![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9893 |
FusionGeneSummary for DHRS4_MANBA |
![]() |
Fusion gene information | Fusion gene name: DHRS4_MANBA | Fusion gene ID: 9893 | Hgene | Tgene | Gene symbol | DHRS4 | MANBA | Gene ID | 10901 | 4126 |
Gene name | dehydrogenase/reductase 4 | mannosidase beta | |
Synonyms | CR|NRDR|PHCR|PSCD|SCAD-SRL|SDR-SRL|SDR25C1|SDR25C2 | MANB1 | |
Cytomap | 14q11.2 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | dehydrogenase/reductase SDR family member 4NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Aperoxisomal short-chain alcohol dehydrogenases | beta-mannosidasebeta-mannosidase Alysosomal beta A mannosidasemannanasemannasemannosidase, beta A, lysosomal | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9BTZ2 | O00462 | |
Ensembl transtripts involved in fusion gene | ENST00000313250, ENST00000558263, ENST00000543741, ENST00000382761, ENST00000397073, ENST00000308178, ENST00000421831, ENST00000397075, ENST00000397074, ENST00000559632, ENST00000558581, | ENST00000226578, ENST00000505239, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 4 X 4=64 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DHRS4 [Title/Abstract] AND MANBA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DHRS4 | GO:0006066 | alcohol metabolic process | 18571493 |
Hgene | DHRS4 | GO:0008202 | steroid metabolic process | 18571493 |
Hgene | DHRS4 | GO:0042180 | cellular ketone metabolic process | 18571493 |
Hgene | DHRS4 | GO:0051262 | protein tetramerization | 18571493 |
Hgene | DHRS4 | GO:0055114 | oxidation-reduction process | 19442656 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-7781-01A | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000313250 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000313250 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000558263 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000558263 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000543741 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000543741 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000382761 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000382761 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397073 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397073 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000308178 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000308178 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000421831 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000421831 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397075 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397075 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397074 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000397074 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000559632 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000559632 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000558581 | ENST00000226578 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Frame-shift | ENST00000558581 | ENST00000505239 | DHRS4 | chr14 | 24423125 | + | MANBA | chr4 | 103647840 | - |
Top |
FusionProtFeatures for DHRS4_MANBA |
![]() |
Hgene | Tgene |
DHRS4 | MANBA |
Exoglycosidase that cleaves the single beta-linkedmannose residue from the non-reducing end of all N-linkedglycoprotein oligosaccharides. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DHRS4_MANBA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for DHRS4_MANBA |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DHRS4 | RICTOR, PEX5, PEX14, TP53, PRDX3, DHRS4L2, PLAUR, C1QTNF9, NDUFA10, QPCT, PRELP, MRPL37, BIRC7, ALDH1B1, OXSM, DHRS4, CLPB, NDUFAF5, ABHD11, BOLA1, NDUFA5, CHCHD2, MRPL13, PMPCA, NDUFS2, WBSCR16, EHHADH, PITRM1, PHYHIPL, PMPCB, NDUFAF3, NDUFS3, POLDIP2, NRD1, ECH1, BCKDHA, ATP5E, GLRX5, C17orf89, DUSP13, SUN2, ACADVL, TRIM43, HEXA, LMO2, FAM60A, KLHL6, ATP5D, CYP2B6, TMEM70, PDHA1 | MANBA | FBXO6, KLK11, TAZ, KIRREL2, CLEC18A, DNASE2B, PTPRK, SIAE, LIPH, GPHA2, SCGB1D1, FAM19A3, DEFA1, C4orf26, PRSS37, ADAMTS4, LYZL2, LYZL1, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DHRS4_MANBA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | DHRS4 | Q9BTZ2 | DB00162 | Vitamin A | Dehydrogenase/reductase SDR family member 4 | small molecule | approved|nutraceutical|vet_approved |
Top |
RelatedDiseases for DHRS4_MANBA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |