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Fusion gene ID: 9899 |
FusionGeneSummary for DHX15_CCDC149 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX15_CCDC149 | Fusion gene ID: 9899 | Hgene | Tgene | Gene symbol | DHX15 | CCDC149 | Gene ID | 1665 | 91050 |
| Gene name | DEAH-box helicase 15 | coiled-coil domain containing 149 | |
| Synonyms | DBP1|DDX15|HRH2|PRP43|PRPF43|PrPp43p | - | |
| Cytomap | 4p15.2 | 4p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15ATP-dependent RNA helicase #46DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15DEAD/H box-15DEAH (Asp-Glu-Ala-His) box helicase 15DEAH (Asp-Glu-Ala-His) box polypeptide 15DEAH box protein 15RNA | coiled-coil domain-containing protein 149 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43143 | Q6ZUS6 | |
| Ensembl transtripts involved in fusion gene | ENST00000508032, ENST00000336812, | ENST00000504487, ENST00000428116, ENST00000389609, ENST00000502801, ENST00000508236, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 5 X 5 X 4=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHX15 [Title/Abstract] AND CCDC149 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4449-01A | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000508032 | ENST00000504487 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000428116 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000389609 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000502801 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| intron-intron | ENST00000508032 | ENST00000508236 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| In-frame | ENST00000336812 | ENST00000504487 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000428116 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000389609 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000502801 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
| 5CDS-intron | ENST00000336812 | ENST00000508236 | DHX15 | chr4 | 24550478 | - | CCDC149 | chr4 | 24839894 | - |
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FusionProtFeatures for DHX15_CCDC149 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHX15 | CCDC149 |
| Pre-mRNA processing factor involved in disassembly ofspliceosomes after the release of mature mRNA. In cooperation withTFIP11 seem to be involved in the transition of the U2, U5 and U6snRNP-containing IL complex to the snRNP-free IS complex leadingto efficient debranching and turnover of excised introns.{ECO:0000269|PubMed:19103666}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHX15_CCDC149 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DHX15_ENST00000336812_chr4_24550478_-_CCDC149_ENST00000504487_chr4_24839894_-_822aa MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAH STHSTHSAHSTHAGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRS LPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATD ILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQE EIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLE RAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNAL ERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTL EVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCK LFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGPAPPGLAIQGELPKSHLDSFEASRPAAKASTPEDGKGIP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DHX15_ENST00000336812_chr4_24550478_-_CCDC149_ENST00000504487_chr4_24839894_-_2466nt ATGTCCAAGCGGCACCGGTTGGACCTAGGGGAGGATTACCCCTCTGGCAAGAAGCGTGCGGGGACCGATGGGAAGGATCGAGATCGAGAC CGGGATCGTGAAGATCGGTCTAAAGATCGAGACCGAGAACGTGATAGAGGAGATAGAGAGCGAGAGAGGGAGAAAGAAAAGGAGAAGGAG TTGCGAGCTTCAACAAATGCTATGCTTATCAGTGCTGGATTACCACCTTTGAAAGCTTCCCATTCAGCTCACTCAACCCACTCAGCACAT TCAACGCATTCAACACATTCTGCTCATTCAACGCATGCCGGACATGCAGGTCACACGTCACTTCCACAGTGCATTAATCCGTTCACCAAC TTACCCCATACTCCTCGATACTATGATATTCTAAAGAAACGTCTTCAGCTCCCTGTTTGGGAATACAAGGATAGGTTTACAGATATTCTG GTTAGACATCAGTCCTTTGTACTGGTTGGTGAGACTGGGTCTGGTAAAACAACACAGATTCCACAGTGGTGTGTGGAGTACATGCGATCA TTACCAGGACCCAAGAGAGGAGTTGCCTGTACCCAACCCAGGAGAGTGGCTGCAATGAGTGTGGCTCAGAGAGTTGCTGATGAGATGGAT GTGATGTTGGGCCAGGAAGTTGGTTACTCCATTCGATTTGAAGACTGCAGTAGTGCAAAAACCATTCTTAAGTATATGACTGATGGGATG TTACTTCGTGAAGCTATGAATGATCCCCTCCTGGAGCGTTATGGTGTAATAATTCTTGATGAGGCTCATGAGAGGACACTGGCTACAGAT ATTCTAATGGGTGTTCTGAAGGAAGTTGTAAGACAGAGATCAGATTTAAAGGTTATAGTTATGAGCGCTACTCTAGATGCAGGAAAATTC CAGATTTACTTTGATAACTGTCCTCTCCTAACTATTCCTGGGCGTACACATCCTGTTGAGATCTTCTATACTCCAGAACCAGAGAGAGAT TATCTTGAAGCAGCAATTCGAACAGTTATCCAGATTCATATGTGTGAAGAGGAAGAGGGAGATCTTCTTCTTTTCTTAACTGGTCAAGAG GAAATTGATGAAGCCTGTAAGAGAATAAAGCGTGAAGTTGATGATTTGGGCCCTGAAGTTGGTGACATTAAAATCATTCCATTGTATTCT ACACTTCCACCTCAGCAGCAGCAACGCATTTTTGAGCCTCCACCTCCCAAAAAACAGAATGGAGCAATTGGAAGAAAGCTCTTGAGGATG ACGATTGCCAAACAAAGGCTCGGAGACGAAGCAATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAG CGAGCTAAGGAACAGATTGAGTCTCTGGAGCACGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTAC CAGGACAAAGTGGAGAGGCTCAACCAGGAGCTGAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATG GAGAACAGGTACCTTCAAGAGAGATTAAAGCAACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTG GAGAGACGGAAAAACTCGAAGGGCCAGGGTAAATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTA TCTGAGGATCATGGATGCAGCCTCCCAGCTACTCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCAC GAGAAAAACATGGTCATTCAGCACCAGAGGCAAACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTG GAAGTTTCTGGTTTGTGGAGTCTTCCAGGGGGCAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCC CCACTGCTGAAGTTTGTCGAGCAGCCCACTGAGAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGT GCCGCTGCTGAGGCGTTGACAGCGCCTGAGGATGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAG CTCTTTCATCCTTCATTACCCCAGTTACCTTCTGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCA GCTGCAGAACTGGAAGAGGTCAGAAGAGAGAGTCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAG GGGGAGCTCCCTAAATCTCACCTGGACTCCTTCGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DHX15_ENST00000336812_chr4_24550478_-_CCDC149_ENST00000504487_chr4_24839894_-_4895nt TCGCCGCCGCCATTTTAGCTGTTGGTTCCGGCCGCACCGTGTGGGCTGTAGTAGCGGGAGGGGTGGGGGTCCTCCAGAGTTAAGTGGCTG TCCTCGACTGTGCCCATACAGCAGCCAGCTTTCTTCCTTAATAACTGCCCGTTCGAAGAGTGCGAGGATGTCCAAGCGGCACCGGTTGGA CCTAGGGGAGGATTACCCCTCTGGCAAGAAGCGTGCGGGGACCGATGGGAAGGATCGAGATCGAGACCGGGATCGTGAAGATCGGTCTAA AGATCGAGACCGAGAACGTGATAGAGGAGATAGAGAGCGAGAGAGGGAGAAAGAAAAGGAGAAGGAGTTGCGAGCTTCAACAAATGCTAT GCTTATCAGTGCTGGATTACCACCTTTGAAAGCTTCCCATTCAGCTCACTCAACCCACTCAGCACATTCAACGCATTCAACACATTCTGC TCATTCAACGCATGCCGGACATGCAGGTCACACGTCACTTCCACAGTGCATTAATCCGTTCACCAACTTACCCCATACTCCTCGATACTA TGATATTCTAAAGAAACGTCTTCAGCTCCCTGTTTGGGAATACAAGGATAGGTTTACAGATATTCTGGTTAGACATCAGTCCTTTGTACT GGTTGGTGAGACTGGGTCTGGTAAAACAACACAGATTCCACAGTGGTGTGTGGAGTACATGCGATCATTACCAGGACCCAAGAGAGGAGT TGCCTGTACCCAACCCAGGAGAGTGGCTGCAATGAGTGTGGCTCAGAGAGTTGCTGATGAGATGGATGTGATGTTGGGCCAGGAAGTTGG TTACTCCATTCGATTTGAAGACTGCAGTAGTGCAAAAACCATTCTTAAGTATATGACTGATGGGATGTTACTTCGTGAAGCTATGAATGA TCCCCTCCTGGAGCGTTATGGTGTAATAATTCTTGATGAGGCTCATGAGAGGACACTGGCTACAGATATTCTAATGGGTGTTCTGAAGGA AGTTGTAAGACAGAGATCAGATTTAAAGGTTATAGTTATGAGCGCTACTCTAGATGCAGGAAAATTCCAGATTTACTTTGATAACTGTCC TCTCCTAACTATTCCTGGGCGTACACATCCTGTTGAGATCTTCTATACTCCAGAACCAGAGAGAGATTATCTTGAAGCAGCAATTCGAAC AGTTATCCAGATTCATATGTGTGAAGAGGAAGAGGGAGATCTTCTTCTTTTCTTAACTGGTCAAGAGGAAATTGATGAAGCCTGTAAGAG AATAAAGCGTGAAGTTGATGATTTGGGCCCTGAAGTTGGTGACATTAAAATCATTCCATTGTATTCTACACTTCCACCTCAGCAGCAGCA ACGCATTTTTGAGCCTCCACCTCCCAAAAAACAGAATGGAGCAATTGGAAGAAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCTCGG AGACGAAGCAATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGAGTC TCTGGAGCACGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCTCAA CCAGGAGCTGAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGAGAG ATTAAAGCAACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAAGGG CCAGGGTAAATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTATCTGAGGATCATGGATGCAGCCT CCCAGCTACTCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCACGAGAAAAACATGGTCATTCAGCA CCAGAGGCAAACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAGTCT TCCAGGGGGCAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGAGCA GCCCACTGAGAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGACAGC GCCTGAGGATGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAGCTCTTTCATCCTTCATTACCCCA GTTACCTTCTGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGTCAG AAGAGAGAGTCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCACCT GGACTCCTTCGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAGCAC CGTGAAAACCTGAAGGGGAGAGGGATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCT CACGTCGCCTTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATGATGCCAG TACAGTTTGATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGGCCC AGGAATCGTGTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTAGCA TTTAATGTTGTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTTTTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGG AGAGGAAGGTATAATTGAGCAAAACGTGTCCAGAGGACCCATGGCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGT GTGCTTGGCATTGTGCCCACAGCACTGCTGTCGTGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTG GGTTGAAATCCACAGCCCCGGTTGAGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCT GAAGTGACTGGGAGGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACC ACCTGGAAATGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTGGGA GCCAGTCTAGTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAAGTA CGGGAATCTTAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAAACAACTTCACAACAGCATGGCAAGGGG GGATGTGGAACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCAATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTT TTCTAGTTGGCATCCGGCACTGCAGAAAACTAAAAGTCATCCAGCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAG CTCAGAATGCCTCTGAGAACCAGAATCACTCCTTTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTG AAAATGCATCCTAAAAATTCAATGTTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATACAT CCCTCCCAGATTGCATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCA GAAGGACCCAGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGCTTC TGGTGAGAAGGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCAGGC CCACCCCCACAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAGCAGTCACAGAAATCATTCTTCCTGCTG TACTGGGCCTTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCAGAGCCACCGAAGGAAAACACAGCCAAGTTTAATAATAAT AAAAGGAAAAATCTCAGCCTGCAGAACTCTGGTTTTGACCCACCATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAA AGCAGGGCTCGTAATAGACTCCAGCACATTCCATCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGC AGGAGTCATAAGGAGTGATAACCTAAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTT GATCCTGTCACAGATATAACCCTGATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTCTTC |
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FusionGenePPI for DHX15_CCDC149 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHX15 | RNU11, SF3A2, TAF10, TOPORS, TADA2A, MYC, HDAC5, YWHAB, YWHAG, PINX1, HDGF, ARRB2, SIRT7, HNRNPA1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, GRK5, SF3B6, SNRPD2, SF3A1, SRSF1, DDX5, PABPC1, SRSF5, HNRNPF, SYNCRIP, SRSF3, CDC5L, SNW1, ACIN1, SRSF7, SRRM2, DEK, HNRNPK, RBMX, NOP58, RPL31, NOP56, SUPT16H, FBL, VTN, ECSIT, GTF3C1, NDUFAF4, PFN2, TMEM126B, S100A9, SENP3, EIF2D, MMGT1, RPL36, SLC30A9, PCDHA2, RANBP2, SRSF10, LBR, EBNA1BP2, PEX3, NXF1, FUT8, IWS1, RPL22, ESR1, NOTCH1, EIF4A3, MAGOH, UBC, POLR2C, FN1, VCAM1, RBM17, RBM10, RBM5, SUGP1, DDX42, TRA2A, NKAP, ITGA4, CD81, IGSF8, NPM1, SRPK2, SRPK3, FBXO6, PRPF40A, WBP4, APBB1, PIN1, AHCY, FH, MSN, NSFL1C, PCNA, PPP1CB, MCTS1, PAPSS1, TMOD3, RPA1, RPA2, RPA3, WWOX, NUDCD1, STAU1, CEP250, CEP57, FUS, ZGPAT, ENO1, MOV10, CUL7, OBSL1, EED, EPB41L3, UNK, NTRK1, ATXN2, DDX17, DDX43, DDX18, DHX37, GGA1, HNRNPL, ILK, KHDRBS1, KIAA0020, NDRG1, PUS7, SRRM1, TXLNA, UFD1L, XAB2, DKC1, DNAJC9, HNRNPR, KIAA1143, MSH2, NEMF, NOC2L, NOL6, NOLC1, PABPC4, PES1, PRPF19, PRPF4, PRPF8, RBM15, RBM15B, RPF2, RPL12, RSU1, SEC31A, SF3A3, SF3B1, SF3B3, SKIV2L2, SNRNP200, SNRPA1, SRSF11, TDRD3, TRMT112, TTC27, USP3, WDR36, ZYX, RNU12, SFN, KIFAP3, CRY2, ALKBH3, MCM5, MCM2, NF2, USP37, U2AF2, ZNF746, KNOP1, NCL, CYLD, CD2BP2, INO80B, UBE2A, BRCA1, LMNA, RNF168, MTF1 | CCDC149 | PRNP, APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHX15_CCDC149 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX15_CCDC149 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DHX15 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
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