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Gene: C8orf59 |
Gene summary for C8ORF59 |
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Gene information | Species | Human | Gene symbol | C8orf59 | Gene ID | 401466 |
Gene name | ribosomal biogenesis factor | |
Gene Alias | C8orf59 | |
Cytomap | 8q21.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R838 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401466 | C8orf59 | cSCC_p4 | Human | Skin | cSCC | 2.54e-08 | 2.68e-01 | -0.2022 |
401466 | C8orf59 | cSCC_p6 | Human | Skin | cSCC | 1.10e-10 | 3.67e-01 | -0.1989 |
401466 | C8orf59 | cSCC_p8 | Human | Skin | cSCC | 2.55e-22 | 4.24e-01 | -0.1971 |
401466 | C8orf59 | cSCC_p9 | Human | Skin | cSCC | 3.20e-21 | 4.22e-01 | -0.1991 |
401466 | C8orf59 | Pat01-B | Human | Stomach | GC | 1.36e-22 | -6.47e-01 | 0.5754 |
401466 | C8orf59 | Pat02-B | Human | Stomach | GC | 8.97e-18 | -6.47e-01 | 0.0368 |
401466 | C8orf59 | Pat03-B | Human | Stomach | GC | 4.87e-19 | -6.47e-01 | 0.3693 |
401466 | C8orf59 | Pat04-B | Human | Stomach | GC | 4.06e-09 | -6.47e-01 | -0.1483 |
401466 | C8orf59 | Pat05-B | Human | Stomach | GC | 2.78e-08 | -6.47e-01 | -0.0353 |
401466 | C8orf59 | Pat06-B | Human | Stomach | GC | 5.70e-19 | -6.47e-01 | -0.1961 |
401466 | C8orf59 | Pat07-B | Human | Stomach | GC | 2.17e-04 | -6.47e-01 | 0.0935 |
401466 | C8orf59 | Pat08-B | Human | Stomach | GC | 7.70e-07 | -6.47e-01 | 0.0182 |
401466 | C8orf59 | Pat09-B | Human | Stomach | GC | 4.78e-16 | -6.47e-01 | -0.0359 |
401466 | C8orf59 | Pat10-B | Human | Stomach | GC | 3.55e-04 | -6.47e-01 | 0.084 |
401466 | C8orf59 | Pat11-B | Human | Stomach | GC | 2.50e-07 | -6.47e-01 | -0.182 |
401466 | C8orf59 | Pat12-B | Human | Stomach | GC | 1.43e-20 | -6.47e-01 | 0.0325 |
401466 | C8orf59 | Pat13-B | Human | Stomach | GC | 1.49e-10 | -6.47e-01 | 0.0555 |
401466 | C8orf59 | Pat15-B | Human | Stomach | GC | 6.74e-16 | -6.47e-01 | -0.0778 |
401466 | C8orf59 | Pat16-B | Human | Stomach | GC | 8.97e-18 | -6.47e-01 | 0.1918 |
401466 | C8orf59 | Pat17-B | Human | Stomach | GC | 2.05e-17 | -6.47e-01 | 0.3109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C8orf59 | SNV | Missense_Mutation | c.114N>T | p.Lys38Asn | p.K38N | Q8N0T1 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C8orf59 | SNV | Missense_Mutation | novel | c.67N>G | p.Phe23Val | p.F23V | Q8N0T1 | protein_coding | tolerated(0.15) | benign(0.031) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C8orf59 | deletion | Frame_Shift_Del | rs752886571 | c.65delN | p.Asn22ThrfsTer18 | p.N22Tfs*18 | Q8N0T1 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C8orf59 | SNV | Missense_Mutation | c.68N>G | p.Phe23Cys | p.F23C | Q8N0T1 | protein_coding | deleterious(0.03) | possibly_damaging(0.794) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C8orf59 | SNV | Missense_Mutation | novel | c.235N>T | p.Pro79Ser | p.P79S | Q8N0T1 | protein_coding | tolerated(0.45) | benign(0.027) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf59 | SNV | Missense_Mutation | novel | c.116N>C | p.Ile39Thr | p.I39T | Q8N0T1 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C8orf59 | SNV | Missense_Mutation | novel | c.41T>C | p.Val14Ala | p.V14A | Q8N0T1 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C8orf59 | SNV | Missense_Mutation | novel | c.168N>A | p.Asn56Lys | p.N56K | Q8N0T1 | protein_coding | deleterious(0.05) | benign(0.053) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C8orf59 | SNV | Missense_Mutation | novel | c.197A>T | p.Lys66Ile | p.K66I | Q8N0T1 | protein_coding | deleterious(0) | possibly_damaging(0.509) | TCGA-BA-4075-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
C8orf59 | SNV | Missense_Mutation | novel | c.275N>G | p.Glu92Gly | p.E92G | Q8N0T1 | protein_coding | tolerated(0.14) | possibly_damaging(0.523) | TCGA-CV-6948-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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