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Gene: PIGR |
Gene summary for PIGR |
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Gene information | Species | Human | Gene symbol | PIGR | Gene ID | 5284 |
Gene name | polymeric immunoglobulin receptor | |
Gene Alias | PIGR | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001580 | UniProtAcc | P01833 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5284 | PIGR | P28T-E | Human | Esophagus | ESCC | 3.33e-43 | -7.93e-01 | 0.1149 |
5284 | PIGR | P30T-E | Human | Esophagus | ESCC | 5.34e-10 | -1.00e+00 | 0.137 |
5284 | PIGR | P31T-E | Human | Esophagus | ESCC | 2.08e-26 | -8.53e-01 | 0.1251 |
5284 | PIGR | P32T-E | Human | Esophagus | ESCC | 7.28e-26 | -1.00e+00 | 0.1666 |
5284 | PIGR | P36T-E | Human | Esophagus | ESCC | 4.16e-60 | -1.49e-01 | 0.1187 |
5284 | PIGR | P37T-E | Human | Esophagus | ESCC | 2.27e-17 | 4.92e-01 | 0.1371 |
5284 | PIGR | P38T-E | Human | Esophagus | ESCC | 2.26e-03 | -8.12e-01 | 0.127 |
5284 | PIGR | P39T-E | Human | Esophagus | ESCC | 5.17e-27 | -1.00e+00 | 0.0894 |
5284 | PIGR | P40T-E | Human | Esophagus | ESCC | 4.04e-16 | 3.82e-01 | 0.109 |
5284 | PIGR | P42T-E | Human | Esophagus | ESCC | 1.28e-16 | -1.00e+00 | 0.1175 |
5284 | PIGR | P44T-E | Human | Esophagus | ESCC | 2.30e-07 | 6.02e-01 | 0.1096 |
5284 | PIGR | P47T-E | Human | Esophagus | ESCC | 7.28e-26 | -1.00e+00 | 0.1067 |
5284 | PIGR | P48T-E | Human | Esophagus | ESCC | 2.66e-28 | 4.39e-01 | 0.0959 |
5284 | PIGR | P49T-E | Human | Esophagus | ESCC | 1.30e-02 | -1.00e+00 | 0.1768 |
5284 | PIGR | P52T-E | Human | Esophagus | ESCC | 5.95e-29 | -1.00e+00 | 0.1555 |
5284 | PIGR | P54T-E | Human | Esophagus | ESCC | 7.02e-24 | -7.34e-01 | 0.0975 |
5284 | PIGR | P57T-E | Human | Esophagus | ESCC | 1.68e-27 | 2.50e+00 | 0.0926 |
5284 | PIGR | P61T-E | Human | Esophagus | ESCC | 1.31e-23 | -1.00e+00 | 0.099 |
5284 | PIGR | P62T-E | Human | Esophagus | ESCC | 3.06e-29 | -9.87e-01 | 0.1302 |
5284 | PIGR | P65T-E | Human | Esophagus | ESCC | 1.80e-15 | -4.94e-02 | 0.0978 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018956 | Breast | Precancer | retina homeostasis | 12/1080 | 79/18723 | 1.82e-03 | 1.79e-02 | 12 |
GO:00018948 | Breast | Precancer | tissue homeostasis | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
GO:000189511 | Breast | IDC | retina homeostasis | 15/1434 | 79/18723 | 8.62e-04 | 1.00e-02 | 15 |
GO:000189413 | Breast | IDC | tissue homeostasis | 34/1434 | 268/18723 | 2.54e-03 | 2.28e-02 | 34 |
GO:000189521 | Breast | DCIS | retina homeostasis | 14/1390 | 79/18723 | 1.88e-03 | 1.81e-02 | 14 |
GO:000189423 | Breast | DCIS | tissue homeostasis | 33/1390 | 268/18723 | 2.88e-03 | 2.48e-02 | 33 |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00380933 | Cervix | CC | Fc receptor signaling pathway | 19/2311 | 50/18723 | 3.42e-06 | 9.17e-05 | 19 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:0002768 | Cervix | CC | immune response-regulating cell surface receptor signaling pathway | 59/2311 | 315/18723 | 6.64e-04 | 6.11e-03 | 59 |
GO:00018957 | Cervix | CC | retina homeostasis | 19/2311 | 79/18723 | 2.94e-03 | 1.94e-02 | 19 |
GO:00450565 | Cervix | CC | transcytosis | 7/2311 | 21/18723 | 1.04e-02 | 4.97e-02 | 7 |
GO:000276411 | Cervix | HSIL_HPV | immune response-regulating signaling pathway | 46/737 | 468/18723 | 1.17e-08 | 1.30e-06 | 46 |
GO:00027681 | Cervix | HSIL_HPV | immune response-regulating cell surface receptor signaling pathway | 32/737 | 315/18723 | 9.80e-07 | 4.68e-05 | 32 |
GO:000189512 | Cervix | HSIL_HPV | retina homeostasis | 12/737 | 79/18723 | 5.76e-05 | 1.39e-03 | 12 |
GO:000189414 | Cervix | HSIL_HPV | tissue homeostasis | 25/737 | 268/18723 | 6.17e-05 | 1.46e-03 | 25 |
GO:003809311 | Cervix | HSIL_HPV | Fc receptor signaling pathway | 8/737 | 50/18723 | 6.88e-04 | 9.21e-03 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046724 | Breast | DCIS | Intestinal immune network for IgA production | 11/846 | 49/8465 | 7.79e-03 | 3.60e-02 | 2.65e-02 | 11 |
hsa0467211 | Breast | DCIS | Intestinal immune network for IgA production | 11/846 | 49/8465 | 7.79e-03 | 3.60e-02 | 2.65e-02 | 11 |
hsa046725 | Cervix | HSIL_HPV | Intestinal immune network for IgA production | 10/459 | 49/8465 | 2.42e-04 | 2.53e-03 | 2.05e-03 | 10 |
hsa0467212 | Cervix | HSIL_HPV | Intestinal immune network for IgA production | 10/459 | 49/8465 | 2.42e-04 | 2.53e-03 | 2.05e-03 | 10 |
hsa0467221 | Cervix | N_HPV | Intestinal immune network for IgA production | 7/349 | 49/8465 | 3.68e-03 | 2.04e-02 | 1.60e-02 | 7 |
hsa0467231 | Cervix | N_HPV | Intestinal immune network for IgA production | 7/349 | 49/8465 | 3.68e-03 | 2.04e-02 | 1.60e-02 | 7 |
hsa04672 | Stomach | GC | Intestinal immune network for IgA production | 10/708 | 49/8465 | 6.45e-03 | 3.50e-02 | 2.46e-02 | 10 |
hsa046721 | Stomach | GC | Intestinal immune network for IgA production | 10/708 | 49/8465 | 6.45e-03 | 3.50e-02 | 2.46e-02 | 10 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIGR | SNV | Missense_Mutation | novel | c.860G>A | p.Gly287Glu | p.G287E | P01833 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
PIGR | SNV | Missense_Mutation | c.655N>G | p.Leu219Val | p.L219V | P01833 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |
PIGR | SNV | Missense_Mutation | c.116N>A | p.Thr39Lys | p.T39K | P01833 | protein_coding | tolerated(1) | benign(0.009) | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PIGR | SNV | Missense_Mutation | novel | c.2233G>A | p.Asp745Asn | p.D745N | P01833 | protein_coding | tolerated(0.05) | benign(0.105) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIGR | SNV | Missense_Mutation | novel | c.1324N>A | p.Leu442Met | p.L442M | P01833 | protein_coding | tolerated(0.3) | probably_damaging(0.988) | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PIGR | SNV | Missense_Mutation | c.2201N>T | p.Ser734Leu | p.S734L | P01833 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PIGR | SNV | Missense_Mutation | rs775192099 | c.2059G>A | p.Glu687Lys | p.E687K | P01833 | protein_coding | tolerated(0.09) | benign(0.063) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIGR | SNV | Missense_Mutation | c.137N>T | p.Ser46Phe | p.S46F | P01833 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGR | SNV | Missense_Mutation | rs767466182 | c.1747N>C | p.Asp583His | p.D583H | P01833 | protein_coding | tolerated(0.11) | benign(0.178) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PIGR | SNV | Missense_Mutation | c.2176N>G | p.Lys726Glu | p.K726E | P01833 | protein_coding | tolerated(1) | benign(0) | TCGA-E2-A1LS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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