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Gene: ATP5D |
Gene summary for ATP5D |
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Gene information | Species | Human | Gene symbol | ATP5D | Gene ID | 513 |
Gene name | ATP synthase F1 subunit delta | |
Gene Alias | ATP5D | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P30049 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
513 | ATP5D | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 8.70e-06 | 2.85e-01 | 0.1604 |
513 | ATP5D | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 6.87e-04 | 2.28e-01 | 0.1621 |
513 | ATP5D | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.14e-05 | 2.96e-01 | 0.1575 |
513 | ATP5D | P1_S1_AK | Human | Skin | AK | 1.70e-22 | -4.61e-01 | -0.3399 |
513 | ATP5D | P2_S3_AK | Human | Skin | AK | 1.70e-22 | -4.61e-01 | -0.3287 |
513 | ATP5D | P2_S4_SCCIS | Human | Skin | SCCIS | 7.20e-23 | -4.61e-01 | -0.3043 |
513 | ATP5D | P3_S6_AK | Human | Skin | AK | 3.04e-23 | -4.61e-01 | -0.3256 |
513 | ATP5D | P4_S8_cSCC | Human | Skin | cSCC | 2.55e-12 | -4.61e-01 | -0.3095 |
513 | ATP5D | P5_S10_cSCC | Human | Skin | cSCC | 1.28e-23 | -4.61e-01 | -0.299 |
513 | ATP5D | P1_cSCC | Human | Skin | cSCC | 8.83e-71 | 2.89e+00 | 0.0292 |
513 | ATP5D | P2_cSCC | Human | Skin | cSCC | 2.36e-83 | 2.15e+00 | -0.024 |
513 | ATP5D | P4_cSCC | Human | Skin | cSCC | 1.07e-86 | 2.40e+00 | -0.00290000000000005 |
513 | ATP5D | P10_cSCC | Human | Skin | cSCC | 1.05e-72 | 2.38e+00 | 0.1017 |
513 | ATP5D | cSCC_p1 | Human | Skin | cSCC | 1.20e-13 | 5.27e-01 | -0.1916 |
513 | ATP5D | cSCC_p10 | Human | Skin | cSCC | 3.75e-21 | 6.96e-01 | -0.2095 |
513 | ATP5D | cSCC_p11 | Human | Skin | cSCC | 2.11e-17 | 5.66e-01 | -0.2102 |
513 | ATP5D | cSCC_p3 | Human | Skin | cSCC | 2.08e-11 | 5.10e-01 | -0.2085 |
513 | ATP5D | cSCC_p4 | Human | Skin | cSCC | 1.21e-29 | 6.97e-01 | -0.2022 |
513 | ATP5D | cSCC_p6 | Human | Skin | cSCC | 4.62e-16 | 6.05e-01 | -0.1989 |
513 | ATP5D | cSCC_p7 | Human | Skin | cSCC | 6.15e-13 | 4.11e-01 | -0.2332 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5D | SNV | Missense_Mutation | c.217N>T | p.His73Tyr | p.H73Y | P30049 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP5D | SNV | Missense_Mutation | rs781350269 | c.416C>T | p.Ala139Val | p.A139V | P30049 | protein_coding | deleterious(0.01) | benign(0.284) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5D | SNV | Missense_Mutation | c.217C>T | p.His73Tyr | p.H73Y | P30049 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AH-6644-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP5D | SNV | Missense_Mutation | rs753537314 | c.349N>A | p.Glu117Lys | p.E117K | P30049 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ATP5D | SNV | Missense_Mutation | novel | c.196N>A | p.Ala66Thr | p.A66T | P30049 | protein_coding | tolerated(0.17) | benign(0.02) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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