly65Ser | p.G65S | P60602 | protein_coding | tolerated(0.16) | benign(0.056) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ROMO1 | SNV | Missense_Mutation | novel | c.37N>A | p.Pro13Thr | p.P13T | P60602 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-VQ-AA68-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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