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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9718

FusionGeneSummary for DENND1B_CCSER1

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B_CCSER1
Fusion gene ID: 9718
HgeneTgene
Gene symbol

DENND1B

CCSER1

Gene ID

163486

401145

Gene nameDENN domain containing 1Bcoiled-coil serine rich protein 1
SynonymsC1ORF18|C1orf218|FAM31BFAM190A
Cytomap

1q31.3

4q22.1

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member Bserine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190A
Modification date2018052320180519
UniProtAcc

Q6P3S1

Q9C0I3

Ensembl transtripts involved in fusion geneENST00000400967, ENST00000235453, 
ENST00000367396, ENST00000477581, 
ENST00000509176, ENST00000333691, 
ENST00000432775, ENST00000504150, 
Fusion gene scores* DoF score7 X 3 X 5=1056 X 5 X 4=120
# samples 76
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1B [Title/Abstract] AND CCSER1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0DD-01ADENND1Bchr1

197741998

-CCSER1chr4

91736913

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000400967ENST00000509176DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
intron-3CDSENST00000400967ENST00000333691DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
intron-intronENST00000400967ENST00000432775DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
intron-intronENST00000400967ENST00000504150DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-3CDSENST00000235453ENST00000509176DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-3CDSENST00000235453ENST00000333691DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-intronENST00000235453ENST00000432775DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-intronENST00000235453ENST00000504150DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
Frame-shiftENST00000367396ENST00000509176DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
Frame-shiftENST00000367396ENST00000333691DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5CDS-intronENST00000367396ENST00000432775DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5CDS-intronENST00000367396ENST00000504150DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-3CDSENST00000477581ENST00000509176DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-3CDSENST00000477581ENST00000333691DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-intronENST00000477581ENST00000432775DENND1Bchr1

197741998

-CCSER1chr4

91736913

+
5UTR-intronENST00000477581ENST00000504150DENND1Bchr1

197741998

-CCSER1chr4

91736913

+

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FusionProtFeatures for DENND1B_CCSER1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1B

Q6P3S1

CCSER1

Q9C0I3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DENND1B_CCSER1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DENND1B_CCSER1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DENND1BSERPINA12, XPO1CCSER1NDEL1, SMYD2, NDE1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DENND1B_CCSER1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DENND1B_CCSER1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND1BC0010346Crohn Disease1CTD_human
HgeneDENND1BC0023892Biliary cirrhosis1CTD_human
TgeneCCSER1C0236736Cocaine-Related Disorders1CTD_human