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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 9752

FusionGeneSummary for DENND5B_NUP54

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND5B_NUP54
Fusion gene ID: 9752
HgeneTgene
Gene symbol

DENND5B

NUP54

Gene ID

160518

53371

Gene nameDENN domain containing 5Bnucleoporin 54
Synonyms--
Cytomap

12p11.21

4q21.1

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 5BDENN/MADD domain containing 5Brab6IP1-like proteinnucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa
Modification date2018051920180523
UniProtAcc

Q6ZUT9

Q7Z3B4

Ensembl transtripts involved in fusion geneENST00000306833, ENST00000389082, 
ENST00000536562, ENST00000354285, 
ENST00000545147, 
ENST00000264883, 
ENST00000342467, ENST00000514987, 
ENST00000458189, ENST00000515460, 
Fusion gene scores* DoF score5 X 3 X 5=752 X 2 X 2=8
# samples 62
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: DENND5B [Title/Abstract] AND NUP54 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A12D-01ADENND5Bchr12

31743640

-NUP54chr4

77039347

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000306833ENST00000264883DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000306833ENST00000342467DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000306833ENST00000514987DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000306833ENST00000458189DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-intronENST00000306833ENST00000515460DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000389082ENST00000264883DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000389082ENST00000342467DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000389082ENST00000514987DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000389082ENST00000458189DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5CDS-intronENST00000389082ENST00000515460DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000536562ENST00000264883DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000536562ENST00000342467DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000536562ENST00000514987DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-3CDSENST00000536562ENST00000458189DENND5Bchr12

31743640

-NUP54chr4

77039347

-
intron-intronENST00000536562ENST00000515460DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000354285ENST00000264883DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000354285ENST00000342467DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000354285ENST00000514987DENND5Bchr12

31743640

-NUP54chr4

77039347

-
In-frameENST00000354285ENST00000458189DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5CDS-intronENST00000354285ENST00000515460DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5UTR-3CDSENST00000545147ENST00000264883DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5UTR-3CDSENST00000545147ENST00000342467DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5UTR-3CDSENST00000545147ENST00000514987DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5UTR-3CDSENST00000545147ENST00000458189DENND5Bchr12

31743640

-NUP54chr4

77039347

-
5UTR-intronENST00000545147ENST00000515460DENND5Bchr12

31743640

-NUP54chr4

77039347

-

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FusionProtFeatures for DENND5B_NUP54


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND5B

Q6ZUT9

NUP54

Q7Z3B4

Guanine nucleotide exchange factor (GEF) which mayactivate RAB39A and/or RAB39B. Promotes the exchange of GDP toGTP, converting inactive GDP-bound Rab proteins into their activeGTP-bound form. {ECO:0000269|PubMed:20937701}. Component of the nuclear pore complex, a complexrequired for the trafficking across the nuclear membrane.{ECO:0000250|UniProtKB:P70582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DENND5B_NUP54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_162aa
MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGPNQTGNSKEEWLCHSGXXRAVASSAGYDSGXTKCTYSVQGPTKXIDV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_487nt
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_1454nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT
TCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAAGAAGT
GCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTCCATTG
AGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTTGGAGA
TTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAATGTTT
TGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGGATATA
ACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCTTAATT

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_1453nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT
TCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAAGAAGT
GCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTCCATTG
AGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTTGGAGA
TTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAATGTTT
TGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGGATATA
ACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCTTAATT

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_912nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT
CCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATTACTGT

>In-frame_DENND5B_ENST00000389082_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_817nt
GCGAGGGCCTCTCAGGCCGACACTCCCCCCGCGCCCCTCCCCCACCCGGCCGGGCTCCGGACCCGCCGCGCGCGAGCCCGCGGCCGCTTC
CCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCGCACAG
ACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGGATGAG
CGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATCGACGC
GGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGATGAAG
AGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTCTCAAA
TCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCATTTGA
AACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAATGAAA
CCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAGACCTT

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000264883_chr4_77039347_-_1369nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT
ACTGTTCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAA
GAAGTGCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTC
CATTGAGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTT
GGAGATTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAA
TGTTTTGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGG
ATATAACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCT

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000342467_chr4_77039347_-_1368nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT
ACTGTTCATCAAATCTGAAATAGTCACCTCACAGCTCTTCAAAGAAAACCTTTGAAAGATTTATATCTAAAAGCTGTATTTACTTTAAAA
GAAGTGCATAATTACCAAAATTGTATGTACTATTGTACATTTTTACAACAGCATTTTCTTAAACATAATCTGTGTTTAATGATTATTGTC
CATTGAGCCTGTACTCTGCTTTCCATACCAAGTAAATATGAAATAATCTACTTTGCACATAACAGAACAAACTATAATTACTTGGCTGTT
GGAGATTTGTACTTGAGTATAAATGTACACCAGTTTTTGTATTTGTGAACTCATCTGTGGGAGGAGTAAAGAAAATCCAAAAGCATTTAA
TGTTTTGTTTTTGTTCTATAAAGATATGAAAATGTATTTTTATATTATTTTACTTATTTGGAATTTACAGAGCACACCTAAGCAATTAGG
ATATAACAAAACTACTTAACCATTTTTGCAACCATTTTGTTTTTTAAGCCTTTTTATTTCTAAAAAGATGAAAACTTATAAATAAATTCT

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000514987_chr4_77039347_-_827nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG
ACCTTCCTTAAGAATGAAACCGACCACATGGAGGGAAAAAGAAAACAATTCTTTCTTGGATTGGTTTTTTGAGAAGTTTACTGACAAATT

>In-frame_DENND5B_ENST00000354285_chr12_31743640_-_NUP54_ENST00000458189_chr4_77039347_-_732nt
GCTTCCCCCGCGCCGAGCGAGGAGGCAGGCTGCGGCGGCGAGAGGCGGCTGCGCGGCCATGGGCGCGCCAGTGTCGCCCTAGGGCGGGCG
CACAGACCACAGCCGGAGCGGTGGTGGCAGCCTCCGCAGAAAGCCTTCCCGGGCGGCGGCGGCGGCGGCCCCTGGAGCAGCGCGGCCGGG
ATGAGCGGGAGCTGCGCGGCGCCCGGCCCGGGCTCGGGCTCCTCCCCGGCCGCCTGCCGCTTCGCGCACTACTTCGTGCTGTGCGGGATC
GACGCGGACAGCGGGCTGGAGCCTGACGAGCTGGCGGGTCCTAATCAAACAGGAAATTCAAAGGAAGAGTGGTTATGCCATTCAGGCTGA
TGAAGAGCAGTTGCGAGTTCAGCTGGATACGATTCAGGGTGAACTAAATGCACCTACTCAGTTCAAGGGCCGACTAAATGAATTGATGTC
TCAAATCAGGATGCAGAATCATTTTGGAGCAGTCAGATCTGAAGAAAGGTATTACATAGATGCAGATCTGTTACGAGAAATCAAGCAGCA
TTTGAAACAACAACAGGAAGGCCTTAGCCATTTGATTAGCATCATTAAAGACGATCTAGAAGATATAAAGCTGGTCGAACATGGATTGAA
TGAAACCATCCACATCAGAGGTGGTGTCTTTAGTTGACAGTTCACAAACTTGTGTAAAGGTTTGTGAAATGCATCTTCTTACTGCATCAG


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FusionGenePPI for DENND5B_NUP54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DENND5BNTMT1, HSF1, GRB10, TRIM25NUP54NUP62, AP2B1, CCDC85B, NUTF2, KPNA1, KPNB1, APC, HDAC1, NUP153, SPEN, DGCR6, VCP, KRT15, HGS, NUPL1, IFT20, HAUS1, OBSL1, WDFY2, RNF166, NUP98, RAE1, NTRK1, IFI16, NUP35, SCLT1, ADD1, NUP107, TIGD6, NEDD1, NUP62CL, BFSP1, NDEL1, CEP250, LPXN, HOMER1, NDE1, CDK16, COG4, WDR59, HOMER3, EXOC1, CPNE2, CRNN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DENND5B_NUP54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DENND5B_NUP54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource