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Fusion gene ID: 9887 |
FusionGeneSummary for DHRS13_PHF12 |
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Fusion gene information | Fusion gene name: DHRS13_PHF12 | Fusion gene ID: 9887 | Hgene | Tgene | Gene symbol | DHRS13 | PHF12 | Gene ID | 147015 | 57649 |
Gene name | dehydrogenase/reductase 13 | PHD finger protein 12 | |
Synonyms | SDR7C5 | PF1 | |
Cytomap | 17q11.2 | 17q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dehydrogenase/reductase SDR family member 13dehydrogenase/reductase (SDR family) member 13short chain dehydrogenase/reductase family 7C member 5 | PHD finger protein 12PHD factor 1PHD zinc finger transcription factor | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6UX07 | Q96QT6 | |
Ensembl transtripts involved in fusion gene | ENST00000394901, ENST00000378895, ENST00000426464, ENST00000581974, | ENST00000332830, ENST00000577226, ENST00000268756, ENST00000582655, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 6 X 5=210 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DHRS13 [Title/Abstract] AND PHF12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PHF12 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 22048773 |
Tgene | PHF12 | GO:0045892 | negative regulation of transcription, DNA-templated | 11390640 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-1910-01A | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000394901 | ENST00000332830 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
In-frame | ENST00000394901 | ENST00000577226 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
In-frame | ENST00000394901 | ENST00000268756 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
5CDS-5UTR | ENST00000394901 | ENST00000582655 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
In-frame | ENST00000378895 | ENST00000332830 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
In-frame | ENST00000378895 | ENST00000577226 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
In-frame | ENST00000378895 | ENST00000268756 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
5CDS-5UTR | ENST00000378895 | ENST00000582655 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000426464 | ENST00000332830 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000426464 | ENST00000577226 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000426464 | ENST00000268756 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-5UTR | ENST00000426464 | ENST00000582655 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000581974 | ENST00000332830 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000581974 | ENST00000577226 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-3CDS | ENST00000581974 | ENST00000268756 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
intron-5UTR | ENST00000581974 | ENST00000582655 | DHRS13 | chr17 | 27229601 | - | PHF12 | chr17 | 27241055 | - |
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FusionProtFeatures for DHRS13_PHF12 |
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Hgene | Tgene |
DHRS13 | PHF12 |
Putative oxidoreductase. {ECO:0000305}. | Acts as a transcriptional repressor. Involved inrecruitment of functional SIN3A complexes to DNA. Repressestranscription at least in part through the activity of anassociated histone deacetylase (HDAC). May also represstranscription in a SIN3A-independent manner through recruitment offunctional AES complexes to DNA. {ECO:0000269|PubMed:11390640,ECO:0000303|PubMed:11390640}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DHRS13 | chr17:27229601 | chr17:27241055 | ENST00000378895 | - | 2 | 5 | 43_49 | 82 | 378 | Nucleotide binding | NAD or NADP |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 894_897 | 378 | 705 | Compositional bias | Poly-Arg |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 929_932 | 378 | 705 | Compositional bias | Poly-Ser |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 894_897 | 378 | 1005 | Compositional bias | Poly-Arg |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 929_932 | 378 | 1005 | Compositional bias | Poly-Ser |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 815_869 | 378 | 705 | Domain | FHA |
Tgene | >PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 815_869 | 378 | 1005 | Domain | FHA |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DHRS13 | chr17:27229601 | chr17:27241055 | ENST00000394901 | - | 1 | 4 | 43_49 | 32 | 328 | Nucleotide binding | NAD or NADP |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 105_128 | 378 | 705 | Region | Note=PBR |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 105_128 | 378 | 1005 | Region | Note=PBR |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 271_321 | 378 | 705 | Zinc finger | PHD-type 2%3B atypical |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 56_105 | 378 | 705 | Zinc finger | PHD-type 1 |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 271_321 | 378 | 1005 | Zinc finger | PHD-type 2%3B atypical |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 56_105 | 378 | 1005 | Zinc finger | PHD-type 1 |
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FusionGeneSequence for DHRS13_PHF12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHRS13_PHF12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DHRS13 | KIAA1279, SLC39A4, KIF11, TNFSF8, RANBP6 | PHF12 | SIN3A, HDAC1, SAP30, MORF4L1, MORF4L2, BRCA1, HIST3H3, GATAD1, RBBP7, HDAC2, KDM5A, S100A4, SIN3B, C11orf30, SPICE1, ZNF281, ZNF131, QSER1, CHD9, PHF12, TUBA4A, ZNF143, DPM1, ZNF335, RBFOX2, RBFOX1, H2AFY, BAG2, HSPB1, NFE2L1, TUBB8, DNAJA3, SENP1, ABCF2, GPATCH8, ABCG2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 102_273 | 378 | 705 | SIN3A |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000268756 | - | 6 | 9 | 300_704 | 378 | 705 | SIN3A |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 102_273 | 378 | 1005 | SIN3A |
Tgene | PHF12 | chr17:27229601 | chr17:27241055 | ENST00000332830 | - | 6 | 15 | 300_704 | 378 | 1005 | SIN3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHRS13_PHF12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHRS13_PHF12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |