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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9885

FusionGeneSummary for DHRS12_RASL11A

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS12_RASL11A
Fusion gene ID: 9885
HgeneTgene
Gene symbol

DHRS12

RASL11A

Gene ID

79758

387496

Gene namedehydrogenase/reductase 12RAS like family 11 member A
SynonymsSDR40C1-
Cytomap

13q14.3

13q12.2

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1ras-like protein family member 11A
Modification date2018051920180519
UniProtAcc

A0PJE2

Q6T310

Ensembl transtripts involved in fusion geneENST00000444610, ENST00000218981, 
ENST00000280056, ENST00000490949, 
ENST00000241463, ENST00000480803, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 1 X 2=4
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: DHRS12 [Title/Abstract] AND RASL11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GC-A3RC-01ADHRS12chr13

52373670

-RASL11Achr13

27845621

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000444610ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000444610ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
Frame-shiftENST00000218981ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000218981ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
Frame-shiftENST00000280056ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5CDS-intronENST00000280056ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5UTR-3CDSENST00000490949ENST00000241463DHRS12chr13

52373670

-RASL11Achr13

27845621

+
5UTR-intronENST00000490949ENST00000480803DHRS12chr13

52373670

-RASL11Achr13

27845621

+

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FusionProtFeatures for DHRS12_RASL11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHRS12

A0PJE2

RASL11A

Q6T310

Putative oxidoreductase. {ECO:0000250}. Regulator of rDNA transcription. Acts in cooperationUBF/UBTF and positively regulates RNA polymerase I transcription(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52373670chr13:27845621ENST00000444610-21047_5363318Nucleotide bindingNAD or NADP
TgeneRASL11Achr13:52373670chr13:27845621ENST00000241463+04147_15041243Nucleotide bindingGTP
TgeneRASL11Achr13:52373670chr13:27845621ENST00000241463+0481_8541243Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52373670chr13:27845621ENST00000218981-2847_5342243Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:27845621ENST00000280056-2847_5342272Nucleotide bindingNAD or NADP
TgeneRASL11Achr13:52373670chr13:27845621ENST00000241463+0434_4141243Nucleotide bindingGTP
TgeneRASL11Achr13:52373670chr13:27845621ENST00000241463+0417_24141243RegionNote=Small GTPase-like


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FusionGeneSequence for DHRS12_RASL11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_265aa
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRAMIVRFLTKRFIGDYEPNTGKLYSRLV
YVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_795nt
ATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCATGTAAAGACTTTGTC
CCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAACTGCCCTTGAAATC
GCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGTATTCACGGCTGGTC
TATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCCAGGTCGTCGATTCC
CTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCATCCGACCCCTTTAT
CAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATGCCCGGCAGGTGCAG
ACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAGATGTCTGTGATGTG
TTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTCGGCCCCGCTCTCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_1005nt
GGGGCGCTCCCGGCATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCAT
GTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAA
CTGCCCTTGAAATCGCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGT
ATTCACGGCTGGTCTATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCC
AGGTCGTCGATTCCCTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCA
TCCGACCCCTTTATCAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATG
CCCGGCAGGTGCAGACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAG
ATGTCTGTGATGTGTTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTC
GGCCCCGCTCTCCCAACATGCAGGACCTGAAGAGACGCTTCAAGCAGGCTCTGTCTCCCAAAGTCAAAGCCCCCTCTGCACTGGGGTGAA
CTATCTCAGACAGATGCCTCTCCTTTTTAATACGCATTTGTGCAGCTAAAAGACTGGGCTTCTCGCTTTTTAATCACACATTCAGAGTTT
ATTTTTATAAAAAAATTGATTTTCAAGTACATGTGTATTTCTGAAAATTCAAACAGTGATTGCCTAGAAGCTGGATAAAATTTTGTTTTG


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FusionGenePPI for DHRS12_RASL11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHRS12H3F3ARASL11AELAVL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHRS12_RASL11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DHRS12_RASL11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRASL11AC0014175Endometriosis1CTD_human