|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: KTN1 |
Gene summary for KTN1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KTN1 | Gene ID | 3895 |
| Gene name | kinectin 1 | |
| Gene Alias | CG1 | |
| Cytomap | 14q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R663 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3895 | KTN1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.16e-10 | 6.29e-01 | 0.3371 |
| 3895 | KTN1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.42e-05 | 4.76e-01 | 0.343 |
| 3895 | KTN1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 2.03e-05 | 5.02e-01 | 0.3385 |
| 3895 | KTN1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.39e-08 | 4.57e-01 | 0.3329 |
| 3895 | KTN1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.45e-13 | 4.40e-01 | -0.2116 |
| 3895 | KTN1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.05e-07 | 4.96e-01 | -0.1941 |
| 3895 | KTN1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.13e-03 | 3.97e-01 | -0.2107 |
| 3895 | KTN1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.06e-13 | 6.10e-01 | -0.2119 |
| 3895 | KTN1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 3.86e-03 | 3.92e-01 | 0.1829 |
| 3895 | KTN1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 3.44e-02 | 2.56e-01 | 0.1835 |
| 3895 | KTN1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 5.84e-07 | 5.44e-01 | 0.1859 |
| 3895 | KTN1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 8.15e-13 | 3.48e-01 | -0.0166 |
| 3895 | KTN1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.10e-20 | 4.01e-01 | -0.0132 |
| 3895 | KTN1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.76e-23 | 4.19e-01 | -0.013 |
| 3895 | KTN1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 7.65e-12 | 2.62e-01 | -0.0121 |
| 3895 | KTN1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 8.59e-08 | 4.80e-01 | -0.0961 |
| 3895 | KTN1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.63e-08 | 5.58e-01 | -0.0876 |
| 3895 | KTN1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.62e-10 | 6.64e-01 | -0.0822 |
| 3895 | KTN1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.12e-12 | 6.66e-01 | -0.0809 |
| 3895 | KTN1 | C04 | Human | Oral cavity | OSCC | 2.42e-41 | 2.86e+00 | 0.2633 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KTN1 | SNV | Missense_Mutation | c.3131N>T | p.Ala1044Val | p.A1044V | Q86UP2 | protein_coding | tolerated(0.08) | benign(0.409) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KTN1 | SNV | Missense_Mutation | c.856N>C | p.Asp286His | p.D286H | Q86UP2 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| KTN1 | SNV | Missense_Mutation | novel | c.2261G>A | p.Gly754Glu | p.G754E | Q86UP2 | protein_coding | tolerated(0.19) | probably_damaging(1) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
| KTN1 | SNV | Missense_Mutation | novel | c.183N>T | p.Lys61Asn | p.K61N | Q86UP2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| KTN1 | SNV | Missense_Mutation | c.2381N>T | p.Ser794Phe | p.S794F | Q86UP2 | protein_coding | deleterious(0.01) | possibly_damaging(0.784) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| KTN1 | SNV | Missense_Mutation | c.3433G>C | p.Glu1145Gln | p.E1145Q | Q86UP2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| KTN1 | SNV | Missense_Mutation | novel | c.860N>G | p.Phe287Cys | p.F287C | Q86UP2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KTN1 | SNV | Missense_Mutation | c.157N>C | p.Asp53His | p.D53H | Q86UP2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| KTN1 | SNV | Missense_Mutation | c.1693G>C | p.Glu565Gln | p.E565Q | Q86UP2 | protein_coding | deleterious(0.01) | possibly_damaging(0.571) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
| KTN1 | SNV | Missense_Mutation | rs773402721 | c.2757N>C | p.Leu919Phe | p.L919F | Q86UP2 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |