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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9759

FusionGeneSummary for DEPDC1B_ELOVL7

check button Fusion gene summary
Fusion gene informationFusion gene name: DEPDC1B_ELOVL7
Fusion gene ID: 9759
HgeneTgene
Gene symbol

DEPDC1B

ELOVL7

Gene ID

55789

79993

Gene nameDEP domain containing 1BELOVL fatty acid elongase 7
SynonymsBRCC3|XTP1-
Cytomap

5q12.1

5q12.1

Type of geneprotein-codingprotein-coding
DescriptionDEP domain-containing protein 1BHBV X-transactivated gene 8 proteinHBV XAg-transactivated protein 8HBxAg transactivated protein 1breast cancer cell 3elongation of very long chain fatty acids protein 73-keto acyl-CoA synthase ELOVL7ELOVL FA elongase 7ELOVL family member 7, elongation of long chain fatty acidsvery long chain 3-ketoacyl-CoA synthase 7very long chain 3-oxoacyl-CoA synthase 7
Modification date2018052320180523
UniProtAcc

Q8WUY9

A1L3X0

Ensembl transtripts involved in fusion geneENST00000265036, ENST00000453022, 
ENST00000545085, ENST00000509006, 
ENST00000508821, ENST00000425382, 
ENST00000438340, ENST00000505959, 
Fusion gene scores* DoF score3 X 2 X 3=186 X 5 X 6=180
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/180*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DEPDC1B [Title/Abstract] AND ELOVL7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELOVL7

GO:0019367

fatty acid elongation, saturated fatty acid

19826053

TgeneELOVL7

GO:0034626

fatty acid elongation, polyunsaturated fatty acid

20937905

TgeneELOVL7

GO:0042761

very long-chain fatty acid biosynthetic process

19826053|20937905


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-VR-AA7D-01ADEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265036ENST00000508821DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000265036ENST00000425382DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000265036ENST00000438340DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000265036ENST00000505959DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000453022ENST00000508821DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000453022ENST00000425382DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000453022ENST00000438340DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5CDS-5UTRENST00000453022ENST00000505959DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5UTR-5UTRENST00000545085ENST00000508821DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5UTR-5UTRENST00000545085ENST00000425382DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5UTR-5UTRENST00000545085ENST00000438340DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
5UTR-5UTRENST00000545085ENST00000505959DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
intron-5UTRENST00000509006ENST00000508821DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
intron-5UTRENST00000509006ENST00000425382DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
intron-5UTRENST00000509006ENST00000438340DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-
intron-5UTRENST00000509006ENST00000505959DEPDC1Bchr5

59995873

-ELOVL7chr5

60083258

-

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FusionProtFeatures for DEPDC1B_ELOVL7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DEPDC1B

Q8WUY9

ELOVL7

A1L3X0

Catalyzes the first and rate-limiting reaction of thefour that constitute the long-chain fatty acids elongation cycle.This endoplasmic reticulum-bound enzymatic process, allows theaddition of 2 carbons to the chain of long- and very long-chainfatty acids/VLCFAs per cycle. Condensing enzyme with higheractivity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs andC18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-,C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or noactivity toward C22:0-, C24:0-, or C26:0-CoAs. May participate inthe production of saturated and polyunsaturated VLCFAs ofdifferent chain lengths that are involved in multiple biologicalprocesses as precursors of membrane lipids and lipid mediators.{ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:19826053,ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DEPDC1B_ELOVL7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DEPDC1B_ELOVL7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DEPDC1BMDC1, EBPL, IFI30, TCTN2, TCTN3, CETN2, TMEM17, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, PPM1H, MAST3, RTKN, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, CBY1, RAB3IPELOVL7ILF3, CERS2, DTNBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DEPDC1B_ELOVL7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DEPDC1B_ELOVL7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource