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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9887

FusionGeneSummary for DHRS13_PHF12

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS13_PHF12
Fusion gene ID: 9887
HgeneTgene
Gene symbol

DHRS13

PHF12

Gene ID

147015

57649

Gene namedehydrogenase/reductase 13PHD finger protein 12
SynonymsSDR7C5PF1
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 13dehydrogenase/reductase (SDR family) member 13short chain dehydrogenase/reductase family 7C member 5PHD finger protein 12PHD factor 1PHD zinc finger transcription factor
Modification date2018051920180523
UniProtAcc

Q6UX07

Q96QT6

Ensembl transtripts involved in fusion geneENST00000394901, ENST00000378895, 
ENST00000426464, ENST00000581974, 
ENST00000332830, ENST00000577226, 
ENST00000268756, ENST00000582655, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 6 X 5=210
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHRS13 [Title/Abstract] AND PHF12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePHF12

GO:0000122

negative regulation of transcription by RNA polymerase II

22048773

TgenePHF12

GO:0045892

negative regulation of transcription, DNA-templated

11390640


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1910-01ADHRS13chr17

27229601

-PHF12chr17

27241055

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394901ENST00000332830DHRS13chr17

27229601

-PHF12chr17

27241055

-
In-frameENST00000394901ENST00000577226DHRS13chr17

27229601

-PHF12chr17

27241055

-
In-frameENST00000394901ENST00000268756DHRS13chr17

27229601

-PHF12chr17

27241055

-
5CDS-5UTRENST00000394901ENST00000582655DHRS13chr17

27229601

-PHF12chr17

27241055

-
In-frameENST00000378895ENST00000332830DHRS13chr17

27229601

-PHF12chr17

27241055

-
In-frameENST00000378895ENST00000577226DHRS13chr17

27229601

-PHF12chr17

27241055

-
In-frameENST00000378895ENST00000268756DHRS13chr17

27229601

-PHF12chr17

27241055

-
5CDS-5UTRENST00000378895ENST00000582655DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000426464ENST00000332830DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000426464ENST00000577226DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000426464ENST00000268756DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-5UTRENST00000426464ENST00000582655DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000581974ENST00000332830DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000581974ENST00000577226DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-3CDSENST00000581974ENST00000268756DHRS13chr17

27229601

-PHF12chr17

27241055

-
intron-5UTRENST00000581974ENST00000582655DHRS13chr17

27229601

-PHF12chr17

27241055

-

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FusionProtFeatures for DHRS13_PHF12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHRS13

Q6UX07

PHF12

Q96QT6

Putative oxidoreductase. {ECO:0000305}. Acts as a transcriptional repressor. Involved inrecruitment of functional SIN3A complexes to DNA. Repressestranscription at least in part through the activity of anassociated histone deacetylase (HDAC). May also represstranscription in a SIN3A-independent manner through recruitment offunctional AES complexes to DNA. {ECO:0000269|PubMed:11390640,ECO:0000303|PubMed:11390640}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS13chr17:27229601chr17:27241055ENST00000378895-2543_4982378Nucleotide bindingNAD or NADP
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69894_897378705Compositional biasPoly-Arg
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69929_932378705Compositional biasPoly-Ser
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615894_8973781005Compositional biasPoly-Arg
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615929_9323781005Compositional biasPoly-Ser
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69815_869378705DomainFHA
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615815_8693781005DomainFHA

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS13chr17:27229601chr17:27241055ENST00000394901-1443_4932328Nucleotide bindingNAD or NADP
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69105_128378705RegionNote=PBR
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615105_1283781005RegionNote=PBR
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69271_321378705Zinc fingerPHD-type 2%3B atypical
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-6956_105378705Zinc fingerPHD-type 1
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615271_3213781005Zinc fingerPHD-type 2%3B atypical
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-61556_1053781005Zinc fingerPHD-type 1


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FusionGeneSequence for DHRS13_PHF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DHRS13_PHF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHRS13KIAA1279, SLC39A4, KIF11, TNFSF8, RANBP6PHF12SIN3A, HDAC1, SAP30, MORF4L1, MORF4L2, BRCA1, HIST3H3, GATAD1, RBBP7, HDAC2, KDM5A, S100A4, SIN3B, C11orf30, SPICE1, ZNF281, ZNF131, QSER1, CHD9, PHF12, TUBA4A, ZNF143, DPM1, ZNF335, RBFOX2, RBFOX1, H2AFY, BAG2, HSPB1, NFE2L1, TUBB8, DNAJA3, SENP1, ABCF2, GPATCH8, ABCG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69102_273378705SIN3A
TgenePHF12chr17:27229601chr17:27241055ENST00000268756-69300_704378705SIN3A
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615102_2733781005SIN3A
TgenePHF12chr17:27229601chr17:27241055ENST00000332830-615300_7043781005SIN3A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHRS13_PHF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DHRS13_PHF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource