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Gene: FAF1 |
Gene summary for FAF1 |
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Gene information | Species | Human | Gene symbol | FAF1 | Gene ID | 11124 |
Gene name | Fas associated factor 1 | |
Gene Alias | CGI-03 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UNN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11124 | FAF1 | 047563_1562-all-cells | Human | Prostate | BPH | 1.69e-04 | 3.12e-01 | 0.0791 |
11124 | FAF1 | 048752_1579-all-cells | Human | Prostate | BPH | 4.67e-27 | 6.23e-01 | 0.1008 |
11124 | FAF1 | 052095_1628-all-cells | Human | Prostate | BPH | 1.24e-22 | 5.93e-01 | 0.1032 |
11124 | FAF1 | 052097_1595-all-cells | Human | Prostate | BPH | 2.94e-16 | 4.48e-01 | 0.0972 |
11124 | FAF1 | 052099_1652-all-cells | Human | Prostate | BPH | 1.93e-21 | 5.33e-01 | 0.1038 |
11124 | FAF1 | Dong_P1 | Human | Prostate | Tumor | 7.78e-05 | -1.90e-02 | 0.035 |
11124 | FAF1 | Dong_P3 | Human | Prostate | Tumor | 3.41e-03 | 1.99e-03 | 0.0278 |
11124 | FAF1 | Dong_P4 | Human | Prostate | Tumor | 3.47e-03 | 1.21e-01 | 0.0292 |
11124 | FAF1 | Dong_P5 | Human | Prostate | Tumor | 8.11e-08 | -3.50e-02 | 0.053 |
11124 | FAF1 | P1_S1_AK | Human | Skin | AK | 1.96e-40 | 7.65e-01 | -0.3399 |
11124 | FAF1 | P2_S3_AK | Human | Skin | AK | 6.53e-30 | 6.38e-01 | -0.3287 |
11124 | FAF1 | P2_S4_SCCIS | Human | Skin | SCCIS | 3.57e-18 | 5.11e-01 | -0.3043 |
11124 | FAF1 | P3_S6_AK | Human | Skin | AK | 7.55e-33 | 7.84e-01 | -0.3256 |
11124 | FAF1 | P4_S8_cSCC | Human | Skin | cSCC | 1.17e-37 | 7.55e-01 | -0.3095 |
11124 | FAF1 | P5_S10_cSCC | Human | Skin | cSCC | 3.38e-59 | 8.03e-01 | -0.299 |
11124 | FAF1 | P1_cSCC | Human | Skin | cSCC | 5.03e-10 | 4.68e-01 | 0.0292 |
11124 | FAF1 | P2_cSCC | Human | Skin | cSCC | 9.03e-09 | 3.01e-01 | -0.024 |
11124 | FAF1 | P4_cSCC | Human | Skin | cSCC | 3.17e-09 | 2.53e-01 | -0.00290000000000005 |
11124 | FAF1 | P10_cSCC | Human | Skin | cSCC | 4.94e-13 | 4.17e-01 | 0.1017 |
11124 | FAF1 | Pat01-B | Human | Stomach | GC | 2.48e-08 | 2.52e-01 | 0.5754 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:20012357 | Cervix | CC | positive regulation of apoptotic signaling pathway | 37/2311 | 126/18723 | 2.70e-07 | 1.12e-05 | 37 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:003133410 | Cervix | CC | positive regulation of protein-containing complex assembly | 55/2311 | 237/18723 | 2.25e-06 | 6.73e-05 | 55 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:200123610 | Cervix | CC | regulation of extrinsic apoptotic signaling pathway | 37/2311 | 151/18723 | 2.80e-05 | 4.65e-04 | 37 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:20012386 | Cervix | CC | positive regulation of extrinsic apoptotic signaling pathway | 14/2311 | 48/18723 | 1.48e-03 | 1.15e-02 | 14 |
GO:00457404 | Cervix | CC | positive regulation of DNA replication | 12/2311 | 40/18723 | 2.44e-03 | 1.71e-02 | 12 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAF1 | SNV | Missense_Mutation | c.1948G>C | p.Glu650Gln | p.E650Q | Q9UNN5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.954) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAF1 | SNV | Missense_Mutation | novel | c.164A>C | p.Glu55Ala | p.E55A | Q9UNN5 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.1639N>C | p.Glu547Gln | p.E547Q | Q9UNN5 | protein_coding | tolerated(0.14) | probably_damaging(0.996) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | c.604N>A | p.Glu202Lys | p.E202K | Q9UNN5 | protein_coding | tolerated(0.77) | benign(0.164) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | novel | c.1479A>T | p.Glu493Asp | p.E493D | Q9UNN5 | protein_coding | tolerated(0.57) | benign(0.072) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAF1 | insertion | Frame_Shift_Ins | novel | c.1597_1598insGA | p.Met533ArgfsTer26 | p.M533Rfs*26 | Q9UNN5 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAF1 | SNV | Missense_Mutation | novel | c.1647A>C | p.Glu549Asp | p.E549D | Q9UNN5 | protein_coding | tolerated(0.11) | possibly_damaging(0.679) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.1498N>A | p.Glu500Lys | p.E500K | Q9UNN5 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AD-6963-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | c.1805T>G | p.Phe602Cys | p.F602C | Q9UNN5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | novel | c.571N>C | p.Asn191His | p.N191H | Q9UNN5 | protein_coding | tolerated(0.2) | possibly_damaging(0.453) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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