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Fusion gene ID: 9884 |
FusionGeneSummary for DHRS12_LYAR |
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Fusion gene information | Fusion gene name: DHRS12_LYAR | Fusion gene ID: 9884 | Hgene | Tgene | Gene symbol | DHRS12 | LYAR | Gene ID | 79758 | 55646 |
Gene name | dehydrogenase/reductase 12 | Ly1 antibody reactive | |
Synonyms | SDR40C1 | ZC2HC2|ZLYAR | |
Cytomap | 13q14.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1 | cell growth-regulating nucleolar proteinLy1 antibody reactive homolog | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | A0PJE2 | Q9NX58 | |
Ensembl transtripts involved in fusion gene | ENST00000444610, ENST00000218981, ENST00000280056, ENST00000490949, | ENST00000343470, ENST00000452476, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 5 X 4=120 |
# samples | 4 | 7 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DHRS12 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF800135 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000444610 | ENST00000343470 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000444610 | ENST00000452476 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000218981 | ENST00000343470 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000218981 | ENST00000452476 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000280056 | ENST00000343470 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000280056 | ENST00000452476 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000490949 | ENST00000343470 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
intron-3CDS | ENST00000490949 | ENST00000452476 | DHRS12 | chr13 | 52358796 | + | LYAR | chr4 | 4283592 | + |
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FusionProtFeatures for DHRS12_LYAR |
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Hgene | Tgene |
DHRS12 | LYAR |
Putative oxidoreductase. {ECO:0000250}. | Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHRS12_LYAR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHRS12_LYAR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHRS12_LYAR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHRS12_LYAR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |