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Fusion gene ID: 9718 |
FusionGeneSummary for DENND1B_CCSER1 |
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Fusion gene information | Fusion gene name: DENND1B_CCSER1 | Fusion gene ID: 9718 | Hgene | Tgene | Gene symbol | DENND1B | CCSER1 | Gene ID | 163486 | 401145 |
Gene name | DENN domain containing 1B | coiled-coil serine rich protein 1 | |
Synonyms | C1ORF18|C1orf218|FAM31B | FAM190A | |
Cytomap | 1q31.3 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member B | serine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6P3S1 | Q9C0I3 | |
Ensembl transtripts involved in fusion gene | ENST00000400967, ENST00000235453, ENST00000367396, ENST00000477581, | ENST00000509176, ENST00000333691, ENST00000432775, ENST00000504150, | |
Fusion gene scores | * DoF score | 7 X 3 X 5=105 | 6 X 5 X 4=120 |
# samples | 7 | 6 | |
** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DENND1B [Title/Abstract] AND CCSER1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0DD-01A | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000400967 | ENST00000509176 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
intron-3CDS | ENST00000400967 | ENST00000333691 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
intron-intron | ENST00000400967 | ENST00000432775 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
intron-intron | ENST00000400967 | ENST00000504150 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-3CDS | ENST00000235453 | ENST00000509176 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-3CDS | ENST00000235453 | ENST00000333691 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-intron | ENST00000235453 | ENST00000432775 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-intron | ENST00000235453 | ENST00000504150 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
Frame-shift | ENST00000367396 | ENST00000509176 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
Frame-shift | ENST00000367396 | ENST00000333691 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5CDS-intron | ENST00000367396 | ENST00000432775 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5CDS-intron | ENST00000367396 | ENST00000504150 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-3CDS | ENST00000477581 | ENST00000509176 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-3CDS | ENST00000477581 | ENST00000333691 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-intron | ENST00000477581 | ENST00000432775 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
5UTR-intron | ENST00000477581 | ENST00000504150 | DENND1B | chr1 | 197741998 | - | CCSER1 | chr4 | 91736913 | + |
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FusionProtFeatures for DENND1B_CCSER1 |
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Hgene | Tgene |
DENND1B | CCSER1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DENND1B_CCSER1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DENND1B_CCSER1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DENND1B | SERPINA12, XPO1 | CCSER1 | NDEL1, SMYD2, NDE1, CYLD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND1B_CCSER1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND1B_CCSER1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DENND1B | C0010346 | Crohn Disease | 1 | CTD_human |
Hgene | DENND1B | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Tgene | CCSER1 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |