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Fusion gene ID: 9974 |
FusionGeneSummary for DICER1_HSD17B4 |
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Fusion gene information | Fusion gene name: DICER1_HSD17B4 | Fusion gene ID: 9974 | Hgene | Tgene | Gene symbol | DICER1 | HSD17B4 | Gene ID | 23405 | 3295 |
Gene name | dicer 1, ribonuclease III | hydroxysteroid 17-beta dehydrogenase 4 | |
Synonyms | DCR1|Dicer|Dicer1e|HERNA|K12H4.8-LIKE|MNG1|RMSE2 | DBP|MFE-2|MPF-2|PRLTS1|SDR8C1 | |
Cytomap | 14q32.13 | 5q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | endoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motif | peroxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratase | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9UPY3 | P51659 | |
Ensembl transtripts involved in fusion gene | ENST00000343455, ENST00000526495, ENST00000393063, ENST00000527416, ENST00000527414, ENST00000556045, ENST00000541352, | ENST00000256216, ENST00000515320, ENST00000510025, ENST00000504811, ENST00000414835, ENST00000513628, ENST00000509514, ENST00000522415, | |
Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 4 X 2 X 3=24 |
# samples | 9 | 4 | |
** MAII score | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DICER1 [Title/Abstract] AND HSD17B4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DICER1 | GO:0030422 | production of siRNA involved in RNA interference | 15973356|17452327|23661684 |
Hgene | DICER1 | GO:0031054 | pre-miRNA processing | 15973356|16357216|18178619|23661684|25549615 |
Hgene | DICER1 | GO:0035087 | siRNA loading onto RISC involved in RNA interference | 15973356 |
Hgene | DICER1 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA | 15973356|23661684 |
Hgene | DICER1 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 18178619 |
Hgene | DICER1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 21753850|25549615 |
Tgene | HSD17B4 | GO:0006635 | fatty acid beta-oxidation | 10400999 |
Tgene | HSD17B4 | GO:0008209 | androgen metabolic process | 7487879 |
Tgene | HSD17B4 | GO:0008210 | estrogen metabolic process | 7487879 |
Tgene | HSD17B4 | GO:0036111 | very long-chain fatty-acyl-CoA metabolic process | 9482850 |
Tgene | HSD17B4 | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process | 9089413 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-SL-A6JA-01A | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000343455 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3CDS | ENST00000343455 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
5UTR-3UTR | ENST00000343455 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000526495 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000526495 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000393063 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000393063 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527416 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000527416 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000527414 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000527414 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000556045 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000556045 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000256216 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000515320 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000510025 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000504811 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000414835 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000513628 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3CDS | ENST00000541352 | ENST00000509514 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
intron-3UTR | ENST00000541352 | ENST00000522415 | DICER1 | chr14 | 95623567 | - | HSD17B4 | chr5 | 118872118 | + |
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FusionProtFeatures for DICER1_HSD17B4 |
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Hgene | Tgene |
DICER1 | HSD17B4 |
Double-stranded RNA (dsRNA) endoribonuclease playing acentral role in short dsRNA-mediated post-transcriptional genesilencing. Cleaves naturally occurring long dsRNAs and shorthairpin pre-microRNAs (miRNA) into fragments of twenty-one totwenty-three nucleotides with 3' overhang of two nucleotides,producing respectively short interfering RNAs (siRNA) and maturemicroRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degradethem or prevent their translation. Gene silencing mediated bysiRNAs, also called RNA interference, controls the elimination oftranscripts from mobile and repetitive DNA elements of the genomebut also the degradation of exogenous RNA of viral origin forinstance. The miRNA pathway on the other side is a mean tospecifically regulate the expression of target genes.{ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356,ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387,ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216,ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327,ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}. | Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. {ECO:0000269|PubMed:8902629,ECO:0000269|PubMed:9089413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DICER1_HSD17B4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DICER1_HSD17B4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DICER1 | AGO1, AGO3, AGO4, PIWIL4, PIWIL3, PIWIL2, AGO2, USP49, DHX58, EIF2AK2, PIWIL1, SIRT7, DHX9, CUL3, ALB, NOS2, GEMIN4, CALCOCO2, TARBP2, MMS19, NPM1, HDAC11, DDX20, SMN1, DICER1, PRKAB2, ALOX5, CUL4A, FBXL14, TRIM71, MTFR2, GNL2, GTPBP4, MTFR1, MYSM1, NOC3L, POP1, PRKRA, STAU2, AURKA, CCDC8, ZMAT3, RPS2, MEMO1, PNKD, SFRP4, ILF2, AAMP, FOXD4L6, PRG2, USP7, KALRN, NTRK1, CEP19, HNRNPD, RAP1B, SORT1, MAD2L2, SYNCRIP, TIMM13, SGTB, ACTR5, USF1, CRY2, TRMT2A, ADAMTS4, CPA6, TRIM41, STRBP, KIAA1683, RPL15, CFAP20, INO80B, TRIM25 | HSD17B4 | UBA5, UBC, NDRG1, MYC, GRB2, SNCA, ACAA1, SCP2, CAT, GRHPR, SSBP1, FIS1, GNB2L1, VAMP2, PEX5, PEX14, ADRB2, CASP9, BAK1, CDK7, MAPK8, HECW2, STAU1, CUL7, CCDC8, DECR1, EEF2, IDH1, NTRK1, SCARNA22, RPGRIP1, FOS, HNRNPD, HNRNPU, SORT1, RACGAP1, NF2, CDC73, PPM1A, DUSP22, DUSP4, IKZF1, DLD, DLST, PDHA1, SDHA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DICER1_HSD17B4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DICER1_HSD17B4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DICER1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | DICER1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | DICER1 | C0028960 | Oligospermia | 1 | CTD_human |
Hgene | DICER1 | C0302859 | Euthyroid Goiter | 1 | ORPHANET;UNIPROT |
Hgene | DICER1 | C1266144 | Pleuropulmonary blastoma | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
Tgene | HSD17B4 | C0342870 | Bifunctional peroxisomal enzyme deficiency | 4 | CTD_human;ORPHANET;UNIPROT |
Tgene | HSD17B4 | C0282528 | Peroxisomal Disorders | 2 | CTD_human |
Tgene | HSD17B4 | C0685838 | Gonadal dysgenesis XX type deafness | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | HSD17B4 | C0037769 | West Syndrome | 1 | CTD_human |
Tgene | HSD17B4 | C0043459 | Zellweger Syndrome | 1 | CTD_human |