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Gene: LGALS3 |
Gene summary for LGALS3 |
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Gene information | Species | Human | Gene symbol | LGALS3 | Gene ID | 3958 |
Gene name | galectin 3 | |
Gene Alias | CBP35 | |
Cytomap | 14q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001771 | UniProtAcc | A0A024R693 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3958 | LGALS3 | P57T-E | Human | Esophagus | ESCC | 2.70e-47 | 2.32e+00 | 0.0926 |
3958 | LGALS3 | P61T-E | Human | Esophagus | ESCC | 9.92e-29 | 2.01e+00 | 0.099 |
3958 | LGALS3 | P62T-E | Human | Esophagus | ESCC | 1.17e-25 | 1.79e+00 | 0.1302 |
3958 | LGALS3 | P65T-E | Human | Esophagus | ESCC | 2.56e-48 | 2.46e+00 | 0.0978 |
3958 | LGALS3 | P74T-E | Human | Esophagus | ESCC | 6.57e-38 | 3.16e+00 | 0.1479 |
3958 | LGALS3 | P75T-E | Human | Esophagus | ESCC | 3.16e-66 | 4.56e+00 | 0.1125 |
3958 | LGALS3 | P76T-E | Human | Esophagus | ESCC | 1.63e-10 | 1.29e+00 | 0.1207 |
3958 | LGALS3 | P80T-E | Human | Esophagus | ESCC | 5.14e-21 | 1.30e+00 | 0.155 |
3958 | LGALS3 | P82T-E | Human | Esophagus | ESCC | 3.07e-23 | 3.84e+00 | 0.1072 |
3958 | LGALS3 | P83T-E | Human | Esophagus | ESCC | 1.60e-24 | 2.45e+00 | 0.1738 |
3958 | LGALS3 | P84T-E | Human | Esophagus | ESCC | 9.12e-12 | 3.19e+00 | 0.0933 |
3958 | LGALS3 | P89T-E | Human | Esophagus | ESCC | 2.40e-26 | 3.36e+00 | 0.1752 |
3958 | LGALS3 | P91T-E | Human | Esophagus | ESCC | 1.65e-20 | 3.12e+00 | 0.1828 |
3958 | LGALS3 | P94T-E | Human | Esophagus | ESCC | 2.92e-15 | 2.69e+00 | 0.0879 |
3958 | LGALS3 | P104T-E | Human | Esophagus | ESCC | 1.79e-04 | 1.98e+00 | 0.0931 |
3958 | LGALS3 | P107T-E | Human | Esophagus | ESCC | 2.18e-56 | 2.62e+00 | 0.171 |
3958 | LGALS3 | P126T-E | Human | Esophagus | ESCC | 1.21e-13 | 3.26e+00 | 0.1125 |
3958 | LGALS3 | P127T-E | Human | Esophagus | ESCC | 1.13e-30 | 2.40e+00 | 0.0826 |
3958 | LGALS3 | P128T-E | Human | Esophagus | ESCC | 1.88e-20 | 3.13e+00 | 0.1241 |
3958 | LGALS3 | P130T-E | Human | Esophagus | ESCC | 5.51e-86 | 3.28e+00 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00716217 | Breast | Precancer | granulocyte chemotaxis | 23/1080 | 125/18723 | 6.73e-07 | 2.77e-05 | 23 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:00975307 | Breast | Precancer | granulocyte migration | 24/1080 | 148/18723 | 4.04e-06 | 1.26e-04 | 24 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00305937 | Breast | Precancer | neutrophil chemotaxis | 19/1080 | 103/18723 | 5.94e-06 | 1.71e-04 | 19 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:19902665 | Breast | Precancer | neutrophil migration | 20/1080 | 122/18723 | 2.13e-05 | 4.99e-04 | 20 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00508637 | Breast | Precancer | regulation of T cell activation | 37/1080 | 329/18723 | 8.04e-05 | 1.56e-03 | 37 |
GO:00071597 | Breast | Precancer | leukocyte cell-cell adhesion | 40/1080 | 371/18723 | 1.07e-04 | 1.94e-03 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS3 | SNV | Missense_Mutation | c.649C>T | p.His217Tyr | p.H217Y | P17931 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | c.594C>G | p.Phe198Leu | p.F198L | P17931 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
LGALS3 | SNV | Missense_Mutation | novel | c.734N>T | p.Ala245Val | p.A245V | P17931 | protein_coding | tolerated(1) | benign(0.044) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGALS3 | SNV | Missense_Mutation | c.193N>A | p.Gly65Arg | p.G65R | P17931 | protein_coding | deleterious(0) | possibly_damaging(0.619) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | c.182N>A | p.Gly61Asp | p.G61D | P17931 | protein_coding | deleterious(0.03) | possibly_damaging(0.684) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | rs201398647 | c.386N>A | p.Arg129His | p.R129H | P17931 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGALS3 | SNV | Missense_Mutation | c.695G>A | p.Ser232Asn | p.S232N | P17931 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS3 | SNV | Missense_Mutation | novel | c.367N>T | p.Pro123Ser | p.P123S | P17931 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS3 | deletion | Frame_Shift_Del | novel | c.152delC | p.Pro51GlnfsTer64 | p.P51Qfs*64 | P17931 | protein_coding | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LGALS3 | SNV | Missense_Mutation | novel | c.38N>T | p.Gly13Val | p.G13V | P17931 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | LACTOSE, ANHYDROUS | LACTOSE, ANHYDROUS | 21524586 | |
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | GR-MD-02 | BELAPECTIN | ||
3958 | LGALS3 | CELL SURFACE, DRUGGABLE GENOME | Antibiotics | 25869013 |
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