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Gene: MRPL41 |
Gene summary for MRPL41 |
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Gene information | Species | Human | Gene symbol | MRPL41 | Gene ID | 64975 |
Gene name | mitochondrial ribosomal protein L41 | |
Gene Alias | BMRP | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q8IXM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64975 | MRPL41 | C09 | Human | Oral cavity | OSCC | 4.47e-34 | 1.25e+00 | 0.1431 |
64975 | MRPL41 | LN22 | Human | Oral cavity | OSCC | 2.74e-19 | 2.32e+00 | 0.1733 |
64975 | MRPL41 | LN38 | Human | Oral cavity | OSCC | 7.55e-15 | 2.09e+00 | 0.168 |
64975 | MRPL41 | LN46 | Human | Oral cavity | OSCC | 8.36e-14 | 1.19e+00 | 0.1666 |
64975 | MRPL41 | LP15 | Human | Oral cavity | LP | 2.42e-05 | 1.39e+00 | 0.2174 |
64975 | MRPL41 | LP17 | Human | Oral cavity | LP | 1.80e-02 | 1.14e+00 | 0.2349 |
64975 | MRPL41 | SYSMH1 | Human | Oral cavity | OSCC | 1.12e-47 | 1.37e+00 | 0.1127 |
64975 | MRPL41 | SYSMH2 | Human | Oral cavity | OSCC | 4.57e-41 | 1.93e+00 | 0.2326 |
64975 | MRPL41 | SYSMH3 | Human | Oral cavity | OSCC | 1.97e-48 | 1.94e+00 | 0.2442 |
64975 | MRPL41 | SYSMH4 | Human | Oral cavity | OSCC | 2.27e-11 | 4.02e-01 | 0.1226 |
64975 | MRPL41 | SYSMH5 | Human | Oral cavity | OSCC | 4.61e-09 | 4.97e-01 | 0.0647 |
64975 | MRPL41 | SYSMH6 | Human | Oral cavity | OSCC | 4.34e-23 | 1.22e+00 | 0.1275 |
64975 | MRPL41 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 3.29e-14 | 5.46e-01 | -0.1972 |
64975 | MRPL41 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 5.09e-04 | 3.63e-01 | -0.2126 |
64975 | MRPL41 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.74e-04 | 4.03e-01 | -0.1833 |
64975 | MRPL41 | 047563_1562-all-cells | Human | Prostate | BPH | 1.00e-17 | -3.40e-01 | 0.0791 |
64975 | MRPL41 | 048752_1579-all-cells | Human | Prostate | BPH | 1.44e-04 | -3.02e-01 | 0.1008 |
64975 | MRPL41 | 052097_1595-all-cells | Human | Prostate | BPH | 2.53e-07 | -3.60e-01 | 0.0972 |
64975 | MRPL41 | 052099_1652-all-cells | Human | Prostate | BPH | 1.44e-07 | -3.69e-01 | 0.1038 |
64975 | MRPL41 | Dong_P1 | Human | Prostate | Tumor | 2.53e-31 | 3.74e-01 | 0.035 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL41 | insertion | In_Frame_Ins | novel | c.250_251insGAG | p.Thr84delinsArgAla | p.T84delinsRA | Q8IXM3 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MRPL41 | SNV | Missense_Mutation | rs376218719 | c.156G>T | p.Gln52His | p.Q52H | Q8IXM3 | protein_coding | tolerated(0.12) | possibly_damaging(0.67) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | novel | c.352N>T | p.Gly118Cys | p.G118C | Q8IXM3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MRPL41 | SNV | Missense_Mutation | c.207N>T | p.Lys69Asn | p.K69N | Q8IXM3 | protein_coding | tolerated(0.08) | benign(0.045) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL41 | SNV | Missense_Mutation | rs773179110 | c.169N>A | p.Val57Ile | p.V57I | Q8IXM3 | protein_coding | tolerated(1) | benign(0.047) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | novel | c.296N>T | p.Ala99Val | p.A99V | Q8IXM3 | protein_coding | deleterious(0.02) | benign(0.412) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL41 | SNV | Missense_Mutation | c.307N>T | p.Asp103Tyr | p.D103Y | Q8IXM3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MRPL41 | SNV | Missense_Mutation | novel | c.275N>G | p.Phe92Cys | p.F92C | Q8IXM3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BA-6868-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
MRPL41 | SNV | Missense_Mutation | novel | c.358N>C | p.Glu120Gln | p.E120Q | Q8IXM3 | protein_coding | tolerated(0.06) | probably_damaging(0.979) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MRPL41 | SNV | Missense_Mutation | rs773179110 | c.169G>A | p.Val57Ile | p.V57I | Q8IXM3 | protein_coding | tolerated(1) | benign(0.047) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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