![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9885 |
FusionGeneSummary for DHRS12_RASL11A |
![]() |
Fusion gene information | Fusion gene name: DHRS12_RASL11A | Fusion gene ID: 9885 | Hgene | Tgene | Gene symbol | DHRS12 | RASL11A | Gene ID | 79758 | 387496 |
Gene name | dehydrogenase/reductase 12 | RAS like family 11 member A | |
Synonyms | SDR40C1 | - | |
Cytomap | 13q14.3 | 13q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1 | ras-like protein family member 11A | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | A0PJE2 | Q6T310 | |
Ensembl transtripts involved in fusion gene | ENST00000444610, ENST00000218981, ENST00000280056, ENST00000490949, | ENST00000241463, ENST00000480803, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 1 X 2=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: DHRS12 [Title/Abstract] AND RASL11A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-GC-A3RC-01A | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000444610 | ENST00000241463 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
5CDS-intron | ENST00000444610 | ENST00000480803 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
Frame-shift | ENST00000218981 | ENST00000241463 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
5CDS-intron | ENST00000218981 | ENST00000480803 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
Frame-shift | ENST00000280056 | ENST00000241463 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
5CDS-intron | ENST00000280056 | ENST00000480803 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
5UTR-3CDS | ENST00000490949 | ENST00000241463 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
5UTR-intron | ENST00000490949 | ENST00000480803 | DHRS12 | chr13 | 52373670 | - | RASL11A | chr13 | 27845621 | + |
Top |
FusionProtFeatures for DHRS12_RASL11A |
![]() |
Hgene | Tgene |
DHRS12 | RASL11A |
Putative oxidoreductase. {ECO:0000250}. | Regulator of rDNA transcription. Acts in cooperationUBF/UBTF and positively regulates RNA polymerase I transcription(By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DHRS12 | chr13:52373670 | chr13:27845621 | ENST00000444610 | - | 2 | 10 | 47_53 | 63 | 318 | Nucleotide binding | NAD or NADP |
Tgene | >RASL11A | chr13:52373670 | chr13:27845621 | ENST00000241463 | + | 0 | 4 | 147_150 | 41 | 243 | Nucleotide binding | GTP |
Tgene | >RASL11A | chr13:52373670 | chr13:27845621 | ENST00000241463 | + | 0 | 4 | 81_85 | 41 | 243 | Nucleotide binding | GTP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DHRS12 | chr13:52373670 | chr13:27845621 | ENST00000218981 | - | 2 | 8 | 47_53 | 42 | 243 | Nucleotide binding | NAD or NADP |
Hgene | >DHRS12 | chr13:52373670 | chr13:27845621 | ENST00000280056 | - | 2 | 8 | 47_53 | 42 | 272 | Nucleotide binding | NAD or NADP |
Tgene | RASL11A | chr13:52373670 | chr13:27845621 | ENST00000241463 | + | 0 | 4 | 34_41 | 41 | 243 | Nucleotide binding | GTP |
Tgene | RASL11A | chr13:52373670 | chr13:27845621 | ENST00000241463 | + | 0 | 4 | 17_241 | 41 | 243 | Region | Note=Small GTPase-like |
Top |
FusionGeneSequence for DHRS12_RASL11A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_265aa MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRAMIVRFLTKRFIGDYEPNTGKLYSRLV YVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQ |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_795nt ATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCATGTAAAGACTTTGTC CCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAACTGCCCTTGAAATC GCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGTATTCACGGCTGGTC TATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCCAGGTCGTCGATTCC CTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCATCCGACCCCTTTAT CAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATGCCCGGCAGGTGCAG ACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAGATGTCTGTGATGTG TTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTCGGCCCCGCTCTCCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_DHRS12_ENST00000444610_chr13_52373670_-_RASL11A_ENST00000241463_chr13_27845621_+_1005nt GGGGCGCTCCCGGCATGTCCCTGTACCGCAGCGTCGTGTGGTTCGCCAAGGGGCTGCGCGAGTACACCAAGAGTGGCTATGAATCTGCAT GTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGGCAAAGCAA CTGCCCTTGAAATCGCCAAGCGAGCAATGATCGTGCGCTTCCTGACCAAGAGATTCATTGGAGACTATGAACCGAATACAGGCAAGCTGT ATTCACGGCTGGTCTATGTCGAGGGGGACCAGCTCTCCCTGCAGATCCAGGATACTCCCGGGGGCGTCCAGATCCAAGACAGCCTCCCCC AGGTCGTCGATTCCCTGTCCAAATGCGTGCAGTGGGCCGAGGGTTTTCTGCTGGTCTATTCCATCACAGACTATGACAGCTACTTGTCCA TCCGACCCCTTTATCAGCACATCCGGAAGGTCCACCCTGACTCTAAAGCCCCTGTCATCATCGTGGGCAACAAGGGGGACCTTTTGCATG CCCGGCAGGTGCAGACACAGGACGGTATTCAGCTAGCCAATGAGCTGGGCAGCCTGTTCCTTGAAATTTCCACTAGCGAAAACTACGAAG ATGTCTGTGATGTGTTTCAGCATCTCTGCAAAGAAGTGAGCAAGATGCACGGCCTCAGTGGGGAAAGAAGAAGAGCCTCCATCATCCCTC GGCCCCGCTCTCCCAACATGCAGGACCTGAAGAGACGCTTCAAGCAGGCTCTGTCTCCCAAAGTCAAAGCCCCCTCTGCACTGGGGTGAA CTATCTCAGACAGATGCCTCTCCTTTTTAATACGCATTTGTGCAGCTAAAAGACTGGGCTTCTCGCTTTTTAATCACACATTCAGAGTTT ATTTTTATAAAAAAATTGATTTTCAAGTACATGTGTATTTCTGAAAATTCAAACAGTGATTGCCTAGAAGCTGGATAAAATTTTGTTTTG |
Top |
FusionGenePPI for DHRS12_RASL11A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DHRS12 | H3F3A | RASL11A | ELAVL1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DHRS12_RASL11A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DHRS12_RASL11A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RASL11A | C0014175 | Endometriosis | 1 | CTD_human |