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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9893

FusionGeneSummary for DHRS4_MANBA

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS4_MANBA
Fusion gene ID: 9893
HgeneTgene
Gene symbol

DHRS4

MANBA

Gene ID

10901

4126

Gene namedehydrogenase/reductase 4mannosidase beta
SynonymsCR|NRDR|PHCR|PSCD|SCAD-SRL|SDR-SRL|SDR25C1|SDR25C2MANB1
Cytomap

14q11.2

4q24

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 4NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Aperoxisomal short-chain alcohol dehydrogenasesbeta-mannosidasebeta-mannosidase Alysosomal beta A mannosidasemannanasemannasemannosidase, beta A, lysosomal
Modification date2018052220180523
UniProtAcc

Q9BTZ2

O00462

Ensembl transtripts involved in fusion geneENST00000313250, ENST00000558263, 
ENST00000543741, ENST00000382761, 
ENST00000397073, ENST00000308178, 
ENST00000421831, ENST00000397075, 
ENST00000397074, ENST00000559632, 
ENST00000558581, 
ENST00000226578, 
ENST00000505239, 
Fusion gene scores* DoF score2 X 1 X 2=44 X 4 X 4=64
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHRS4 [Title/Abstract] AND MANBA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHRS4

GO:0006066

alcohol metabolic process

18571493

HgeneDHRS4

GO:0008202

steroid metabolic process

18571493

HgeneDHRS4

GO:0042180

cellular ketone metabolic process

18571493

HgeneDHRS4

GO:0051262

protein tetramerization

18571493

HgeneDHRS4

GO:0055114

oxidation-reduction process

19442656


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7781-01ADHRS4chr14

24423125

+MANBAchr4

103647840

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313250ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000313250ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000558263ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000558263ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000543741ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000543741ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000382761ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000382761ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397073ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397073ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000308178ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000308178ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000421831ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000421831ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397075ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397075ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397074ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000397074ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000559632ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000559632ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000558581ENST00000226578DHRS4chr14

24423125

+MANBAchr4

103647840

-
Frame-shiftENST00000558581ENST00000505239DHRS4chr14

24423125

+MANBAchr4

103647840

-

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FusionProtFeatures for DHRS4_MANBA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHRS4

Q9BTZ2

MANBA

O00462

Exoglycosidase that cleaves the single beta-linkedmannose residue from the non-reducing end of all N-linkedglycoprotein oligosaccharides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DHRS4_MANBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DHRS4_MANBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHRS4RICTOR, PEX5, PEX14, TP53, PRDX3, DHRS4L2, PLAUR, C1QTNF9, NDUFA10, QPCT, PRELP, MRPL37, BIRC7, ALDH1B1, OXSM, DHRS4, CLPB, NDUFAF5, ABHD11, BOLA1, NDUFA5, CHCHD2, MRPL13, PMPCA, NDUFS2, WBSCR16, EHHADH, PITRM1, PHYHIPL, PMPCB, NDUFAF3, NDUFS3, POLDIP2, NRD1, ECH1, BCKDHA, ATP5E, GLRX5, C17orf89, DUSP13, SUN2, ACADVL, TRIM43, HEXA, LMO2, FAM60A, KLHL6, ATP5D, CYP2B6, TMEM70, PDHA1MANBAFBXO6, KLK11, TAZ, KIRREL2, CLEC18A, DNASE2B, PTPRK, SIAE, LIPH, GPHA2, SCGB1D1, FAM19A3, DEFA1, C4orf26, PRSS37, ADAMTS4, LYZL2, LYZL1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHRS4_MANBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDHRS4Q9BTZ2DB00162Vitamin ADehydrogenase/reductase SDR family member 4small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for DHRS4_MANBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource