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Fusion gene ID: 9766 |
FusionGeneSummary for DEPDC5_ENY2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DEPDC5_ENY2 | Fusion gene ID: 9766 | Hgene | Tgene | Gene symbol | DEPDC5 | ENY2 | Gene ID | 9681 | 56943 |
| Gene name | DEP domain containing 5 | ENY2, transcription and export complex 2 subunit | |
| Synonyms | DEP.5|FFEVF|FFEVF1 | DC6|Sus1|e(y)2 | |
| Cytomap | 22q12.2-q12.3 | 8q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GATOR complex protein DEPDC5DEP domain-containing protein 5 | transcription and mRNA export factor ENY2enhancer of yellow 2 homologenhancer of yellow 2 transcription factor homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75140 | Q9NPA8 | |
| Ensembl transtripts involved in fusion gene | ENST00000535622, ENST00000400246, ENST00000266091, ENST00000382105, ENST00000400249, ENST00000382112, ENST00000382111, ENST00000400248, ENST00000494060, ENST00000536766, ENST00000400242, ENST00000539165, | ENST00000521662, ENST00000521688, ENST00000520147, ENST00000522407, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 3 X 2 X 2=12 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DEPDC5 [Title/Abstract] AND ENY2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ENY2 | GO:0016578 | histone deubiquitination | 18206972 |
| Tgene | ENY2 | GO:0045893 | positive regulation of transcription, DNA-templated | 18206972 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA838174 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000535622 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000535622 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000535622 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000535622 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400246 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400246 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400246 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000400246 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000266091 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000266091 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000266091 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000266091 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382105 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382105 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382105 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000382105 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400249 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400249 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400249 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000400249 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382112 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382112 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382112 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000382112 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382111 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382111 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000382111 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000382111 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400248 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400248 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400248 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000400248 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000494060 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000494060 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000494060 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000494060 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000536766 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000536766 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000536766 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000536766 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400242 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400242 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000400242 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000400242 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000539165 | ENST00000521662 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000539165 | ENST00000521688 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3CDS | ENST00000539165 | ENST00000520147 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
| intron-3UTR | ENST00000539165 | ENST00000522407 | DEPDC5 | chr22 | 32287159 | - | ENY2 | chr8 | 110352754 | - |
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FusionProtFeatures for DEPDC5_ENY2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEPDC5 | ENY2 |
| Involved in mRNA export coupled transcription activationby association with both the TREX-2 and the SAGA complexes. Thetranscription regulatory histone acetylation (HAT) complex SAGA isa multiprotein complex that activates transcription by remodelingchromatin and mediating histone acetylation and deubiquitination.Within the SAGA complex, participates in a subcomplex thatspecifically deubiquitinates both histones H2A and H2B. The SAGAcomplex is recruited to specific gene promoters by activators suchas MYC, where it is required for transcription. Required fornuclear receptor-mediated transactivation. The TREX-2 complexfunctions in docking export-competent ribonucleoprotein particles(mRNPs) to the nuclear entrance of the nuclear pore complex(nuclear basket). TREX-2 participates in mRNA export and accuratechromatin positioning in the nucleus by tethering genes to thenuclear periphery. {ECO:0000269|PubMed:18206972,ECO:0000269|PubMed:21746879}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DEPDC5_ENY2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DEPDC5_ENY2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DEPDC5_ENY2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DEPDC5_ENY2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DEPDC5 | C1858477 | Epilepsy, Partial, with Variable Foci | 3 | CTD_human;UNIPROT |
| Hgene | DEPDC5 | C2239176 | Liver carcinoma | 1 | CTD_human |
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