|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9678 |
FusionGeneSummary for DEAF1_SH3GL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DEAF1_SH3GL1 | Fusion gene ID: 9678 | Hgene | Tgene | Gene symbol | DEAF1 | SH3GL1 | Gene ID | 10522 | 6455 |
| Gene name | DEAF1, transcription factor | SH3 domain containing GRB2 like 1, endophilin A2 | |
| Synonyms | MRD24|NUDR|SPN|ZMYND5 | CNSA1|EEN|SH3D2B|SH3P8 | |
| Cytomap | 11p15.5 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | deformed epidermal autoregulatory factor 1 homolognuclear DEAF-1-related transcriptional regulatorsuppressinzinc finger MYND domain-containing protein 5 | endophilin-A2EEN fusion partner of MLLSH3 domain protein 2BSH3 domain-containing GRB2-like protein 1SH3-containing Grb-2-like 1 proteinSH3-domain GRB2-like 1endophilin-2extra 11-19 leukemia fusionextra eleven-nineteen leukemia fusion gene protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75398 | Q99961 | |
| Ensembl transtripts involved in fusion gene | ENST00000338675, ENST00000382409, ENST00000525904, | ENST00000269886, ENST00000598564, ENST00000417295, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 5 X 4 X 5=100 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DEAF1 [Title/Abstract] AND SH3GL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DEAF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 24726472 |
| Hgene | DEAF1 | GO:0033599 | regulation of mammary gland epithelial cell proliferation | 18826651 |
| Hgene | DEAF1 | GO:0045892 | negative regulation of transcription, DNA-templated | 24726472 |
| Hgene | DEAF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 24726472 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-AAMZ-01A | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000338675 | ENST00000269886 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| intron-3CDS | ENST00000338675 | ENST00000598564 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| intron-3CDS | ENST00000338675 | ENST00000417295 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| In-frame | ENST00000382409 | ENST00000269886 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| In-frame | ENST00000382409 | ENST00000598564 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| In-frame | ENST00000382409 | ENST00000417295 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| intron-3CDS | ENST00000525904 | ENST00000269886 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| intron-3CDS | ENST00000525904 | ENST00000598564 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
| intron-3CDS | ENST00000525904 | ENST00000417295 | DEAF1 | chr11 | 686858 | - | SH3GL1 | chr19 | 4366991 | - |
Top |
FusionProtFeatures for DEAF1_SH3GL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEAF1 | SH3GL1 |
| Implicated in endocytosis. May recruit other proteins tomembranes with high curvature (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for DEAF1_SH3GL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000269886_chr19_4366991_-_622aa MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGE SNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVA ETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASS >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000598564_chr19_4366991_-_558aa MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTVSKIRGQNLCEKDLKEIQHHLKKLEGRRLDFDYK KKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMREASSRPKREYKPKPRE PFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQ >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000417295_chr19_4366991_-_574aa MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAA AAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQLV SEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQ HHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKLKRRMR EASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000269886_chr19_4366991_-_1866nt ATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGGTGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCG GCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGGAGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACG CCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGGGCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCC GCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTGCTGCAGACAATGTCTTCACCACGTCTGTGGCGAAC GCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGGACAGCCTGAACACCGAAAAAGCGACACTGATTGTC GTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTCCCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCT CTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGTACGACAGTGAGCTGCCCGTACGGTGCCGGAACATC AGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCAAGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTT GAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACGCGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTC AGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGATGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTG ACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGGCTAAGCTGACCATGCTCAACACGGTGTCCAAGATC CGGGGCCAGGTGAAGAACCCCGGCTACCCGCAGTCGGAGGGGCTTCTGGGCGAGTGCATGATCCGCCACGGGAAGGAGCTGGGCGGCGAG TCCAACTTTGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAGAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAG AACTTCATTGACCCCCTCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGAC TTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCA GAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTACCACCGG CAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCC AAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCG TCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTC GAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGAGGGCATG >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000598564_chr19_4366991_-_1674nt ATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGGTGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCG GCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGGAGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACG CCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGGGCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCC GCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTGCTGCAGACAATGTCTTCACCACGTCTGTGGCGAAC GCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGGACAGCCTGAACACCGAAAAAGCGACACTGATTGTC GTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTCCCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCT CTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGTACGACAGTGAGCTGCCCGTACGGTGCCGGAACATC AGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCAAGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTT GAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACGCGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTC AGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGATGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTG ACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGGCTAAGCTGACCATGCTCAACACGGTGTCCAAGATC CGGGGCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAG AAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATG CACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAG ATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAG CCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCT TCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAAC GACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAG >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000417295_chr19_4366991_-_1722nt ATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGGTGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCG GCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGGAGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACG CCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGGGCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCC GCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTGCTGCAGACAATGTCTTCACCACGTCTGTGGCGAAC GCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGGACAGCCTGAACACCGAAAAAGCGACACTGATTGTC GTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTCCCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCT CTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGTACGACAGTGAGCTGCCCGTACGGTGCCGGAACATC AGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCAAGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTT GAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACGCGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTC AGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGATGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTG ACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCA GAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAG CACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAG GCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTC TCGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGG GAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTC CCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCC CTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTG ACCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000269886_chr19_4366991_-_3581nt AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGG CTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGGTGAAGAACCCCGGCTACCCGCAGTCGGAGGGGCTTCTGGGCGAGT GCATGATCCGCCACGGGAAGGAGCTGGGCGGCGAGTCCAACTTTGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAG AGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGC ACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGG CGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCT CGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGG AAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCC CCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCC TGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGA CCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCC TGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCC CTGCTGCCAGGGCGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGG GGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTGACGGCTCCCTTCCCCACTCCATGGCGCCAGCC TCCTCCCCCGCTCCCCAACTTCTCGCCCAGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGCAG CCCCCACCTCCGTCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCGCAGCCTTAACAGGATGGGATCGAGGGTCCCCA TGGGGTGGCTCAGAGATAGGACCCTGGTTTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGCAC CCCCGCCTCACACACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCTCCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGA CAGAGGCCAGCTGGGATCTGCCTGAGGACAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGTAC CTTTTCAGCTTTTTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCCACACCCACC CCAGCACACCTCACACGGGACCACAGCCGCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCCAG GCTCCCCTTGCTGAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCCTCTAGACCAAGGCAGGCAGCCCCGACATCTGC TTCCTCTATCGCCCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTGAA GCCTCCGGACCCCAGGCTCTGCTCTGCCCTGCCCTGCACCCCCCTCGTCAGAAGTACATGAGGGGCGCAGAGATGAGCACACAGCTTTGG >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000598564_chr19_4366991_-_3388nt AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGG CTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGA AACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGT TCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGG ATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCAC GCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAG CCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGA GCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCG ATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCCTGCCGCAGTGAC TCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGG CGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGGGGGGCTTATCTG GGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTGACGGCTCCCTTCCCCACTCCATGGCGCCAGCCTCCTCCCCCGCT CCCCAACTTCTCGCCCAGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGCAGCCCCCACCTCCG TCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCGCAGCCTTAACAGGATGGGATCGAGGGTCCCCATGGGGTGGCTCA GAGATAGGACCCTGGTTTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGCACCCCCGCCTCACA CACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCTCCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGACAGAGGCCAGCT GGGATCTGCCTGAGGACAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGTACCTTTTCAGCTTT TTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCCACACCCACCCCAGCACACCTC ACACGGGACCACAGCCGCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCCAGGCTCCCCTTGCT GAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCCTCTAGACCAAGGCAGGCAGCCCCGACATCTGCTTCCTCTATCGC CCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTGAAGCCTCCGGACCC CAGGCTCTGCTCTGCCCTGCCCTGCACCCCCCTCGTCAGAAGTACATGAGGGGCGCAGAGATGAGCACACAGCTTTGGGCACGGTCCAGG >In-frame_DEAF1_ENST00000382409_chr11_686858_-_SH3GL1_ENST00000417295_chr19_4366991_-_2491nt AAACCCGCGGCACTAAGCTCTCTCTGAGAGGCAGAATTGCGCCGGCCGCCGGCGAGAATCTGCCTAGAGCCGTCCAGCCCTGTCGGCCGG GGACGACAGCCGCCTCAGCCTGTCAGGACAGTGAGGAGAGCAGGGGCCGAGTCTCTCGGAAGCCCTCGTGAGGACTCGGACCTATTCGGA CTGATTCGGCTTCCCACTTCGGGGAACTTCGACCCTCCTCGGTTCAGGACTCGGTCTCGGCTCGGCGGCTTCGTGCAGGTTCGGCTCCTA CTCGGGCAGCCTCTGTTCGCCTCGGCTCCGCTCCGCGGGCGGACTCGGCTCGGCTCTGCTCGGCGGCTGGCTGCCTTTTCGGTCCCTATT CGGGCGGCGGCTTCGGGCGGCCTCGGCCCAGCTCGGGCGTCCTCTTCGGGCCCCGCTTCGGGCTCCGCGACCGGCGCTTCGGGCGGTCCC GGACGGCGCCTTCGGGAAGGCTCGGCGGAGTCCGGATGGAGGACTCGGACTCGGCGGCAAAGCAGCTGGGCCTGGCTGAGGCGGCGGCGG TGGCGGCCGCGGCCGCTGTGGCGGCGGCGGCCGCGGCCGCGGCAGGAGGCGAGGCGGAGGAGCCGGTGCTGAGCAGGGACGAGGACTCGG AGGAGGACGCAGACTCGGAGGCGGAGCGGGAGACGCCGCGGGTCACGGCAGTGGCGGTGATGGCGGCGGAGCCCGGGCACATGGACATGG GCGCCGAGGCCCTGCCCGGCCCCGACGAGGCCGCCGCTGCCGCAGCCTTCGCAGAGGTGACCACAGTGACAGTGGCCAACGTGGGGGCTG CTGCAGACAATGTCTTCACCACGTCTGTGGCGAACGCGGCATCCATCTCAGGACATGTTCTGTCTGGTAGGACGGCCCTTCAGATCGGGG ACAGCCTGAACACCGAAAAAGCGACACTGATTGTCGTCCACACAGATGGGAGCATCGTGGAGACCACCGGGCTGAAAGGCCCGGCAGCTC CCCTCACCCCAGGTCCTCAGTCTCCTCCAACCCCTCTGGCTCCCGGCCAAGAAAAAGGTGGAACTAAATACAACTGGGACCCTTCTGTGT ACGACAGTGAGCTGCCCGTACGGTGCCGGAACATCAGCGGCACTCTGTACAAGAACAGGCTCGGCTCAGGCGGCCGGGGACGGTGCATCA AGCAGGGGGAGAACTGGTACAGTCCCACCGAGTTTGAGGCCATGGCAGGAAGAGCCAGCAGTAAGGACTGGAAAAGAAGCATTCGCTACG CGGGCCGACCCTTGCAGTGCCTCATCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGA TGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGGTGACGCAT TGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAGAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCC AGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGC GGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACC TCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGG ACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTG ACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACA AGCCCATCCGGACCCCTAGCCGGAGCATGCCGCCCCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGG AGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCT TCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCCTGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGG CACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGGCGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTG AGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGGGGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAAC |
Top |
FusionGenePPI for DEAF1_SH3GL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DEAF1 | LMO4, ASCC2, RAD23B, AIMP2, TK1, FHL1, CDKN1A, CDC37, PIN1, HRAS, PPP1CA, PPP1CC, GSK3A, GSK3B, PELI1, IRF3, IRF7, CREB1, CDKN2A, HRSP12, PELI2, BSPRY, SP1, SUB1, SP3 | SH3GL1 | SH3GL1, SH2D4A, DPPA4, SH3GL3, DNM1, CREBBP, PRMT1, KHDRBS1, YWHAZ, DPYSL4, SEPT8, SH3GL2, PTPRO, VIM, ITSN2, PDCD6IP, SYNJ1, LRRK2, PML, B3GAT1, AARSD1, ACTR3, ARPC2, FUBP1, RPA1, ACTR2, ANP32B, ARPC1A, ARPC4, ARPC5, ARPC5L, BAG1, CALR, CALU, CRTAP, GTF2E1, GTF2F2, KIAA1279, LAP3, NIF3L1, NSUN2, PFDN1, PFDN5, PRKACA, TRMT10A, SH3GLB2, THG1L, TP53RK, TPRKB, TTC1, SH3GLB1, DNM1L, MTA1, GPKOW, VPS37C, MAL2, FAM102A, AZU1, CCDC101, ARHGAP8, AURKA, EWSR1, NF2, POU5F1, CALM1, CDH1, TPTE2, C8G, GPX7, IMPDH1, FBXO32 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DEAF1_SH3GL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DEAF1_SH3GL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DEAF1 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Hgene | DEAF1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Hgene | DEAF1 | C0011570 | Mental Depression | 4 | PSYGENET |
| Hgene | DEAF1 | C0011581 | Depressive disorder | 4 | PSYGENET |
| Hgene | DEAF1 | C4014414 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 24 | 2 | UNIPROT |
| Hgene | DEAF1 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|