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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9992

FusionGeneSummary for DIP2A_NRIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DIP2A_NRIP1
Fusion gene ID: 9992
HgeneTgene
Gene symbol

DIP2A

NRIP1

Gene ID

23181

8204

Gene namedisco interacting protein 2 homolog Anuclear receptor interacting protein 1
SynonymsC21orf106|DIP2RIP140
Cytomap

21q22.3

21q11.2-q21.1

Type of geneprotein-codingprotein-coding
Descriptiondisco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2Anuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140
Modification date2018052320180523
UniProtAcc

Q14689

P48552

Ensembl transtripts involved in fusion geneENST00000400274, ENST00000427143, 
ENST00000318711, ENST00000417564, 
ENST00000457905, ENST00000466639, 
ENST00000435722, ENST00000479654, 
ENST00000318948, ENST00000400199, 
ENST00000400202, 
Fusion gene scores* DoF score9 X 8 X 7=5042 X 1 X 2=4
# samples 82
** MAII scorelog2(8/504*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: DIP2A [Title/Abstract] AND NRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIP2A

GO:0010629

negative regulation of gene expression

20860622

TgeneNRIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

10364267

TgeneNRIP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7641693|10364267

TgeneNRIP1

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-D6-A4Z9-01ADIP2Achr21

47929289

+NRIP1chr21

16340847

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000400274ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000400274ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000400274ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000427143ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000427143ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000427143ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000318711ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000318711ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000318711ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000417564ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000417564ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000417564ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000457905ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000457905ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000457905ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000466639ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000466639ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000466639ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000435722ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000435722ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
5CDS-5UTRENST00000435722ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-
intron-5UTRENST00000479654ENST00000318948DIP2Achr21

47929289

+NRIP1chr21

16340847

-
intron-5UTRENST00000479654ENST00000400199DIP2Achr21

47929289

+NRIP1chr21

16340847

-
intron-5UTRENST00000479654ENST00000400202DIP2Achr21

47929289

+NRIP1chr21

16340847

-

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FusionProtFeatures for DIP2A_NRIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIP2A

Q14689

NRIP1

P48552

May provide positional cues for axon pathfinding andpatterning in the central nervous system. Modulates transcriptional activation by steroidreceptors such as NR3C1, NR3C2 and ESR1. Also modulatestranscriptional repression by nuclear hormone receptors. Positiveregulator of the circadian clock gene expression: stimulatestranscription of ARNTL/BMAL1, CLOCK and CRY1 by acting as acoactivator for RORA and RORC. {ECO:0000269|PubMed:10364267,ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808,ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175,ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIP2A_NRIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIP2A_NRIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DIP2AMRGBP, JMJD6, AES, PTPN3, TRIP13, TMCC2, SORBS3, PSME3, ZBTB43, MBIP, ADAMTSL4, GPATCH2L, TRIM39, CCDC33, FAM214B, CEP44, STAC3, NXF1, SPINT2, EFNB2, TEX264, TGFBR2, BTN2A1, DLK1, LPCAT1, PTGER3, THBS3, C1orf186, EGFR, HAVCR2, MANSC1, SELE, TPCN2, SSSCA1, IL20RANRIP1NR5A1, NR0B1, LDOC1, TEX11, CEP70, CTBP2, TRAF2, CCDC85B, CTBP1, HDAC5, RARA, NR3C1, YWHAQ, RXRA, ESR1, AHR, PPARA, PPARG, THRA, RXRB, JUN, PRMT1, HDAC3, CARM1, XPO1, KPNB1, ESRRA, ESRRB, ESRRG, ESR2, E2F1, ACTN2, CIB1, NR1H2, THRB, RORB, NR1H3, VDR, HNF4A, NR5A2, ELAVL1, CDK8, NR3C2, APP, FHL1, DNMT1, DNMT3A, DNMT3B, PPARGC1A, ARPC3, BRCA1, MAGEA10, HDAC1, HDAC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIP2A_NRIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIP2A_NRIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRIP1C0014170Endometrial Neoplasms1CTD_human
TgeneNRIP1C0018801Heart failure1CTD_human
TgeneNRIP1C0027051Myocardial Infarction1CTD_human
TgeneNRIP1C0036341Schizophrenia1CTD_human
TgeneNRIP1C1458155Mammary Neoplasms1CTD_human