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Fusion gene ID: 997 |
FusionGeneSummary for AFF1_ARHGAP17 |
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Fusion gene information | Fusion gene name: AFF1_ARHGAP17 | Fusion gene ID: 997 | Hgene | Tgene | Gene symbol | AFF1 | ARHGAP17 | Gene ID | 4299 | 55114 |
Gene name | AF4/FMR2 family member 1 | Rho GTPase activating protein 17 | |
Synonyms | AF4|MLLT2|PBM1 | MST066|MST110|MSTP038|MSTP066|MSTP110|NADRIN|PP367|PP4534|RICH-1|RICH1|WBP15 | |
Cytomap | 4q21.3-q22.1 | 16p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | rho GTPase-activating protein 17RhoGAP interacting with CIP4 homologs 1neuron-associated developmentally regulated proteinrho-type GTPase-activating protein 17 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P51825 | Q68EM7 | |
Ensembl transtripts involved in fusion gene | ENST00000395146, ENST00000307808, ENST00000544085, ENST00000511996, | ENST00000289968, ENST00000441763, ENST00000303665, ENST00000575975, | |
Fusion gene scores | * DoF score | 16 X 29 X 8=3712 | 3 X 3 X 1=9 |
# samples | 40 | 3 | |
** MAII score | log2(40/3712*10)=-3.21412480535285 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AFF1 [Title/Abstract] AND ARHGAP17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI030606 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000395146 | ENST00000289968 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000395146 | ENST00000441763 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000395146 | ENST00000303665 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-intron | ENST00000395146 | ENST00000575975 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3CDS | ENST00000307808 | ENST00000289968 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000307808 | ENST00000441763 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000307808 | ENST00000303665 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-intron | ENST00000307808 | ENST00000575975 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3CDS | ENST00000544085 | ENST00000289968 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000544085 | ENST00000441763 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000544085 | ENST00000303665 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-intron | ENST00000544085 | ENST00000575975 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3CDS | ENST00000511996 | ENST00000289968 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000511996 | ENST00000441763 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-3UTR | ENST00000511996 | ENST00000303665 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
intron-intron | ENST00000511996 | ENST00000575975 | AFF1 | chr4 | 87928684 | + | ARHGAP17 | chr16 | 24942612 | + |
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FusionProtFeatures for AFF1_ARHGAP17 |
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Hgene | Tgene |
AFF1 | ARHGAP17 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AFF1_ARHGAP17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AFF1_ARHGAP17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AFF1_ARHGAP17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AFF1_ARHGAP17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |