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Gene: ZFAND3 |
Gene summary for ZFAND3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZFAND3 | Gene ID | 60685 |
| Gene name | zinc finger AN1-type containing 3 | |
| Gene Alias | TEX27 | |
| Cytomap | 6p21.2 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024RD12 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 60685 | ZFAND3 | CCI_1 | Human | Cervix | CC | 2.55e-22 | 2.23e+00 | 0.528 |
| 60685 | ZFAND3 | CCI_2 | Human | Cervix | CC | 2.67e-20 | 2.36e+00 | 0.5249 |
| 60685 | ZFAND3 | CCI_3 | Human | Cervix | CC | 5.86e-34 | 2.15e+00 | 0.516 |
| 60685 | ZFAND3 | CCII_1 | Human | Cervix | CC | 9.86e-04 | 4.38e-01 | 0.3249 |
| 60685 | ZFAND3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.72e-08 | -3.58e-01 | 0.0155 |
| 60685 | ZFAND3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.63e-05 | 4.78e-01 | -0.0811 |
| 60685 | ZFAND3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.38e-23 | 8.25e-01 | -0.1954 |
| 60685 | ZFAND3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.01e-07 | 8.02e-01 | -0.2602 |
| 60685 | ZFAND3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.53e-05 | 6.26e-01 | -0.2196 |
| 60685 | ZFAND3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.15e-03 | 4.51e-01 | -0.1526 |
| 60685 | ZFAND3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.73e-07 | 6.87e-01 | -0.059 |
| 60685 | ZFAND3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.27e-06 | -3.00e-01 | 0.0528 |
| 60685 | ZFAND3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.25e-09 | 7.38e-01 | 0.3487 |
| 60685 | ZFAND3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.45e-14 | 7.80e-01 | 0.281 |
| 60685 | ZFAND3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.12e-03 | -3.08e-01 | 0.3005 |
| 60685 | ZFAND3 | A015-C-203 | Human | Colorectum | FAP | 2.95e-42 | -7.52e-01 | -0.1294 |
| 60685 | ZFAND3 | A015-C-204 | Human | Colorectum | FAP | 3.28e-04 | -3.72e-01 | -0.0228 |
| 60685 | ZFAND3 | A014-C-040 | Human | Colorectum | FAP | 7.75e-09 | -7.81e-01 | -0.1184 |
| 60685 | ZFAND3 | A002-C-201 | Human | Colorectum | FAP | 2.27e-12 | -4.44e-01 | 0.0324 |
| 60685 | ZFAND3 | A001-C-119 | Human | Colorectum | FAP | 1.34e-12 | -7.03e-01 | -0.1557 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZFAND3 | SNV | Missense_Mutation | novel | c.184N>A | p.Glu62Lys | p.E62K | Q9H8U3 | protein_coding | tolerated(0.71) | benign(0.007) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZFAND3 | insertion | Nonsense_Mutation | novel | c.524_525insAATTGTGAAAGCATAGTGATACAGAGATACATTAGACATAGTCC | p.Cys176IlefsTer5 | p.C176Ifs*5 | Q9H8U3 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ZFAND3 | SNV | Missense_Mutation | novel | c.523C>A | p.Arg175Ser | p.R175S | Q9H8U3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ZFAND3 | SNV | Missense_Mutation | c.413A>T | p.Glu138Val | p.E138V | Q9H8U3 | protein_coding | deleterious(0.02) | benign(0.036) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ZFAND3 | deletion | Frame_Shift_Del | novel | c.358delA | p.Thr120GlnfsTer12 | p.T120Qfs*12 | Q9H8U3 | protein_coding | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ZFAND3 | SNV | Missense_Mutation | novel | c.667N>A | p.Gly223Arg | p.G223R | Q9H8U3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ZFAND3 | SNV | Missense_Mutation | novel | c.383N>A | p.Ala128Asp | p.A128D | Q9H8U3 | protein_coding | tolerated(0.1) | benign(0.08) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZFAND3 | SNV | Missense_Mutation | rs112599440 | c.554N>A | p.Arg185His | p.R185H | Q9H8U3 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZFAND3 | SNV | Missense_Mutation | novel | c.347G>T | p.Arg116Ile | p.R116I | Q9H8U3 | protein_coding | deleterious(0) | possibly_damaging(0.798) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| ZFAND3 | SNV | Missense_Mutation | rs765595688 | c.443G>A | p.Arg148Gln | p.R148Q | Q9H8U3 | protein_coding | tolerated(0.21) | benign(0.157) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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