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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9975

FusionGeneSummary for DICER1_NEK7

check button Fusion gene summary
Fusion gene informationFusion gene name: DICER1_NEK7
Fusion gene ID: 9975
HgeneTgene
Gene symbol

DICER1

NEK7

Gene ID

23405

140609

Gene namedicer 1, ribonuclease IIINIMA related kinase 7
SynonymsDCR1|Dicer|Dicer1e|HERNA|K12H4.8-LIKE|MNG1|RMSE2-
Cytomap

14q32.13

1q31.3

Type of geneprotein-codingprotein-coding
Descriptionendoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motifserine/threonine-protein kinase Nek7NIMA (never in mitosis gene a)-related kinase 7never in mitosis A-related kinase 7nimA-related protein kinase 7
Modification date2018052320180522
UniProtAcc

Q9UPY3

Q8TDX7

Ensembl transtripts involved in fusion geneENST00000343455, ENST00000526495, 
ENST00000393063, ENST00000527416, 
ENST00000527414, ENST00000556045, 
ENST00000541352, 		ENST00000367385, 
ENST00000538004, ENST00000367383, 
ENST00000417895, 
Fusion gene scores* DoF score8 X 5 X 6=2404 X 4 X 2=32
# samples 95
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DICER1 [Title/Abstract] AND NEK7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDICER1

GO:0030422

production of siRNA involved in RNA interference

15973356|17452327|23661684

HgeneDICER1

GO:0031054

pre-miRNA processing

15973356|16357216|18178619|23661684|25549615

HgeneDICER1

GO:0035087

siRNA loading onto RISC involved in RNA interference

15973356

HgeneDICER1

GO:0035196

production of miRNAs involved in gene silencing by miRNA

15973356|23661684

HgeneDICER1

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619

HgeneDICER1

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

21753850|25549615

TgeneNEK7

GO:0006468

protein phosphorylation

12840024


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA248769DICER1chr14

95556396

+NEK7chr1

198240917

-
ChiTaRS3.1AA248863DICER1chr14

95556396

+NEK7chr1

198240917

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000343455ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000343455ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000343455ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000343455ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000526495ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000526495ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000526495ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000526495ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000393063ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000393063ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000393063ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000393063ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527416ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527416ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527416ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527416ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527414ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527414ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527414ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000527414ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000556045ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000556045ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000556045ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000556045ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000541352ENST00000367385DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000541352ENST00000538004DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000541352ENST00000367383DICER1chr14

95556396

+NEK7chr1

198240917

-
intron-intronENST00000541352ENST00000417895DICER1chr14

95556396

+NEK7chr1

198240917

-

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FusionProtFeatures for DICER1_NEK7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DICER1

Q9UPY3

NEK7

Q8TDX7

Double-stranded RNA (dsRNA) endoribonuclease playing acentral role in short dsRNA-mediated post-transcriptional genesilencing. Cleaves naturally occurring long dsRNAs and shorthairpin pre-microRNAs (miRNA) into fragments of twenty-one totwenty-three nucleotides with 3' overhang of two nucleotides,producing respectively short interfering RNAs (siRNA) and maturemicroRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degradethem or prevent their translation. Gene silencing mediated bysiRNAs, also called RNA interference, controls the elimination oftranscripts from mobile and repetitive DNA elements of the genomebut also the degradation of exogenous RNA of viral origin forinstance. The miRNA pathway on the other side is a mean tospecifically regulate the expression of target genes.{ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356,ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387,ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216,ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327,ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}. Protein kinase which plays an important role in mitoticcell cycle progression. Required for microtubule nucleationactivity of the centrosome, robust mitotic spindle formation andcytokinesis. Phosphorylates RPS6KB1. {ECO:0000269|PubMed:17101132,ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DICER1_NEK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DICER1_NEK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DICER1_NEK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DICER1_NEK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDICER1C0036341Schizophrenia2PSYGENET
HgeneDICER1C0014175Endometriosis1CTD_human
HgeneDICER1C0028960Oligospermia1CTD_human
HgeneDICER1C0302859Euthyroid Goiter1ORPHANET;UNIPROT
HgeneDICER1C1266144Pleuropulmonary blastoma1CTD_human;HPO;ORPHANET;UNIPROT
TgeneNEK7C0043094Weight Gain1CTD_human