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Fusion gene ID: 9761 |
FusionGeneSummary for DEPDC1B_NPBWR1 |
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Fusion gene information | Fusion gene name: DEPDC1B_NPBWR1 | Fusion gene ID: 9761 | Hgene | Tgene | Gene symbol | DEPDC1B | NPBWR1 | Gene ID | 55789 | 2831 |
Gene name | DEP domain containing 1B | neuropeptides B and W receptor 1 | |
Synonyms | BRCC3|XTP1 | GPR7 | |
Cytomap | 5q12.1 | 8q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | DEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3 | neuropeptides B/W receptor type 1G-protein coupled receptor 7neuropeptide B/W receptor 1neuropeptides B/W receptor 1opioid-somatostatin-like receptor 7 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WUY9 | P48145 | |
Ensembl transtripts involved in fusion gene | ENST00000265036, ENST00000453022, ENST00000545085, ENST00000509006, | ENST00000331251, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DEPDC1B [Title/Abstract] AND NPBWR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NPBWR1 | GO:0007186 | G-protein coupled receptor signaling pathway | 12401809 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RU-01A | DEPDC1B | chr5 | 59982789 | - | NPBWR1 | chr8 | 53852271 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000265036 | ENST00000331251 | DEPDC1B | chr5 | 59982789 | - | NPBWR1 | chr8 | 53852271 | + |
5CDS-5UTR | ENST00000453022 | ENST00000331251 | DEPDC1B | chr5 | 59982789 | - | NPBWR1 | chr8 | 53852271 | + |
5CDS-5UTR | ENST00000545085 | ENST00000331251 | DEPDC1B | chr5 | 59982789 | - | NPBWR1 | chr8 | 53852271 | + |
intron-5UTR | ENST00000509006 | ENST00000331251 | DEPDC1B | chr5 | 59982789 | - | NPBWR1 | chr8 | 53852271 | + |
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FusionProtFeatures for DEPDC1B_NPBWR1 |
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Hgene | Tgene |
DEPDC1B | NPBWR1 |
Interacts specifically with a number of opioid ligands.Receptor for neuropeptides B and W, which may be involved inneuroendocrine system regulation, food intake and the organizationof other signals. Has a higher affinity for neuropeptide B. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DEPDC1B_NPBWR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DEPDC1B_NPBWR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DEPDC1B | MDC1, EBPL, IFI30, TCTN2, TCTN3, CETN2, TMEM17, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, PPM1H, MAST3, RTKN, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, CBY1, RAB3IP | NPBWR1 | NPW, NPB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DEPDC1B_NPBWR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DEPDC1B_NPBWR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |