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Fusion gene ID: 9865 |
FusionGeneSummary for DHCR24_TADA2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHCR24_TADA2B | Fusion gene ID: 9865 | Hgene | Tgene | Gene symbol | DHCR24 | TADA2B | Gene ID | 1718 | 93624 |
| Gene name | 24-dehydrocholesterol reductase | transcriptional adaptor 2B | |
| Synonyms | DCE|Nbla03646|SELADIN1|seladin-1 | ADA2(beta)|ADA2B | |
| Cytomap | 1p32.3 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | delta(24)-sterol reductase3 beta-hydroxysterol delta 24-reductasedesmosterol-to-cholesterol enzymediminuto/dwarf1 homologseladin 1selective AD indicator 1 | transcriptional adapter 2-betaADA2-betaADA2-like protein betatranscriptional adaptor 2 (ADA2 homolog, yeast)-beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15392 | Q86TJ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000371269, ENST00000537443, ENST00000535035, | ENST00000310074, ENST00000512388, ENST00000515646, | |
| Fusion gene scores | * DoF score | 17 X 10 X 7=1190 | 2 X 2 X 2=8 |
| # samples | 24 | 2 | |
| ** MAII score | log2(24/1190*10)=-2.30985526258679 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DHCR24 [Title/Abstract] AND TADA2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHCR24 | GO:0043066 | negative regulation of apoptotic process | 15688385 |
| Hgene | DHCR24 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11007892 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-NJ-A4YF-01A | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371269 | ENST00000310074 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| Frame-shift | ENST00000371269 | ENST00000512388 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| 5CDS-5UTR | ENST00000371269 | ENST00000515646 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| intron-3CDS | ENST00000537443 | ENST00000310074 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| intron-3CDS | ENST00000537443 | ENST00000512388 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| intron-5UTR | ENST00000537443 | ENST00000515646 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| In-frame | ENST00000535035 | ENST00000310074 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| Frame-shift | ENST00000535035 | ENST00000512388 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
| 5CDS-5UTR | ENST00000535035 | ENST00000515646 | DHCR24 | chr1 | 55330976 | - | TADA2B | chr4 | 7055789 | + |
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FusionProtFeatures for DHCR24_TADA2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHCR24 | TADA2B |
| Catalyzes the reduction of the Delta-24 double bond ofsterol intermediates. Protects cells from oxidative stress byreducing caspase 3 activity during apoptosis induced by oxidativestress. Also protects against amyloid-beta peptide-inducedapoptosis. {ECO:0000269|PubMed:11007892,ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:22010141}. | Coactivates PAX5-dependent transcription together witheither SMARCA4 or GCN5L2. {ECO:0000269|PubMed:12972612}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHCR24 | chr1:55330976 | chr4:7055789 | ENST00000371269 | - | 6 | 9 | 58_234 | 340 | 517 | Domain | FAD-binding PCMH-type |
| Hgene | DHCR24 | chr1:55330976 | chr4:7055789 | ENST00000371269 | - | 6 | 9 | 163_175 | 340 | 517 | Nucleotide binding | FAD |
| Hgene | DHCR24 | chr1:55330976 | chr4:7055789 | ENST00000371269 | - | 6 | 9 | 23_31 | 340 | 517 | Topological domain | Lumenal |
| Hgene | DHCR24 | chr1:55330976 | chr4:7055789 | ENST00000371269 | - | 6 | 9 | 32_52 | 340 | 517 | Transmembrane | Helical |
| Tgene | >TADA2B | chr1:55330976 | chr4:7055789 | ENST00000512388 | + | 0 | 2 | 65_118 | 15 | 346 | Domain | SANT |
| Tgene | >TADA2B | chr1:55330976 | chr4:7055789 | ENST00000515646 | + | 0 | 1 | 65_118 | -415 | 329 | Domain | SANT |
| Tgene | >TADA2B | chr1:55330976 | chr4:7055789 | ENST00000515646 | + | 0 | 1 | 3_49 | -415 | 329 | Zinc finger | ZZ-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DHCR24 | chr1:55330976 | chr4:7055789 | ENST00000371269 | - | 6 | 9 | 53_516 | 340 | 517 | Topological domain | Cytoplasmic |
| Tgene | TADA2B | chr1:55330976 | chr4:7055789 | ENST00000310074 | + | 0 | 2 | 65_118 | 90 | 421 | Domain | SANT |
| Tgene | TADA2B | chr1:55330976 | chr4:7055789 | ENST00000310074 | + | 0 | 2 | 3_49 | 90 | 421 | Zinc finger | ZZ-type |
| Tgene | TADA2B | chr1:55330976 | chr4:7055789 | ENST00000512388 | + | 0 | 2 | 3_49 | 15 | 346 | Zinc finger | ZZ-type |
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FusionGeneSequence for DHCR24_TADA2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DHCR24_ENST00000371269_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_671aa MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFM CTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKY GLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGL LYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQEDMAAHVGASRTPQEVMEHY VSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIE LKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRE LQRYRRNGITKMEESAEYEAARHKREKRKENKNLAGSKRGKEDGKDSEFAAIENLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDH >In-frame_DHCR24_ENST00000535035_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_630aa MGAGEQNRQSAHCVQGICGYLEGDEEGEEGEVRSTQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIV RVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTL GFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENY LKTNREGLEYIPLRHYYHRHTRSIFWELQEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPL PPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKE KALKRKITKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKREKRKENKNLAGSKRGK EDGKDSEFAAIENLPGFELLSDREKVLCSSLNLSPARYVTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWISRDASX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DHCR24_ENST00000371269_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_2013nt ATGGAGCCCGCCGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTGTGGGTGCGCCTGAAGGGGCTGGAGTTCGTGCTCATCCACCAG CGCTGGGTGTTCGTGTGCCTCTTCCTCCTGCCGCTCTCGCTTATCTTCGATATCTACTACTACGTGCGCGCCTGGGTGGTGTTCAAGCTC AGCAGCGCTCCGCGCCTGCACGAGCAGCGCGTGCGGGACATCCAGAAGCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAGACCTTCATG TGCACGGGGCGCCCTGGCTGGCTCACTGTCTCACTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGAC ATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGGAGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACCTCCATTGGC TGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTAC GGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAACTCAGACCTG TTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTG CGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTG CTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTAC AAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGC CACACGCGCAGCATCTTCTGGGAGCTCCAGGAAGATATGGCTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATGGAGCATTAC GTGAGCATGTACATCCACGGGAACCTGGGGAAGGCCTGCATCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGTCCCAGCGGA GGCCCCCTCTCACCCAGCCTCACCACCCCGCTGCCCCCGCTGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATGCCGCTGCGG GATGATTACGAGATCGAGTATGACCAGGATGCCGAGACGCTCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTGGAGATCGAG CTGAAGCGCGCCCACGTGGACATGTACGTGCGGAAGCTGAAAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAATCTGGTGCCA GCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAAAAGGCGCTGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTGAAGCTGAGG CCGCTGTACCAGTTCATGTCATGCAAGGAGTTTGATGACCTTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAGATCCGAGAA CTGCAGCGGTACCGGCGAAACGGGATCACCAAGATGGAAGAGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAGAGGAAGGAG AACAAAAACCTAGCCGGCTCCAAACGGGGAAAGGAGGACGGCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGCTTCGAGCTC CTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCTTTAAACTTGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATTAAAGACCAC CTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGCCGCCTTCCTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAATTTCCTCACA >In-frame_DHCR24_ENST00000535035_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_1890nt ATGGGGGCGGGGGAACAGAACAGGCAAAGTGCCCACTGTGTGCAGGGCATATGCGGGTACCTGGAGGGAGATGAAGAAGGGGAAGAGGGG GAGGTGCGAAGCACTCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAGACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTCTCA CTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGACATTCTGGAAGTGGACACCAAGAAACAGATTGTC CGTGTGGAGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGAC CTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAG CTGGTCCTGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTG GGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATC TGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACA GGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTAT CTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAA GATATGGCTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATGGAGCATTACGTGAGCATGTACATCCACGGGAACCTGGGGAAG GCCTGCATCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGTCCCAGCGGAGGCCCCCTCTCACCCAGCCTCACCACCCCGCTG CCCCCGCTGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATGCCGCTGCGGGATGATTACGAGATCGAGTATGACCAGGATGCC GAGACGCTCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTGGAGATCGAGCTGAAGCGCGCCCACGTGGACATGTACGTGCGG AAGCTGAAAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAATCTGGTGCCAGCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAA AAGGCGCTGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTGAAGCTGAGGCCGCTGTACCAGTTCATGTCATGCAAGGAGTTT GATGACCTTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAGATCCGAGAACTGCAGCGGTACCGGCGAAACGGGATCACCAAG ATGGAAGAGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAGAGGAAGGAGAACAAAAACCTAGCCGGCTCCAAACGGGGAAAG GAGGACGGCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGCTTCGAGCTCCTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCT TTAAACTTGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATTAAAGACCACCTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGC CGCCTTCCTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAATTTCCTCACAGAAAGCGGCTGGATCTCCAGGGACGCGTCTTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DHCR24_ENST00000371269_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_5010nt CCCGGGCTGTGGGCTACAGGCGCAGAGCGGGCCAGGCGCGGAGCTGGCGGCAGTGACAGGAGGCGCGAACCCGCAGCGCTTACCGCGCGG CGCCGCACCATGGAGCCCGCCGTGTCGCTGGCCGTGTGCGCGCTGCTCTTCCTGCTGTGGGTGCGCCTGAAGGGGCTGGAGTTCGTGCTC ATCCACCAGCGCTGGGTGTTCGTGTGCCTCTTCCTCCTGCCGCTCTCGCTTATCTTCGATATCTACTACTACGTGCGCGCCTGGGTGGTG TTCAAGCTCAGCAGCGCTCCGCGCCTGCACGAGCAGCGCGTGCGGGACATCCAGAAGCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAG ACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTCTCACTACGTGTCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAAC CTGATGGACATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGGAGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACC TCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCC CACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAAC TCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTAC GTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTG GAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGC AATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTAC TACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAAGATATGGCTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATG GAGCATTACGTGAGCATGTACATCCACGGGAACCTGGGGAAGGCCTGCATCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGT CCCAGCGGAGGCCCCCTCTCACCCAGCCTCACCACCCCGCTGCCCCCGCTGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATG CCGCTGCGGGATGATTACGAGATCGAGTATGACCAGGATGCCGAGACGCTCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTG GAGATCGAGCTGAAGCGCGCCCACGTGGACATGTACGTGCGGAAGCTGAAAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAAT CTGGTGCCAGCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAAAAGGCGCTGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTG AAGCTGAGGCCGCTGTACCAGTTCATGTCATGCAAGGAGTTTGATGACCTTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAG ATCCGAGAACTGCAGCGGTACCGGCGAAACGGGATCACCAAGATGGAAGAGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAG AGGAAGGAGAACAAAAACCTAGCCGGCTCCAAACGGGGAAAGGAGGACGGCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGC TTCGAGCTCCTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCTTTAAACTTGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATT AAAGACCACCTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGCCGCCTTCCTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAAT TTCCTCACAGAAAGCGGCTGGATCTCCAGGGACGCGTCTTGAAGCTGAGACGCTTTGAAAGCCAGGGTGATGCTCAGACAGTGTGCCAGC CAAAATGACTTGGGGGAGGGGAGCCGCTTCCCCACTGTTGCTCTTTTTTAAACAAATTGAGTTCCTTTTTTTAAGATAGAAATTCTTTTC ATGGTCCTCTGAAAGAAGCAATAGTAACAATCTTATATTGGATCATGGGGGAAGCAAATGTGTGTATTTTAAGTGAGTTCCTGCGAGTCA TACACTGCGATGATGCTCCGCCTTTACCCGTTCAGTTGGGAGCTTATTGTGAGATTGGATCATTTCCTTTTGAGTGTTCTTCTCTTTGGT ACAAAAGCTATTGTGGGTGACAGGAGCAGTGTTTTCCTGCTGGACCCGCAAGCCACCAGCTATTTCCTGGTGACACAAGCTCTTCTCAGG CGGGGCTGCCTGCAGGCTCCCGTTTTCTGAGCCCACGCTGCCCACAGCTGACCCCAGCGCAGCCCCGGGCACGCGGCACTTTACATGGGG GCAGCTTGGGCCCAGACTCCTCCGCTGTGTAGCAGATGAGGAAAATCAGGCCAGAGGACAACAGGCTGGCGTTTTGTTGGGAACTGAAGA GGAATCTGTTGAACACAGCGACCAGATGACCTTCCATTTCACCGGCGGCAGCAGTTTCAGCGTGCAGTTCCCAAACCCCAAAGCTGACCC TGCGCCCCATTTGAATACGGCCAGAGCCTGCTGGTTCACTTTGGGTAGAGCCGTGCCTCTTGGGCAGGCTCCCATAGTGACCACGTCCCC ACGAATGGGAAAGCACGTTAGTGGGAGGGACGTAGGACACGTGTGGACCGCCAGGCCCTCTCAGTCCATTTTCCGGGGCTGCTCGGTGCT GCTGTTAAGACGTGAGTGCATTTCACTTGGAAGAACCCATTGTACAAAGTTCAAGGCTAAGAGTTCTGAATTCTGGCGTCAGCTTCCTCA GGATTTTCTTCAGTTGCAAGTACCTTTCCACTGAAAATATGAGCATGCCCGCCTGGCTAGTAGGCATCTGTAAGAGTGTCGCCAGGCCCG CGCCAGCTGAGGCCTCAGACTAGCCAGGCAAGAGCCGTCTGACCAGTTGGCTGGCGGTGGTTCTGGTGGAGCACGAGGGAGCCCGGGTGG TGCCCTGAGCCTCGAGCTGCTCTCTGTCACTGTCTTGAATCAGACTCAGAAATGGCTTCTTCCCAGCCCTGCCTACAAGTTTTTCTCTGG GGTCCTCTTTCAAGGATGTCCACGGTACCTTCCTCCTGAAACTTGAGGAAGTCTTTTGTCTTCCAGCTGCTCAGGGTTCTCTGGTCCAAG ACCCTGCTTTAAAGAGAGTCTTTGGCGTGCTCAGACTCCAGCGCTCCGTTCTTCAAGGAGGTTGACTTGCCTCTCGGGCCCCGTAGGTAC CAAGAGACTGTTTACCTCCCAGAATGTTTGGGCTTGAAGTTACATTAAAGTGAAGTTATTTGAAAGAAAGAAAACCTCATCATTTCTAAG GATGACTTAATTACTGTGCCTTTTCCTTTCTTTTTACACATCCTACTGTCCCTTAGGGTAAAATTTTCAGCATTAAATAAAACATTTCAA ATATATTGTATATGGCTTTAGTTGTAAACTATACTGCATGCTGACAGAGAAGCGCTCTTTTAGCTAAGCCCAGAACTTCTCTTTTGACAA TAAAGTACTGAGCAGTGGTATCATGAGGGCCACCTCCACATTGTCCCCTGCAGAATAAATGCGGATGACAGAAAGCTTATGCTGTCTACC ACTGAACAGTGATGGAGATGGTGCTAAGTTTTTACAGTTGTCTTAGCCCCAGTGGTTCTCAAGGTGGGGCTCCTGGCCCAGCAGCAGCAA CTTGTTTGTTAGAATGCAGACGCGCAGGCCCCACCTGGCCTCCTGAATCAAAATGGTGTGCGGCAGGGTGCAGCGAGCTGTTTTCACGAG GCCTCCAGGTGACTGGATGTAAGCTTGCTTGAGAACTATGGGTTTTAGCTATTCTGGTGTCTCCCTGATTTTCTACAGCGCCAGGATCCT AGTTTGGTGAGGTTTTAAATTTAATCTTATTTTTATATAAAATGATTGCCAGACGTACTATATTAAGCTTGAAGAAGCAGAAGATCCCTG TTAATGTGTATGGCCCAGGCCAAGAGCTGTCAAATGAAAAACTTTGTGCTGAAGCAGGTTTTTAGTATGTATATCTTTTTGATGGTATGA AGAATTTATTTAGGCTTGACTGTTTTAAAACACCATAATGAATGTATAATTAATTTATGTTAAAGTATTAACCCTTTGTCACAAAGGAAT GGTAATGTGATTGGCTGCCTGTTAGCCCATCGACTATTCCCGTCACGGTAGTCCTTACCTCTGTCGGCAGCTCAGAGCCTCCACATTTTT ATATTTAATTCTCATGATAAATTAGCCACCATAATCCCATGGAATTAGGTCTTGTTAAAATCTAGTCCGGGCGCAGTGGCTCACGCCTGT AATCCCAGCACTTTGGGAGGCCAAGGCGGGCTGATCACGAGGTCAAGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCTGTCTCTA CTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTAGGAGAATTGCTTGAACCTG GGAGGCGGAGGTTGCGGTGAGCTGAGATCACGCCACTACACTCCAGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAAATCTAAGCAA ACTATCTTTGAGTCAAAAAAAGTTGGATAACTCATCTATATTTGAAATAATGCTGTCTGAATGGCCAACATCCCAAGAATGTATTAAAAA >In-frame_DHCR24_ENST00000535035_chr1_55330976_-_TADA2B_ENST00000310074_chr4_7055789_+_4871nt AGCTGCGGTGCGGGGGCGGCCAGGACTTCCTGGGGGGGTGGGGAGCTGGCGTTGGAGAGGGGTTGGAACGAAACAAAAATGTGATGGGGG CGGGGGAACAGAACAGGCAAAGTGCCCACTGTGTGCAGGGCATATGCGGGTACCTGGAGGGAGATGAAGAAGGGGAAGAGGGGGAGGTGC GAAGCACTCAGGTGCGGGAATGGAAGGAGCAGGGTAGCAAGACCTTCATGTGCACGGGGCGCCCTGGCTGGCTCACTGTCTCACTACGTG TCGGGAAGTACAAGAAGACACACAAAAACATCATGATCAACCTGATGGACATTCTGGAAGTGGACACCAAGAAACAGATTGTCCGTGTGG AGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAG TGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCC TGGCTGATGGCAGCTTTGTGCGATGCACTCCGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCC TGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCA AGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCA TGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGA CAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAAGATATGG CTGCCCACGTTGGTGCTTCCCGGACTCCCCAAGAGGTGATGGAGCATTACGTGAGCATGTACATCCACGGGAACCTGGGGAAGGCCTGCA TCCCCGACACCATCCCCAACCGCGTGACAGACCACACCTGTCCCAGCGGAGGCCCCCTCTCACCCAGCCTCACCACCCCGCTGCCCCCGC TGGACATCTCTGTGGCTGAGCAGCAGCAGCTGGGCTACATGCCGCTGCGGGATGATTACGAGATCGAGTATGACCAGGATGCCGAGACGC TCATCAGCGGGCTCTCTGTCAACTATGATGACGACGACGTGGAGATCGAGCTGAAGCGCGCCCACGTGGACATGTACGTGCGGAAGCTGA AAGAGAGACAGCGGCGGAAGAACATCGCCCGTGACTACAATCTGGTGCCAGCCTTCCTGGGGAAGGACAAGAAGGAGAAGGAAAAGGCGC TGAAGCGCAAGATCACCAAGGAGGAGAAGGAGCTGCGCCTGAAGCTGAGGCCGCTGTACCAGTTCATGTCATGCAAGGAGTTTGATGACC TTTTTGAAAACATGCACAAAGAAAAAATGCTCCGGGCCAAGATCCGAGAACTGCAGCGGTACCGGCGAAACGGGATCACCAAGATGGAAG AGTCGGCAGAGTACGAGGCAGCGCGGCATAAACGGGAGAAGAGGAAGGAGAACAAAAACCTAGCCGGCTCCAAACGGGGAAAGGAGGACG GCAAAGACAGCGAGTTCGCCGCCATTGAGAACCTTCCAGGCTTCGAGCTCCTGTCAGATCGCGAGAAGGTGCTCTGCAGCTCTTTAAACT TGAGTCCAGCCCGCTACGTGACTGTGAAGACTATTATAATTAAAGACCACCTCCAGAAGCGGCAAGGAATCCCCTCCAAAAGCCGCCTTC CTAGCTACCTGGACAAAGTCCTAAAGAAAAGGATTTTGAATTTCCTCACAGAAAGCGGCTGGATCTCCAGGGACGCGTCTTGAAGCTGAG ACGCTTTGAAAGCCAGGGTGATGCTCAGACAGTGTGCCAGCCAAAATGACTTGGGGGAGGGGAGCCGCTTCCCCACTGTTGCTCTTTTTT AAACAAATTGAGTTCCTTTTTTTAAGATAGAAATTCTTTTCATGGTCCTCTGAAAGAAGCAATAGTAACAATCTTATATTGGATCATGGG GGAAGCAAATGTGTGTATTTTAAGTGAGTTCCTGCGAGTCATACACTGCGATGATGCTCCGCCTTTACCCGTTCAGTTGGGAGCTTATTG TGAGATTGGATCATTTCCTTTTGAGTGTTCTTCTCTTTGGTACAAAAGCTATTGTGGGTGACAGGAGCAGTGTTTTCCTGCTGGACCCGC AAGCCACCAGCTATTTCCTGGTGACACAAGCTCTTCTCAGGCGGGGCTGCCTGCAGGCTCCCGTTTTCTGAGCCCACGCTGCCCACAGCT GACCCCAGCGCAGCCCCGGGCACGCGGCACTTTACATGGGGGCAGCTTGGGCCCAGACTCCTCCGCTGTGTAGCAGATGAGGAAAATCAG GCCAGAGGACAACAGGCTGGCGTTTTGTTGGGAACTGAAGAGGAATCTGTTGAACACAGCGACCAGATGACCTTCCATTTCACCGGCGGC AGCAGTTTCAGCGTGCAGTTCCCAAACCCCAAAGCTGACCCTGCGCCCCATTTGAATACGGCCAGAGCCTGCTGGTTCACTTTGGGTAGA GCCGTGCCTCTTGGGCAGGCTCCCATAGTGACCACGTCCCCACGAATGGGAAAGCACGTTAGTGGGAGGGACGTAGGACACGTGTGGACC GCCAGGCCCTCTCAGTCCATTTTCCGGGGCTGCTCGGTGCTGCTGTTAAGACGTGAGTGCATTTCACTTGGAAGAACCCATTGTACAAAG TTCAAGGCTAAGAGTTCTGAATTCTGGCGTCAGCTTCCTCAGGATTTTCTTCAGTTGCAAGTACCTTTCCACTGAAAATATGAGCATGCC CGCCTGGCTAGTAGGCATCTGTAAGAGTGTCGCCAGGCCCGCGCCAGCTGAGGCCTCAGACTAGCCAGGCAAGAGCCGTCTGACCAGTTG GCTGGCGGTGGTTCTGGTGGAGCACGAGGGAGCCCGGGTGGTGCCCTGAGCCTCGAGCTGCTCTCTGTCACTGTCTTGAATCAGACTCAG AAATGGCTTCTTCCCAGCCCTGCCTACAAGTTTTTCTCTGGGGTCCTCTTTCAAGGATGTCCACGGTACCTTCCTCCTGAAACTTGAGGA AGTCTTTTGTCTTCCAGCTGCTCAGGGTTCTCTGGTCCAAGACCCTGCTTTAAAGAGAGTCTTTGGCGTGCTCAGACTCCAGCGCTCCGT TCTTCAAGGAGGTTGACTTGCCTCTCGGGCCCCGTAGGTACCAAGAGACTGTTTACCTCCCAGAATGTTTGGGCTTGAAGTTACATTAAA GTGAAGTTATTTGAAAGAAAGAAAACCTCATCATTTCTAAGGATGACTTAATTACTGTGCCTTTTCCTTTCTTTTTACACATCCTACTGT CCCTTAGGGTAAAATTTTCAGCATTAAATAAAACATTTCAAATATATTGTATATGGCTTTAGTTGTAAACTATACTGCATGCTGACAGAG AAGCGCTCTTTTAGCTAAGCCCAGAACTTCTCTTTTGACAATAAAGTACTGAGCAGTGGTATCATGAGGGCCACCTCCACATTGTCCCCT GCAGAATAAATGCGGATGACAGAAAGCTTATGCTGTCTACCACTGAACAGTGATGGAGATGGTGCTAAGTTTTTACAGTTGTCTTAGCCC CAGTGGTTCTCAAGGTGGGGCTCCTGGCCCAGCAGCAGCAACTTGTTTGTTAGAATGCAGACGCGCAGGCCCCACCTGGCCTCCTGAATC AAAATGGTGTGCGGCAGGGTGCAGCGAGCTGTTTTCACGAGGCCTCCAGGTGACTGGATGTAAGCTTGCTTGAGAACTATGGGTTTTAGC TATTCTGGTGTCTCCCTGATTTTCTACAGCGCCAGGATCCTAGTTTGGTGAGGTTTTAAATTTAATCTTATTTTTATATAAAATGATTGC CAGACGTACTATATTAAGCTTGAAGAAGCAGAAGATCCCTGTTAATGTGTATGGCCCAGGCCAAGAGCTGTCAAATGAAAAACTTTGTGC TGAAGCAGGTTTTTAGTATGTATATCTTTTTGATGGTATGAAGAATTTATTTAGGCTTGACTGTTTTAAAACACCATAATGAATGTATAA TTAATTTATGTTAAAGTATTAACCCTTTGTCACAAAGGAATGGTAATGTGATTGGCTGCCTGTTAGCCCATCGACTATTCCCGTCACGGT AGTCCTTACCTCTGTCGGCAGCTCAGAGCCTCCACATTTTTATATTTAATTCTCATGATAAATTAGCCACCATAATCCCATGGAATTAGG TCTTGTTAAAATCTAGTCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCTGATCACGAGGTCAAGAG ATCGAGACCATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCC AGCTACTTGGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCGGTGAGCTGAGATCACGCCACTACACTCCAGCCT GGTGACAGAGCAAGACTCCATCTCAAAAAAAATCTAAGCAAACTATCTTTGAGTCAAAAAAAGTTGGATAACTCATCTATATTTGAAATA ATGCTGTCTGAATGGCCAACATCCCAAGAATGTATTAAAAACAGCAACCCTGCCTACCGTTTTGATGACCTTTTTCCATATTAAACAAGT |
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FusionGenePPI for DHCR24_TADA2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHCR24 | TP53, UBL4A, EGFR, IKBKB, ACTA2, ATP12A, FUNDC2, REEP5, ERAP1, HRAS, LUZP1, GBA, SNCA, CKAP5, NANOG, POU5F1, COQ9, NDUFA4, CISD3, ATP6V0D1, PTPN1, PTPN5 | TADA2B | USP22, SREBF1, SUPT3H, HECW2, CCDC101, TAF5L, TADA1, SUPT20H, TERF2IP, TRRAP, TADA3, EPN1, TAF9B, TAF9, TAF10, TERF2, SIRT1, TAF12, SUPT7L, TAF6L, SF3B5, ATXN7L3, GGPS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHCR24_TADA2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHCR24_TADA2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DHCR24 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Hgene | DHCR24 | C0034362 | Q Fever | 1 | CTD_human |
| Hgene | DHCR24 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Hgene | DHCR24 | C1865596 | Desmosterolosis | 1 | CTD_human;ORPHANET;UNIPROT |
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