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Fusion gene ID: 9986 |
FusionGeneSummary for DIMT1_RNF144B |
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Fusion gene information | Fusion gene name: DIMT1_RNF144B | Fusion gene ID: 9986 | Hgene | Tgene | Gene symbol | DIMT1 | RNF144B | Gene ID | 27292 | 255488 |
Gene name | DIM1 dimethyladenosine transferase 1 homolog | ring finger protein 144B | |
Synonyms | DIM1|DIMT1L|HSA9761|HUSSY5 | IBRDC2|PIR2|bA528A10.3|p53RFP | |
Cytomap | 5q12.1 | 6p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | probable dimethyladenosine transferase18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase18S rRNA dimethylaseDIM1 dimethyladenosine transferase 1-likeS-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferasedimethyladenosine tr | E3 ubiquitin-protein ligase RNF144BIBR domain containing 2IBR domain-containing protein 2p53-inducible RING finger protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UNQ2 | Q7Z419 | |
Ensembl transtripts involved in fusion gene | ENST00000199320, ENST00000506390, | ENST00000429054, ENST00000259939, ENST00000486622, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DIMT1 [Title/Abstract] AND RNF144B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RNF144B | GO:0006511 | ubiquitin-dependent protein catabolic process | 12853982 |
Tgene | RNF144B | GO:0043066 | negative regulation of apoptotic process | 20300062 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE837524 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000199320 | ENST00000429054 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
intron-intron | ENST00000199320 | ENST00000259939 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
intron-intron | ENST00000199320 | ENST00000486622 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
intron-intron | ENST00000506390 | ENST00000429054 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
intron-intron | ENST00000506390 | ENST00000259939 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
intron-intron | ENST00000506390 | ENST00000486622 | DIMT1 | chr5 | 61686310 | + | RNF144B | chr6 | 18389702 | - |
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FusionProtFeatures for DIMT1_RNF144B |
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Hgene | Tgene |
DIMT1 | RNF144B |
Specifically dimethylates two adjacent adenosines in theloop of a conserved hairpin near the 3'-end of 18S rRNA in the 40Sparticle (PubMed:25851604). Involved in the pre-rRNA processingsteps leading to small-subunit rRNA production independently ofits RNA-modifying catalytic activity (PubMed:25851604).{ECO:0000269|PubMed:25851604}. | E3 ubiquitin-protein ligase which accepts ubiquitin fromE2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form ofa thioester and then directly transfers the ubiquitin to targetedsubstrates such as LCMT2, thereby promoting their degradation.Induces apoptosis via a p53/TP53-dependent but caspase-independentmechanism. However, its overexpression also produces a decrease ofthe ubiquitin-dependent stability of BAX, a pro-apoptotic protein,ultimately leading to protection of cell death; But, it is not ananti-apoptotic protein per se. {ECO:0000269|PubMed:12853982,ECO:0000269|PubMed:20300062}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DIMT1_RNF144B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DIMT1_RNF144B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DIMT1_RNF144B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DIMT1_RNF144B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |