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Fusion gene ID: 9900 |
FusionGeneSummary for DHX15_CCND3 |
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Fusion gene information | Fusion gene name: DHX15_CCND3 | Fusion gene ID: 9900 | Hgene | Tgene | Gene symbol | DHX15 | CCND3 | Gene ID | 1665 | 896 |
Gene name | DEAH-box helicase 15 | cyclin D3 | |
Synonyms | DBP1|DDX15|HRH2|PRP43|PRPF43|PrPp43p | - | |
Cytomap | 4p15.2 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15ATP-dependent RNA helicase #46DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15DEAD/H box-15DEAH (Asp-Glu-Ala-His) box helicase 15DEAH (Asp-Glu-Ala-His) box polypeptide 15DEAH box protein 15RNA | G1/S-specific cyclin-D3D3-type cyclin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43143 | P30281 | |
Ensembl transtripts involved in fusion gene | ENST00000508032, ENST00000336812, | ENST00000511642, ENST00000415497, ENST00000372988, ENST00000510503, ENST00000511686, ENST00000372991, ENST00000372987, ENST00000414200, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 6 X 2 X 5=60 |
# samples | 4 | 6 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: DHX15 [Title/Abstract] AND CCND3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CCND3 | GO:0001934 | positive regulation of protein phosphorylation | 8114739 |
Tgene | CCND3 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 8114739 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A3LU-01A | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000508032 | ENST00000511642 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-intron | ENST00000508032 | ENST00000415497 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-5UTR | ENST00000508032 | ENST00000372988 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-5UTR | ENST00000508032 | ENST00000510503 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-intron | ENST00000508032 | ENST00000511686 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-intron | ENST00000508032 | ENST00000372991 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-intron | ENST00000508032 | ENST00000372987 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
intron-intron | ENST00000508032 | ENST00000414200 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-5UTR | ENST00000336812 | ENST00000511642 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-intron | ENST00000336812 | ENST00000415497 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-5UTR | ENST00000336812 | ENST00000372988 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-5UTR | ENST00000336812 | ENST00000510503 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-intron | ENST00000336812 | ENST00000511686 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-intron | ENST00000336812 | ENST00000372991 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-intron | ENST00000336812 | ENST00000372987 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
5CDS-intron | ENST00000336812 | ENST00000414200 | DHX15 | chr4 | 24543496 | - | CCND3 | chr6 | 41908323 | - |
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FusionProtFeatures for DHX15_CCND3 |
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Hgene | Tgene |
DHX15 | CCND3 |
Pre-mRNA processing factor involved in disassembly ofspliceosomes after the release of mature mRNA. In cooperation withTFIP11 seem to be involved in the transition of the U2, U5 and U6snRNP-containing IL complex to the snRNP-free IS complex leadingto efficient debranching and turnover of excised introns.{ECO:0000269|PubMed:19103666}. | Regulatory component of the cyclin D3-CDK4 (DC) complexthat phosphorylates and inhibits members of the retinoblastoma(RB) protein family including RB1 and regulates the cell-cycleduring G(1)/S transition. Phosphorylation of RB1 allowsdissociation of the transcription factor E2F from the RB/E2Fcomplex and the subsequent transcription of E2F target genes whichare responsible for the progression through the G(1) phase.Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4complexes are major integrators of various mitogenenic andantimitogenic signals. Also substrate for SMAD3, phosphorylatingSMAD3 in a cell-cycle-dependent manner and repressing itstranscriptional activity. Component of the ternary complex, cyclinD3/CDK4/CDKN1B, required for nuclear translocation and activity ofthe cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHX15_CCND3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHX15_CCND3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DHX15 | RNU11, SF3A2, TAF10, TOPORS, TADA2A, MYC, HDAC5, YWHAB, YWHAG, PINX1, HDGF, ARRB2, SIRT7, HNRNPA1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, GRK5, SF3B6, SNRPD2, SF3A1, SRSF1, DDX5, PABPC1, SRSF5, HNRNPF, SYNCRIP, SRSF3, CDC5L, SNW1, ACIN1, SRSF7, SRRM2, DEK, HNRNPK, RBMX, NOP58, RPL31, NOP56, SUPT16H, FBL, VTN, ECSIT, GTF3C1, NDUFAF4, PFN2, TMEM126B, S100A9, SENP3, EIF2D, MMGT1, RPL36, SLC30A9, PCDHA2, RANBP2, SRSF10, LBR, EBNA1BP2, PEX3, NXF1, FUT8, IWS1, RPL22, ESR1, NOTCH1, EIF4A3, MAGOH, UBC, POLR2C, FN1, VCAM1, RBM17, RBM10, RBM5, SUGP1, DDX42, TRA2A, NKAP, ITGA4, CD81, IGSF8, NPM1, SRPK2, SRPK3, FBXO6, PRPF40A, WBP4, APBB1, PIN1, AHCY, FH, MSN, NSFL1C, PCNA, PPP1CB, MCTS1, PAPSS1, TMOD3, RPA1, RPA2, RPA3, WWOX, NUDCD1, STAU1, CEP250, CEP57, FUS, ZGPAT, ENO1, MOV10, CUL7, OBSL1, EED, EPB41L3, UNK, NTRK1, ATXN2, DDX17, DDX43, DDX18, DHX37, GGA1, HNRNPL, ILK, KHDRBS1, KIAA0020, NDRG1, PUS7, SRRM1, TXLNA, UFD1L, XAB2, DKC1, DNAJC9, HNRNPR, KIAA1143, MSH2, NEMF, NOC2L, NOL6, NOLC1, PABPC4, PES1, PRPF19, PRPF4, PRPF8, RBM15, RBM15B, RPF2, RPL12, RSU1, SEC31A, SF3A3, SF3B1, SF3B3, SKIV2L2, SNRNP200, SNRPA1, SRSF11, TDRD3, TRMT112, TTC27, USP3, WDR36, ZYX, RNU12, SFN, KIFAP3, CRY2, ALKBH3, MCM5, MCM2, NF2, USP37, U2AF2, ZNF746, KNOP1, NCL, CYLD, CD2BP2, INO80B, UBE2A, BRCA1, LMNA, RNF168, MTF1 | CCND3 | EIF3K, DTNBP1, EFEMP2, MAF1, CDKN1B, CDKN1A, CDK4, MCM10, AKAP8, RB1, ATP5C1, CDK6, RBX1, TSC2, NPDC1, PCNA, CDK11B, CRABP2, RARA, CASP2, NCOA2, CDK2, PPP1CA, PPP1CB, PPP1CC, APP, RBL2, POLD1, CDK14, SIL1, FAS, MYB, ETV1, GC, NME1, MAPK6, VDR, ATF5, CDK5, TFIP11, POLR3GL, CDK1, ZNF2, CLU, CDKN1C, CDKN2C, KLK5, CREBBP, AREG, STAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHX15_CCND3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX15_CCND3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DHX15 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |