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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9986

FusionGeneSummary for DIMT1_RNF144B

check button Fusion gene summary
Fusion gene informationFusion gene name: DIMT1_RNF144B
Fusion gene ID: 9986
HgeneTgene
Gene symbol

DIMT1

RNF144B

Gene ID

27292

255488

Gene nameDIM1 dimethyladenosine transferase 1 homologring finger protein 144B
SynonymsDIM1|DIMT1L|HSA9761|HUSSY5IBRDC2|PIR2|bA528A10.3|p53RFP
Cytomap

5q12.1

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionprobable dimethyladenosine transferase18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase18S rRNA dimethylaseDIM1 dimethyladenosine transferase 1-likeS-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferasedimethyladenosine trE3 ubiquitin-protein ligase RNF144BIBR domain containing 2IBR domain-containing protein 2p53-inducible RING finger protein
Modification date2018052320180523
UniProtAcc

Q9UNQ2

Q7Z419

Ensembl transtripts involved in fusion geneENST00000199320, ENST00000506390, 
ENST00000429054, ENST00000259939, 
ENST00000486622, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIMT1 [Title/Abstract] AND RNF144B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF144B

GO:0006511

ubiquitin-dependent protein catabolic process

12853982

TgeneRNF144B

GO:0043066

negative regulation of apoptotic process

20300062


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE837524DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000199320ENST00000429054DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
intron-intronENST00000199320ENST00000259939DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
intron-intronENST00000199320ENST00000486622DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
intron-intronENST00000506390ENST00000429054DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
intron-intronENST00000506390ENST00000259939DIMT1chr5

61686310

+RNF144Bchr6

18389702

-
intron-intronENST00000506390ENST00000486622DIMT1chr5

61686310

+RNF144Bchr6

18389702

-

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FusionProtFeatures for DIMT1_RNF144B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIMT1

Q9UNQ2

RNF144B

Q7Z419

Specifically dimethylates two adjacent adenosines in theloop of a conserved hairpin near the 3'-end of 18S rRNA in the 40Sparticle (PubMed:25851604). Involved in the pre-rRNA processingsteps leading to small-subunit rRNA production independently ofits RNA-modifying catalytic activity (PubMed:25851604).{ECO:0000269|PubMed:25851604}. E3 ubiquitin-protein ligase which accepts ubiquitin fromE2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form ofa thioester and then directly transfers the ubiquitin to targetedsubstrates such as LCMT2, thereby promoting their degradation.Induces apoptosis via a p53/TP53-dependent but caspase-independentmechanism. However, its overexpression also produces a decrease ofthe ubiquitin-dependent stability of BAX, a pro-apoptotic protein,ultimately leading to protection of cell death; But, it is not ananti-apoptotic protein per se. {ECO:0000269|PubMed:12853982,ECO:0000269|PubMed:20300062}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIMT1_RNF144B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIMT1_RNF144B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIMT1_RNF144B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIMT1_RNF144B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource