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Fusion gene ID: 9888 |
FusionGeneSummary for DHRS1_METTL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHRS1_METTL3 | Fusion gene ID: 9888 | Hgene | Tgene | Gene symbol | DHRS1 | METTL3 | Gene ID | 115817 | 56339 |
| Gene name | dehydrogenase/reductase 1 | methyltransferase like 3 | |
| Synonyms | SDR19C1 | IME4|M6A|MT-A70|Spo8|hMETTL3 | |
| Cytomap | 14q12 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dehydrogenase/reductase SDR family member 1dehydrogenase/reductase (SDR family) member 1short chain dehydrogenase/reductase family 19C member 1 | N6-adenosine-methyltransferase catalytic subunitN6-adenosine-methyltransferase 70 kDa subunitadoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferasemRNA (2'-O-methyladenosine-N(6)-)-methyltransferasemRNA m(6)A methyltransferasemethy | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96LJ7 | Q86U44 | |
| Ensembl transtripts involved in fusion gene | ENST00000559088, ENST00000288111, ENST00000396813, | ENST00000298717, ENST00000538267, ENST00000545319, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DHRS1 [Title/Abstract] AND METTL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | METTL3 | GO:0006974 | cellular response to DNA damage stimulus | 28297716 |
| Tgene | METTL3 | GO:0031053 | primary miRNA processing | 25799998 |
| Tgene | METTL3 | GO:0034644 | cellular response to UV | 28297716 |
| Tgene | METTL3 | GO:0080009 | mRNA methylation | 24316715|27281194|27373337|27627798|28297716 |
| Tgene | METTL3 | GO:1990744 | primary miRNA methylation | 25799998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-39-5019-01A | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000559088 | ENST00000298717 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| intron-3UTR | ENST00000559088 | ENST00000538267 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| intron-intron | ENST00000559088 | ENST00000545319 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| In-frame | ENST00000288111 | ENST00000298717 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| 5CDS-3UTR | ENST00000288111 | ENST00000538267 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| 5CDS-intron | ENST00000288111 | ENST00000545319 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| Frame-shift | ENST00000396813 | ENST00000298717 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| 5CDS-3UTR | ENST00000396813 | ENST00000538267 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
| 5CDS-intron | ENST00000396813 | ENST00000545319 | DHRS1 | chr14 | 24768163 | - | METTL3 | chr14 | 21970045 | - |
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FusionProtFeatures for DHRS1_METTL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHRS1 | METTL3 |
| The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues atthe N(6) position of some RNAs and regulates various processessuch as the circadian clock, differentiation of embryonic andhaematopoietic stem cells, cortical neurogenesis, response to DNAdamage, differentiation of T-cells and primary miRNA processing(PubMed:22575960, PubMed:24284625, PubMed:25719671,PubMed:25799998, PubMed:26321680, PubMed:26593424,PubMed:27627798, PubMed:27373337, PubMed:27281194,PubMed:28297716, PubMed:29506078, PubMed:29348140,PubMed:9409616). In the heterodimer formed with METTL14, METTL3constitutes the catalytic core (PubMed:27627798, PubMed:27373337,PubMed:27281194). N6-methyladenosine (m6A), which takes place atthe 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role inmRNA stability, processing, translation efficiency and editing(PubMed:22575960, PubMed:24284625, PubMed:25719671,PubMed:25799998, PubMed:26321680, PubMed:26593424,PubMed:28297716, PubMed:9409616). M6A acts as a key regulator ofmRNA stability: methylation is completed upon the release of mRNAinto the nucleoplasm and promotes mRNA destabilization anddegradation (PubMed:28637692). In embryonic stem cells (ESCs), m6Amethylation of mRNAs encoding key naive pluripotency-promotingtranscripts results in transcript destabilization, promotingdifferentiation of ESCs (By similarity). M6A regulates the lengthof the circadian clock: acts as an early pace-setter in thecircadian loop by putting mRNA production on a fast-track forfacilitating nuclear processing, thereby providing an early pointof control in setting the dynamics of the feedback loop (Bysimilarity). M6A regulates spermatogonial differentiation andmeiosis and is essential for male fertility and spermatogenesis(By similarity). Involved in the response to DNA damage: inresponse to ultraviolet irradiation, METTL3 rapidly catalyzes theformation of m6A on poly(A) transcripts at DNA damage sites,leading to the recruitment of POLK to DNA damage sites(PubMed:28297716). M6A is also required for T-cell homeostasis anddifferentiation: m6A methylation of transcripts of SOCS familymembers (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNAdestabilization and degradation, promoting T-cell differentiation(By similarity). M6A also takes place in other RNA molecules, suchas primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6Amethylation of Xist RNA, thereby participating in random Xinactivation: m6A methylation of Xist leads to target YTHDC1reader on Xist and promote transcription repression activity ofXist (PubMed:27602518). M6A also regulates cortical neurogenesis:m6A methylation of transcripts related to transcription factors,neural stem cells, the cell cycle and neuronal differentiationduring brain development promotes their destabilization and decay,promoting differentiation of radial glial cells (By similarity).METTL3 mediates methylation of pri-miRNAs, marking them forrecognition and processing by DGCR8 (PubMed:25799998). Acts as apositive regulator of mRNA translation independently of themethyltransferase activity: promotes translation by interactingwith the translation initiation machinery in the cytoplasm(PubMed:27117702). Its overexpression in a number of cancer cellssuggests that it may participate to cancer cell proliferation bypromoting mRNA translation (PubMed:27117702).{ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960,ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671,ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680,ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702,ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337,ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798,ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692,ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078,ECO:0000269|PubMed:9409616}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHRS1_METTL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DHRS1_ENST00000288111_chr14_24768163_-_METTL3_ENST00000298717_chr14_21970045_-_390aa MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTK EECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPP QWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTN QLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DHRS1_ENST00000288111_chr14_24768163_-_METTL3_ENST00000298717_chr14_21970045_-_1170nt ATGGCAGCTCCCATGAATGGCCAAGTGTGTGTGGTGACTGGTGCCTCCAGGGGTATTGGCCGTGGCATTGCCTTGCAGCTCTGCAAAGCA GGCGCCACAGTTTACATCACTGGCCGCCATCTGGACACCCTTCGCGTTGTTGCTCAGGAGGTCAGTCAGGAGATCCTAGAGCTATTAAAT ACTACAACAGCCAAGGAACAATCCATTGTTGAAAAATTTCGCTCTCGAGGTCGGGCCCAAGTGCAAGAATTCTGTGACTATGGAACCAAG GAGGAGTGCATGAAAGCCAGTGATGCTGATCGACCCTGTCGCAAGCTGCACTTCAGACGAATTATCAATAAACACACTGATGAGTCTTTA GGTGACTGCTCTTTCCTTAATACATGTTTCCACATGGATACCTGCAAGTATGTTCACTATGAAATTGATGCTTGCATGGATTCTGAGGCC CCTGGCAGCAAAGACCACACGCCAAGCCAGGAGCTTGCTCTTACACAGAGTGTCGGAGGTGATTCCAGTGCAGACCGACTCTTCCCACCT CAGTGGATCTGTTGTGATATCCGCTACCTGGACGTCAGTATCTTGGGCAAGTTTGCAGTTGTGATGGCTGACCCACCCTGGGATATTCAC ATGGAACTGCCCTATGGGACCCTGACAGATGATGAGATGCGCAGGCTCAACATACCCGTACTACAGGATGATGGCTTTCTCTTCCTCTGG GTCACAGGCAGGGCCATGGAGTTGGGGAGAGAATGTCTAAATCTCTGGGGGTATGAACGGGTAGATGAAATTATTTGGGTGAAGACAAAT CAACTGCAACGCATCATTCGGACAGGCCGTACAGGTCACTGGTTGAACCATGGGAAGGAACACTGCTTGGTTGGTGTCAAAGGAAATCCC CAAGGCTTCAACCAGGGTCTGGATTGTGATGTGATCGTAGCTGAGGTTCGTTCCACCAGTCATAAACCAGATGAAATCTATGGCATGATT GAAAGACTATCTCCTGGCACTCGCAAGATTGAGTTATTTGGACGACCACACAATGTGCAACCCAACTGGATCACCCTTGGAAACCAACTG GATGGGATCCACCTACTAGACCCAGATGTGGTTGCACGGTTCAAGCAAAGGTACCCAGATGGTATCATCTCTAAACCTAAGAATTTATAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DHRS1_ENST00000288111_chr14_24768163_-_METTL3_ENST00000298717_chr14_21970045_-_1567nt TACTACGTCATAGTTCCGCGCCGCCCCAGCCGGGCGGGGTGGGTGTGTCACCCAGATCGCTCCGCCCCCATCCGCAGGTTCTAACTTTGG CCTGGGACTCTGCCCCTCTACCTCAGCACAGAATCGCCCCGGGTCCTACTACAGAATCAATCCTTGAACACTGCCTCCACGTCGCCGGCT CAATCTGGGCGAGAACCCAGACTTCCACCGCAGCCCCGCAATCTGCAGACCTCAGCGGCAGCGCAGGTGGCAGACCTGCCTCCTTTGCCT GTGAGTCATGGCAGCTCCCATGAATGGCCAAGTGTGTGTGGTGACTGGTGCCTCCAGGGGTATTGGCCGTGGCATTGCCTTGCAGCTCTG CAAAGCAGGCGCCACAGTTTACATCACTGGCCGCCATCTGGACACCCTTCGCGTTGTTGCTCAGGAGGTCAGTCAGGAGATCCTAGAGCT ATTAAATACTACAACAGCCAAGGAACAATCCATTGTTGAAAAATTTCGCTCTCGAGGTCGGGCCCAAGTGCAAGAATTCTGTGACTATGG AACCAAGGAGGAGTGCATGAAAGCCAGTGATGCTGATCGACCCTGTCGCAAGCTGCACTTCAGACGAATTATCAATAAACACACTGATGA GTCTTTAGGTGACTGCTCTTTCCTTAATACATGTTTCCACATGGATACCTGCAAGTATGTTCACTATGAAATTGATGCTTGCATGGATTC TGAGGCCCCTGGCAGCAAAGACCACACGCCAAGCCAGGAGCTTGCTCTTACACAGAGTGTCGGAGGTGATTCCAGTGCAGACCGACTCTT CCCACCTCAGTGGATCTGTTGTGATATCCGCTACCTGGACGTCAGTATCTTGGGCAAGTTTGCAGTTGTGATGGCTGACCCACCCTGGGA TATTCACATGGAACTGCCCTATGGGACCCTGACAGATGATGAGATGCGCAGGCTCAACATACCCGTACTACAGGATGATGGCTTTCTCTT CCTCTGGGTCACAGGCAGGGCCATGGAGTTGGGGAGAGAATGTCTAAATCTCTGGGGGTATGAACGGGTAGATGAAATTATTTGGGTGAA GACAAATCAACTGCAACGCATCATTCGGACAGGCCGTACAGGTCACTGGTTGAACCATGGGAAGGAACACTGCTTGGTTGGTGTCAAAGG AAATCCCCAAGGCTTCAACCAGGGTCTGGATTGTGATGTGATCGTAGCTGAGGTTCGTTCCACCAGTCATAAACCAGATGAAATCTATGG CATGATTGAAAGACTATCTCCTGGCACTCGCAAGATTGAGTTATTTGGACGACCACACAATGTGCAACCCAACTGGATCACCCTTGGAAA CCAACTGGATGGGATCCACCTACTAGACCCAGATGTGGTTGCACGGTTCAAGCAAAGGTACCCAGATGGTATCATCTCTAAACCTAAGAA TTTATAGAAGCACTTCCTTACAGAGCTAAGAATCCATAGCCATGGCTCTGTAAGCTAAACCTGAAGAGTGATATTTGTACAATAGCTTTC |
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FusionGenePPI for DHRS1_METTL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHRS1 | MDFI, PLSCR1, CDK2, KRTAP5-9, KRTAP3-2, KRTAP10-8, KRTAP10-3, NOTCH2NL | METTL3 | METTL14, MOV10, HIST1H2BG, CEP19, ROBO2, SEL1L, WTAP, RBM15B, PPHLN1, MPP1, MYC, ACTR2, SNW1, NSUN2, ARNTL2, SIRT6, LGALS7, OLFM2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHRS1_METTL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHRS1_METTL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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