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Fusion gene ID: 994 |
FusionGeneSummary for AFAP1_SLC45A1 |
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Fusion gene information | Fusion gene name: AFAP1_SLC45A1 | Fusion gene ID: 994 | Hgene | Tgene | Gene symbol | AFAP1 | SLC45A1 | Gene ID | 60312 | 50651 |
Gene name | actin filament associated protein 1 | solute carrier family 45 member 1 | |
Synonyms | AFAP|AFAP-110|AFAP110 | DNB5|IDDNPF | |
Cytomap | 4p16.1 | 1p36.23 | |
Type of gene | protein-coding | protein-coding | |
Description | actin filament-associated protein 1110 kDa actin filament-associated proteinactin filament-associated protein, 110 kDa | proton-associated sugar transporter AH+/sugar symporterPAST-Adeleted in neuroblastoma 5 protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8N556 | Q9Y2W3 | |
Ensembl transtripts involved in fusion gene | ENST00000360265, ENST00000358461, ENST00000420658, ENST00000382543, ENST00000513842, | ENST00000471889, ENST00000377479, ENST00000289877, ENST00000481265, | |
Fusion gene scores | * DoF score | 8 X 10 X 6=480 | 3 X 2 X 3=18 |
# samples | 12 | 3 | |
** MAII score | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AFAP1 [Title/Abstract] AND SLC45A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-46-3769-01A | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000360265 | ENST00000471889 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000360265 | ENST00000377479 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000360265 | ENST00000289877 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000360265 | ENST00000481265 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000358461 | ENST00000471889 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000358461 | ENST00000377479 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000358461 | ENST00000289877 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000358461 | ENST00000481265 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000420658 | ENST00000471889 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000420658 | ENST00000377479 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000420658 | ENST00000289877 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000420658 | ENST00000481265 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000382543 | ENST00000471889 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-5UTR | ENST00000382543 | ENST00000377479 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000382543 | ENST00000289877 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
5CDS-intron | ENST00000382543 | ENST00000481265 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
intron-5UTR | ENST00000513842 | ENST00000471889 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
intron-5UTR | ENST00000513842 | ENST00000377479 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
intron-intron | ENST00000513842 | ENST00000289877 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
intron-intron | ENST00000513842 | ENST00000481265 | AFAP1 | chr4 | 7802169 | - | SLC45A1 | chr1 | 8384366 | + |
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FusionProtFeatures for AFAP1_SLC45A1 |
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Hgene | Tgene |
AFAP1 | SLC45A1 |
Can cross-link actin filaments into both network andbundle structures (By similarity). May modulate changes in actinfilament integrity and induce lamellipodia formation. May functionas an adapter molecule that links other proteins, such as SRC andPKC to the actin cytoskeleton. Seems to play a role in thedevelopment and progression of prostate adenocarcinoma byregulating cell-matrix adhesions and migration in the cancercells. {ECO:0000250, ECO:0000269|PubMed:15485829}. | Proton-associated glucose transporter in the brain.{ECO:0000250|UniProtKB:Q8K4S3, ECO:0000269|PubMed:28434495}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AFAP1_SLC45A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AFAP1_SLC45A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AFAP1 | AFAP1, ACTC1, PRKCB, PRKCE, PRKCG, PRKCD, PRKCA, MYC, NXF1, BRCA1, CAPZA2, CDK2, DBN1, FLNA, GAK, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, TPX2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, EXT2, TRIM25, TES | SLC45A1 | PPP1CA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AFAP1_SLC45A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AFAP1_SLC45A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |