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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9965

FusionGeneSummary for DIAPH2_NRP2

check button Fusion gene summary
Fusion gene informationFusion gene name: DIAPH2_NRP2
Fusion gene ID: 9965
HgeneTgene
Gene symbol

DIAPH2

NRP2

Gene ID

1730

8828

Gene namediaphanous related formin 2neuropilin 2
SynonymsDIA|DIA2|DRF2|POF|POF2|POF2ANP2|NPN2|PRO2714|VEGF165R2
Cytomap

Xq21.33

2q33.3

Type of geneprotein-codingprotein-coding
Descriptionprotein diaphanous homolog 2diaphanous homolog 2diaphorase-2neuropilin-2neuropilin-2a(17)neuropilin-2a(22)neuropilin-2b(0)receptor for VEGF165 and semaphorins class3vascular endothelial cell growth factor 165 receptor 2
Modification date2018051920180519
UniProtAcc

O60879

O60462

Ensembl transtripts involved in fusion geneENST00000355827, ENST00000373054, 
ENST00000373061, ENST00000373049, 
ENST00000324765, 		ENST00000355117, 
ENST00000540841, ENST00000540178, 
ENST00000360409, ENST00000417189, 
ENST00000357118, ENST00000357785, 
ENST00000272849, ENST00000412873, 
ENST00000485684, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 3 X 4=48
# samples 84
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIAPH2 [Title/Abstract] AND NRP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-XR-A8TG-01ADIAPH2chrX

95940189

+NRP2chr2

206656959

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355827ENST00000355117DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000540841DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000540178DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000360409DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000417189DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000357118DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000357785DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000272849DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000412873DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000355827ENST00000485684DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000355117DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000540841DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000540178DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000360409DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000417189DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000357118DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000357785DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000272849DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000412873DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373054ENST00000485684DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000355117DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000540841DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000540178DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000360409DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000417189DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000357118DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000357785DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000272849DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000412873DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373061ENST00000485684DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000355117DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000540841DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000540178DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000360409DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000417189DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000357118DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000357785DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000272849DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000412873DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000373049ENST00000485684DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000355117DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000540841DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000540178DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000360409DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000417189DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000357118DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000357785DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000272849DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000412873DIAPH2chrX

95940189

+NRP2chr2

206656959

+
5CDS-intronENST00000324765ENST00000485684DIAPH2chrX

95940189

+NRP2chr2

206656959

+

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FusionProtFeatures for DIAPH2_NRP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIAPH2

O60879

NRP2

O60462

Could be involved in oogenesis. Involved in theregulation of endosome dynamics. Implicated in a novel signaltransduction pathway, in which isoform 3 and CSK are sequentiallyactivated by RHOD to regulate the motility of early endosomesthrough interactions with the actin cytoskeleton.{ECO:0000269|PubMed:12577064}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIAPH2_NRP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIAPH2_NRP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DIAPH2RHOD, CDC42, TCERG1, APBB1, POLR1A, PAPD5NRP2RYK, TGFBR2, FCGR3B, TAZ, NXPH2, ATP1B3, SIAE, NAAA, ST8SIA3, DEFA5, BRINP3, ST8SIA4, TSPAN11, LYZL1, PCDHGB1, DEFA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIAPH2_NRP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIAPH2_NRP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRP2C0004352Autistic Disorder1CTD_human
TgeneNRP2C0036572Seizures1CTD_human