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Gene: HNRNPH1 |
Gene summary for HNRNPH1 |
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Gene information | Species | Human | Gene symbol | HNRNPH1 | Gene ID | 3187 |
Gene name | heterogeneous nuclear ribonucleoprotein H1 | |
Gene Alias | HNRPH | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P31943 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3187 | HNRNPH1 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 4.29e-04 | 6.85e-01 | -0.2027 |
3187 | HNRNPH1 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 1.77e-12 | 6.99e-01 | -0.1833 |
3187 | HNRNPH1 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 5.39e-10 | 6.57e-01 | -0.23 |
3187 | HNRNPH1 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 4.53e-11 | 8.14e-01 | -0.23 |
3187 | HNRNPH1 | 047563_1562-all-cells | Human | Prostate | BPH | 1.98e-17 | 2.35e-01 | 0.0791 |
3187 | HNRNPH1 | 048752_1579-all-cells | Human | Prostate | BPH | 5.80e-08 | 3.42e-02 | 0.1008 |
3187 | HNRNPH1 | 052095_1628-all-cells | Human | Prostate | BPH | 1.07e-05 | 3.08e-01 | 0.1032 |
3187 | HNRNPH1 | 052097_1595-all-cells | Human | Prostate | BPH | 2.26e-02 | 1.71e-01 | 0.0972 |
3187 | HNRNPH1 | Dong_P1 | Human | Prostate | Tumor | 1.81e-18 | 1.43e-01 | 0.035 |
3187 | HNRNPH1 | Dong_P3 | Human | Prostate | Tumor | 1.73e-09 | 3.56e-01 | 0.0278 |
3187 | HNRNPH1 | Dong_P4 | Human | Prostate | Tumor | 6.29e-03 | 2.55e-01 | 0.0292 |
3187 | HNRNPH1 | Dong_P5 | Human | Prostate | Tumor | 8.07e-26 | 4.03e-03 | 0.053 |
3187 | HNRNPH1 | P7 | Human | Prostate | Tumor | 1.24e-05 | 8.02e-01 | -0.1025 |
3187 | HNRNPH1 | P10 | Human | Prostate | Tumor | 1.27e-06 | 8.41e-01 | -0.0902 |
3187 | HNRNPH1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.74e-09 | -3.00e-01 | 0.1545 |
3187 | HNRNPH1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 3.91e-08 | -3.41e-01 | 0.1569 |
3187 | HNRNPH1 | P1_S1_AK | Human | Skin | AK | 5.48e-09 | -2.84e-01 | -0.3399 |
3187 | HNRNPH1 | P2_S3_AK | Human | Skin | AK | 1.25e-11 | -3.70e-01 | -0.3287 |
3187 | HNRNPH1 | P2_S4_SCCIS | Human | Skin | SCCIS | 1.12e-03 | -2.49e-01 | -0.3043 |
3187 | HNRNPH1 | P4_S8_cSCC | Human | Skin | cSCC | 1.58e-15 | -1.77e-01 | -0.3095 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:004348424 | Breast | DCIS | regulation of RNA splicing | 36/1390 | 148/18723 | 1.40e-10 | 1.69e-08 | 36 |
GO:000037524 | Breast | DCIS | RNA splicing, via transesterification reactions | 58/1390 | 324/18723 | 2.89e-10 | 3.34e-08 | 58 |
GO:000037724 | Breast | DCIS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:000039824 | Breast | DCIS | mRNA splicing, via spliceosome | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:000037710 | Cervix | CC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000039810 | Cervix | CC | mRNA splicing, via spliceosome | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000037510 | Cervix | CC | RNA splicing, via transesterification reactions | 55/2311 | 324/18723 | 8.61e-03 | 4.44e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPH1 | SNV | Missense_Mutation | c.1196N>A | p.Gly399Asp | p.G399D | P31943 | protein_coding | tolerated(0.06) | benign(0.188) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1114N>A | p.Tyr372Asn | p.Y372N | P31943 | protein_coding | tolerated(0.11) | benign(0) | TCGA-E2-A15O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | PD |
HNRNPH1 | insertion | Nonsense_Mutation | novel | c.1179_1180insCTCTGGCTTGGCAGTTGAGGCTGTTGCG | p.Ser394LeufsTer6 | p.S394Lfs*6 | P31943 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
HNRNPH1 | SNV | Missense_Mutation | c.617G>A | p.Arg206Gln | p.R206Q | P31943 | protein_coding | tolerated(0.09) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1327N>A | p.Asp443Asn | p.D443N | P31943 | protein_coding | tolerated_low_confidence(0.59) | benign(0) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
HNRNPH1 | SNV | Missense_Mutation | c.16G>A | p.Glu6Lys | p.E6K | P31943 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1103G>T | p.Ser368Ile | p.S368I | P31943 | protein_coding | deleterious(0.04) | benign(0.208) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
HNRNPH1 | SNV | Missense_Mutation | c.616C>T | p.Arg206Trp | p.R206W | P31943 | protein_coding | tolerated(0.05) | benign(0.02) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.211N>A | p.Leu71Met | p.L71M | P31943 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPH1 | SNV | Missense_Mutation | c.1188N>T | p.Met396Ile | p.M396I | P31943 | protein_coding | tolerated(0.69) | benign(0.104) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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