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Fusion gene ID: 9830 |
FusionGeneSummary for DGKD_SPP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DGKD_SPP2 | Fusion gene ID: 9830 | Hgene | Tgene | Gene symbol | DGKD | SPP2 | Gene ID | 8527 | 130367 |
| Gene name | diacylglycerol kinase delta | sphingosine-1-phosphate phosphatase 2 | |
| Synonyms | DGKdelta|dgkd-2 | SPP2|SPPase2 | |
| Cytomap | 2q37.1 | 2q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | diacylglycerol kinase deltaDAG kinase deltaDGK-deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta | sphingosine-1-phosphate phosphatase 2sphingosine 1-phosphate phosphohydrolase 2sphingosine-1-phosphatase 2sphingosine-1-phosphate phosphotase 2 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q16760 | Q13103 | |
| Ensembl transtripts involved in fusion gene | ENST00000264057, ENST00000409813, ENST00000489613, | ENST00000373368, ENST00000168148, ENST00000492481, | |
| Fusion gene scores | * DoF score | 7 X 3 X 9=189 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DGKD [Title/Abstract] AND SPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DGKD | GO:0010033 | response to organic substance | 12200442 |
| Hgene | DGKD | GO:0051260 | protein homooligomerization | 12200442 |
| Tgene | SPP2 | GO:0006670 | sphingosine metabolic process | 12411432 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-28-2499-01A | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264057 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000264057 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| 5CDS-intron | ENST00000264057 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000409813 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| In-frame | ENST00000409813 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| 5CDS-intron | ENST00000409813 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-3CDS | ENST00000489613 | ENST00000373368 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-3CDS | ENST00000489613 | ENST00000168148 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
| intron-intron | ENST00000489613 | ENST00000492481 | DGKD | chr2 | 234299129 | + | SPP2 | chr2 | 234967480 | + |
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FusionProtFeatures for DGKD_SPP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DGKD | SPP2 |
| May function as signaling molecule.{ECO:0000269|PubMed:17880279}. Isoform 2 may be involved in cell growth andtumorigenesis. Involved in clathrin-dependent endocytosis.{ECO:0000269|PubMed:17880279}. | Could coordinate an aspect of bone turnover.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 8_36 | 116 | 1215 | Compositional bias | Note=Pro-rich |
| Hgene | DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 8_36 | 72 | 1171 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 1145_1208 | 116 | 1215 | Domain | SAM |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 317_451 | 116 | 1215 | Domain | DAGKc |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 53_146 | 116 | 1215 | Domain | PH |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 1145_1208 | 72 | 1171 | Domain | SAM |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 317_451 | 72 | 1171 | Domain | DAGKc |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 53_146 | 72 | 1171 | Domain | PH |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 163_213 | 116 | 1215 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000264057 | + | 3 | 30 | 235_286 | 116 | 1215 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 163_213 | 72 | 1171 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Hgene | >DGKD | chr2:234299129 | chr2:234967480 | ENST00000409813 | + | 2 | 29 | 235_286 | 72 | 1171 | Zinc finger | Phorbol-ester/DAG-type 2 |
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FusionGeneSequence for DGKD_SPP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_258aa MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS IIFDEVDLTDASVAESSTKNVNNSFTVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARC >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_258aa MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS IIFDEVDLTDASVAESSTKNVNNSFTVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARC >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_214aa MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVEVLDENNLVMNLEFSIR ETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQF >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_214aa MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVEVLDENNLVMNLEFSIR ETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_774nt ATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGACAGCGAGCCCGAG GCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAAGAGGGGATGCTG ACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCA ATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTA GATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATGCAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCC TTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGC AGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGGGGACATGTTGGGATCTCATAAATGGAGAAACAATTAT CTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTCACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAAC >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_774nt ATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGACAGCGAGCCCGAG GCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAAGAGGGGATGCTG ACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCA ATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTA GATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATGCAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCC TTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGC AGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGGGGACATGTTGGGATCTCATAAATGGAGAAACAATTAT CTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTCACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAAC >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_642nt ATGAATATGTTTCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATAC TTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCT GAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGG GAGACTACATGCAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGC ACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAG ATGATTTTTGGGGACATGTTGGGATCTCATAAATGGAGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTT TATGATCGGTCACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACT >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_642nt ATGAATATGTTTCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATAC TTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCT GAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGG GAGACTACATGCAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGC ACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAG ATGATTTTTGGGGACATGTTGGGATCTCATAAATGGAGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTT TATGATCGGTCACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_902nt TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG GTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATGCAGGAAGGATTCTGGAGAAGATCCC GCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTG CATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGGGGACATGTTGGGATCTCATAAATGG AGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTCACTTGGGATCATGAGAAGGGTATTG CCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACTGACTTTGAGTAACGGCCTTGAGCAAAATGCAATGGA AGGAAGAAAAGTTCCAACAAAGAATGATTTTGTGAATTCTGTGATTTTTCTTCTGATCAGTTTCAATCTGTAATAAATGCCTTATTTTTC >In-frame_DGKD_ENST00000264057_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_1086nt TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG GTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATGCAGGAAGGATTCTGGAGAAGATCCC GCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGTATCTGCCCAGCAGGTGCAGGGCGTG CATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGGGGACATGTTGGGATCTCATAAATGG AGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTCACTTGGGATCATGAGAAGGGTATTG CCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACTGACTTTGAGTAACGGCCTTGAGGTGTCCCTCGCCCT TTTGGTTTGTTCAAGGAGCTGCTGCTTTGCATAGCTGCTCTAGTGTCTGGTATCATCGGATCTGGTTTTGAATAATTCCCAGGAGTCCTG GGTCCCTGGCCTCCAAAGCTGGAATGTGAACGCATGCCACGGTGGTCTGACCCTCACACTCCTTTTCTCTTAACAGCAAAATGCAATGGA AGGAAGAAAAGTTCCAACAAAGAATGATTTTGTGAATTCTGTGATTTTTCTTCTGATCAGTTTCAATCTGTAATAAATGCCTTATTTTTC >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000373368_chr2_234967480_+_837nt AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC CAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATG CAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGT ATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGG GGACATGTTGGGATCTCATAAATGGAGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTC ACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACTGACTTTGAGTA ACGGCCTTGAGCAAAATGCAATGGAAGGAAGAAAAGTTCCAACAAAGAATGATTTTGTGAATTCTGTGATTTTTCTTCTGATCAGTTTCA >In-frame_DGKD_ENST00000409813_chr2_234299129_+_SPP2_ENST00000168148_chr2_234967480_+_1021nt AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC CAAAAACGTCAACAACAGTTTTACGGTTGAGGTCCTAGATGAGAACAACTTGGTCATGAATTTAGAGTTCAGCATCCGGGAGACTACATG CAGGAAGGATTCTGGAGAAGATCCCGCTACATGTGCCTTCCAGAGGGACTACTATGTGTCCACAGCTGTTTGCAGAAGCACCGTGAAGGT ATCTGCCCAGCAGGTGCAGGGCGTGCATGCTCGCTGCAGCTGGTCCTCCTCCACGTCTGAGTCTTACAGCAGCGAAGAGATGATTTTTGG GGACATGTTGGGATCTCATAAATGGAGAAACAATTATCTATTTGGTCTCATTTCAGACGAGTCCATAAGTGAACAATTTTATGATCGGTC ACTTGGGATCATGAGAAGGGTATTGCCTCCTGGAAACAGAAGGTACCCAAACCACCGGCACAGAGCAAGAATAAATACTGACTTTGAGTA ACGGCCTTGAGGTGTCCCTCGCCCTTTTGGTTTGTTCAAGGAGCTGCTGCTTTGCATAGCTGCTCTAGTGTCTGGTATCATCGGATCTGG TTTTGAATAATTCCCAGGAGTCCTGGGTCCCTGGCCTCCAAAGCTGGAATGTGAACGCATGCCACGGTGGTCTGACCCTCACACTCCTTT TCTCTTAACAGCAAAATGCAATGGAAGGAAGAAAAGTTCCAACAAAGAATGATTTTGTGAATTCTGTGATTTTTCTTCTGATCAGTTTCA |
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FusionGenePPI for DGKD_SPP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DGKD | DGKH, HAX1, IGSF21, DGKD, TNFRSF14, SREK1, FEZ1, TRIM25 | SPP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DGKD_SPP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DGKD_SPP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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