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Gene: MAL2 |
Gene summary for MAL2 |
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Gene information | Species | Human | Gene symbol | MAL2 | Gene ID | 114569 |
Gene name | mal, T cell differentiation protein 2 | |
Gene Alias | MAL2 | |
Cytomap | 8q24.12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R9E4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114569 | MAL2 | NAG_2 | Human | Stomach | CSG | 1.43e-02 | 2.08e-01 | -0.3324 |
114569 | MAL2 | NAG_3 | Human | Stomach | CSG | 2.99e-06 | -4.66e-01 | -0.2816 |
114569 | MAL2 | CAG_1 | Human | Stomach | CAG | 1.39e-03 | -7.31e-01 | -0.3206 |
114569 | MAL2 | CAG_2 | Human | Stomach | CAG | 8.87e-08 | -4.32e-01 | -0.2831 |
114569 | MAL2 | CAG_3 | Human | Stomach | CAG | 5.52e-17 | -3.87e-01 | -0.2766 |
114569 | MAL2 | WIM_1 | Human | Stomach | WIM | 3.33e-06 | -6.06e-01 | 0.0335 |
114569 | MAL2 | WIM_2 | Human | Stomach | WIM | 4.43e-07 | -6.99e-01 | 0.1159 |
114569 | MAL2 | SIM_1 | Human | Stomach | SIM | 1.36e-17 | -7.35e-01 | 0.3573 |
114569 | MAL2 | SIM_2 | Human | Stomach | SIM | 8.47e-20 | -7.38e-01 | 0.3139 |
114569 | MAL2 | SIM_3 | Human | Stomach | SIM | 1.46e-07 | -4.61e-01 | 0.0345 |
114569 | MAL2 | EGC | Human | Stomach | GC | 3.80e-10 | -5.83e-01 | 0.1683 |
114569 | MAL2 | Pt1_Superficial | Human | Stomach | GC | 4.25e-05 | -5.98e-01 | 0.1036 |
114569 | MAL2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 2.18e-22 | -7.32e-01 | 0.02 |
114569 | MAL2 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 8.90e-11 | -6.57e-01 | 0.0267 |
114569 | MAL2 | PTCwithHT_1 | Human | Thyroid | HT | 1.32e-06 | -7.32e-01 | 0.0238 |
114569 | MAL2 | PTCwithHT_6 | Human | Thyroid | HT | 6.69e-12 | -6.84e-01 | 0.02 |
114569 | MAL2 | PTCwithHT_8 | Human | Thyroid | HT | 2.25e-17 | -6.80e-01 | 0.0351 |
114569 | MAL2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 8.97e-14 | -6.61e-01 | 0.0419 |
114569 | MAL2 | PTCwithoutHT_7 | Human | Thyroid | PTC | 2.06e-02 | -5.76e-01 | 0.0381 |
114569 | MAL2 | male-WTA | Human | Thyroid | PTC | 1.18e-68 | 9.97e-02 | 0.1037 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00450565 | Cervix | CC | transcytosis | 7/2311 | 21/18723 | 1.04e-02 | 4.97e-02 | 7 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00450568 | Esophagus | ESCC | transcytosis | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00450564 | Liver | Cirrhotic | transcytosis | 12/4634 | 21/18723 | 1.53e-03 | 9.98e-03 | 12 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:004505611 | Liver | HCC | transcytosis | 15/7958 | 21/18723 | 7.03e-03 | 2.80e-02 | 15 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00450567 | Oral cavity | OSCC | transcytosis | 16/7305 | 21/18723 | 5.99e-04 | 3.39e-03 | 16 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:004505613 | Oral cavity | LP | transcytosis | 11/4623 | 21/18723 | 5.78e-03 | 3.44e-02 | 11 |
GO:00450566 | Prostate | BPH | transcytosis | 10/3107 | 21/18723 | 9.32e-04 | 5.91e-03 | 10 |
GO:004505612 | Prostate | Tumor | transcytosis | 10/3246 | 21/18723 | 1.33e-03 | 8.31e-03 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAL2 | SNV | Missense_Mutation | novel | c.181C>G | p.Leu61Val | p.L61V | Q969L2 | protein_coding | tolerated(0.68) | benign(0.248) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MAL2 | deletion | Frame_Shift_Del | novel | c.158delT | p.Leu53TrpfsTer21 | p.L53Wfs*21 | Q969L2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MAL2 | SNV | Missense_Mutation | novel | c.182N>C | p.Leu61Pro | p.L61P | Q969L2 | protein_coding | tolerated(0.1) | probably_damaging(0.993) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAL2 | SNV | Missense_Mutation | novel | c.220N>T | p.Thr74Ser | p.T74S | Q969L2 | protein_coding | tolerated(0.17) | benign(0.171) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MAL2 | SNV | Missense_Mutation | novel | c.407N>T | p.Thr136Ile | p.T136I | Q969L2 | protein_coding | tolerated(0.25) | benign(0.025) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MAL2 | SNV | Missense_Mutation | novel | c.281N>A | p.Ile94Asn | p.I94N | Q969L2 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAL2 | SNV | Missense_Mutation | novel | c.406N>C | p.Thr136Pro | p.T136P | Q969L2 | protein_coding | tolerated(0.17) | benign(0.114) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAL2 | SNV | Missense_Mutation | novel | c.472A>G | p.Met158Val | p.M158V | Q969L2 | protein_coding | tolerated(1) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MAL2 | SNV | Missense_Mutation | novel | c.153N>T | p.Trp51Cys | p.W51C | Q969L2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAL2 | SNV | Missense_Mutation | rs749996607 | c.374N>G | p.Ser125Cys | p.S125C | Q969L2 | protein_coding | tolerated(0.06) | probably_damaging(0.954) | TCGA-34-5928-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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