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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9935

FusionGeneSummary for DHX57_MCF2

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX57_MCF2
Fusion gene ID: 9935
HgeneTgene
Gene symbol

DHX57

MCF2

Gene ID

90957

4168

Gene nameDExH-box helicase 57MCF.2 cell line derived transforming sequence
SynonymsDDX57ARHGEF21|DBL
Cytomap

2p22.1

Xq27.1

Type of geneprotein-codingprotein-coding
Descriptionputative ATP-dependent RNA helicase DHX57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57DEAH box protein 57DEAH-box RNA/DNA helicase AAM73547DEAH-box helicase 57proto-oncogene DBLOncogene MCF2 (oncogene DBL)proto-oncogene MCF-2
Modification date2018052320180522
UniProtAcc

Q6P158

P10911

Ensembl transtripts involved in fusion geneENST00000295373, ENST00000479345, 
ENST00000520602, ENST00000370576, 
ENST00000536274, ENST00000370578, 
ENST00000414978, ENST00000519895, 
ENST00000370573, ENST00000338585, 
ENST00000483690, 
Fusion gene scores* DoF score4 X 4 X 2=323 X 3 X 1=9
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHX57 [Title/Abstract] AND MCF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA274457DHX57chr2

39070933

+MCF2chrX

138687939

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000295373ENST00000520602DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000370576DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000536274DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000370578DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000414978DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000519895DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000370573DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000295373ENST00000338585DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-intronENST00000295373ENST00000483690DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000520602DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000370576DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000536274DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000370578DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000414978DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000519895DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000370573DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-3CDSENST00000479345ENST00000338585DHX57chr2

39070933

+MCF2chrX

138687939

-
intron-intronENST00000479345ENST00000483690DHX57chr2

39070933

+MCF2chrX

138687939

-

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FusionProtFeatures for DHX57_MCF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX57

Q6P158

MCF2

P10911

Probable ATP-binding RNA helicase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DHX57_MCF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DHX57_MCF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHX57_MCF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DHX57_MCF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource