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Fusion gene ID: 9892 |
FusionGeneSummary for DHRS4L2_RNF31 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHRS4L2_RNF31 | Fusion gene ID: 9892 | Hgene | Tgene | Gene symbol | DHRS4L2 | RNF31 | Gene ID | 317749 | 55072 |
| Gene name | dehydrogenase/reductase 4 like 2 | ring finger protein 31 | |
| Synonyms | SDR25C3 | HOIP|Paul|ZIBRA | |
| Cytomap | 14q11.2 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dehydrogenase/reductase SDR family member 4-like 2NADP(H)-dependent retinol dehydrogenase/reductase short isoform-like proteinNADPH-dependent retinol dehydrogenase/reductase-like protein 2dehydrogenase/reductase (SDR family) member 4 like 2dehydrogena | E3 ubiquitin-protein ligase RNF31HOIL-1-interacting proteinRING-type E3 ubiquitin transferase RNF31zinc in-between-RING-finger ubiquitin-associated domain protein | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q6PKH6 | Q96EP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000534993, ENST00000543805, ENST00000397071, ENST00000335125, ENST00000558753, ENST00000537912, ENST00000545240, ENST00000382755, | ENST00000557878, ENST00000559275, ENST00000324103, ENST00000382687, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 4=100 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHRS4L2 [Title/Abstract] AND RNF31 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RNF31 | GO:0000209 | protein polyubiquitination | 12629548|17006537 |
| Tgene | RNF31 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19136968|21455173 |
| Tgene | RNF31 | GO:0050852 | T cell receptor signaling pathway | 20005846 |
| Tgene | RNF31 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 19136968 |
| Tgene | RNF31 | GO:0097039 | protein linear polyubiquitination | 21455173|21455180|21455181|23453807 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-KQ-A41R-01A | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000534993 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000534993 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000534993 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000534993 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000543805 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000543805 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000543805 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000543805 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000397071 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000397071 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000397071 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000397071 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000335125 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000335125 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000335125 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000335125 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000558753 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000558753 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000558753 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000558753 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000537912 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000537912 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000537912 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| intron-intron | ENST00000537912 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000545240 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000545240 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000545240 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000545240 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000382755 | ENST00000557878 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000382755 | ENST00000559275 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000382755 | ENST00000324103 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
| 5CDS-intron | ENST00000382755 | ENST00000382687 | DHRS4L2 | chr14 | 24464342 | + | RNF31 | chr14 | 24626499 | + |
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FusionProtFeatures for DHRS4L2_RNF31 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHRS4L2 | RNF31 |
| Probable oxidoreductase. {ECO:0000250}. | E3 ubiquitin-protein ligase component of the LUBACcomplex which conjugates linear ('Met-1'-linked) polyubiquitinchains to substrates and plays a key role in NF-kappa-B activationand regulation of inflammation (PubMed:17006537, PubMed:19136968,PubMed:20005846, PubMed:21455173, PubMed:21455180,PubMed:21455181, PubMed:22863777). LUBAC conjugates linearpolyubiquitin to IKBKG and RIPK1 and is involved in activation ofthe canonical NF-kappa-B and the JNK signaling pathways(PubMed:17006537, PubMed:19136968, PubMed:20005846,PubMed:21455173, PubMed:21455180, PubMed:21455181,PubMed:22863777). Linear ubiquitination mediated by the LUBACcomplex interferes with TNF-induced cell death and therebyprevents inflammation (PubMed:21455173). LUBAC is proposed to berecruited to the TNF-R1 signaling complex (TNF-RSC) followingpolyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 andto conjugate linear polyubiquitin to IKBKG and possibly othercomponents contributing to the stability of the complex(PubMed:20005846). Together with otulin, the LUBAC complexregulates the canonical Wnt signaling during angiogenesis. Bindspolyubiquitin of different linkage types (PubMed:23708998).{ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968,ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173,ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181,ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHRS4L2_RNF31 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHRS4L2_RNF31 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHRS4L2 | MTIF2, AARS2, DHRS4, ZZEF1, ACOT7, D2HGDH | RNF31 | TNF, RBCK1, ATXN7, AZI2, TRAF1, TRIM25, DDX58, NOD2, RIPK2, NR0B1, NR0B2, PRKCB, ATN1, ATXN1, GFI1B, TNFAIP3, IKBKG, SHARPIN, UBE2D1, UBE2D3, NOS3, BIRC2, BIRC3, UBC, OTULIN, SMAD3, SOCS3, VCP, NDUFA8, TRAF2, CCDC14, WRNIP1, AKAP8L, ESR1, RNF31, IRAK1, MALT1, KIF1A, PITX1, PRKCA, AES, SNRPC, TSSC4, KRTAP9-2, VASN, CCDC24, UBE2D2, UBE2L3, CD40, ENDOV, ARHGEF10, PPARD, LIPF, LTBR, LDLRAD4, NTRK1, CYLD, RIPK1, TNFRSF1A, PDLIM7, IRF7, CARD11, BCL10, TLR3, SPATA2, LMO2, RABGEF1, FKBPL, SNTG2, KIAA1683, PRIM2, GBP1, PRIM1, ZNF785, ACTBL2, SEPT2, HDAC6, VDAC1, TRAF6, PARK2, MAVS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHRS4L2_RNF31 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHRS4L2_RNF31 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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