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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9842

FusionGeneSummary for DGKQ_POLN

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKQ_POLN
Fusion gene ID: 9842
HgeneTgene
Gene symbol

DGKQ

POLN

Gene ID

1609

353497

Gene namediacylglycerol kinase thetaDNA polymerase nu
SynonymsDAGK|DAGK4|DAGK7POL4P
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase thetaDAG kinase thetaDGK-thetadiacylglycerol kinase, theta 110kDadiglyceride kinase thetatestis tissue sperm-binding protein Li 38aDNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu
Modification date2018051920180523
UniProtAcc

P52824

Q7Z5Q5

Ensembl transtripts involved in fusion geneENST00000273814, ENST00000502309, 
ENST00000382865, ENST00000511885, 
ENST00000515357, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 7 X 9=756
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGKQ [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKQ

GO:0006357

regulation of transcription by RNA polymerase II

17664281

HgeneDGKQ

GO:0006654

phosphatidic acid biosynthetic process

22732145

HgeneDGKQ

GO:0008277

regulation of G-protein coupled receptor protein signaling pathway

22732145

HgeneDGKQ

GO:0010801

negative regulation of peptidyl-threonine phosphorylation

22732145

HgeneDGKQ

GO:0019933

cAMP-mediated signaling

17664281

HgeneDGKQ

GO:0033198

response to ATP

15632189

HgeneDGKQ

GO:0046339

diacylglycerol metabolic process

11309392|22627129

HgeneDGKQ

GO:0046486

glycerolipid metabolic process

22627129

HgeneDGKQ

GO:0046834

lipid phosphorylation

11309392|22627129

HgeneDGKQ

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

22732145

HgeneDGKQ

GO:0051591

response to cAMP

23610160

HgeneDGKQ

GO:0070493

thrombin-activated receptor signaling pathway

15632189

HgeneDGKQ

GO:0070528

protein kinase C signaling

15632189

TgenePOLN

GO:0019985

translesion synthesis

20102227


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A113-01ADGKQchr4

980594

-POLNchr4

2097660

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000273814ENST00000382865DGKQchr4

980594

-POLNchr4

2097660

-
intron-3CDSENST00000273814ENST00000511885DGKQchr4

980594

-POLNchr4

2097660

-
intron-intronENST00000273814ENST00000515357DGKQchr4

980594

-POLNchr4

2097660

-
intron-3CDSENST00000502309ENST00000382865DGKQchr4

980594

-POLNchr4

2097660

-
intron-3CDSENST00000502309ENST00000511885DGKQchr4

980594

-POLNchr4

2097660

-
intron-intronENST00000502309ENST00000515357DGKQchr4

980594

-POLNchr4

2097660

-

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FusionProtFeatures for DGKQ_POLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKQ

P52824

POLN

Q7Z5Q5

Phosphorylates diacylglycerol (DAG) to generatephosphatidic acid (PA). May regulate the activity of proteinkinase C by controlling the balance between these two signalinglipids. Activated in the nucleus in response to alpha-thrombin andnerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic genetranscription by delivering PA as ligand for NR5A1. Actssynergistically with NR5A1 on CYP17 transcriptional activity.{ECO:0000250, ECO:0000269|PubMed:17664281}. DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DGKQ_POLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DGKQ_POLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DGKQRHOA, KDM5B, EHD1, CCBL1, EHD4, EZR, EIF4H, SHMT2, HAVCR2POLNATR, FANCD2, POLDIP2, FANCA, FANCG, PCNA, FANCI, RAD51, HELQ, RAD18, BRCA1, BARD1, PALB2, BRCA2, BRIP1, RBBP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DGKQ_POLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DGKQ_POLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDGKQC1527336Sjogren's Syndrome1CTD_human