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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9664

FusionGeneSummary for DDX60L_DDX60L

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX60L_DDX60L
Fusion gene ID: 9664
HgeneTgene
Gene symbol

DDX60L

DDX60L

Gene ID

91351

91351

Gene nameDExD/H-box 60 likeDExD/H-box 60 like
Synonyms--
Cytomap

4q32.3

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX60-likeDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-likeDEAD box protein 60-likeDEAD-box helicase 60 likeputative ATP-dependent RNA helicase DDX60probable ATP-dependent RNA helicase DDX60-likeDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-likeDEAD box protein 60-likeDEAD-box helicase 60 likeputative ATP-dependent RNA helicase DDX60
Modification date2018051920180519
UniProtAcc

Q5H9U9

Q5H9U9

Ensembl transtripts involved in fusion geneENST00000260184, ENST00000511577, 
ENST00000505890, ENST00000515088, 
ENST00000260184, ENST00000511577, 
ENST00000505890, ENST00000515088, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DDX60L [Title/Abstract] AND DDX60L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI432413DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000260184ENST00000260184DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000260184ENST00000511577DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000260184ENST00000505890DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000260184ENST00000515088DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000511577ENST00000260184DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000511577ENST00000511577DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000511577ENST00000505890DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000511577ENST00000515088DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000505890ENST00000260184DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000505890ENST00000511577DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000505890ENST00000505890DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000505890ENST00000515088DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000515088ENST00000260184DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000515088ENST00000511577DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000515088ENST00000505890DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-
intron-intronENST00000515088ENST00000515088DDX60Lchr4

169314066

-DDX60Lchr4

169339266

-

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FusionProtFeatures for DDX60L_DDX60L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX60L

Q5H9U9

DDX60L

Q5H9U9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDX60L_DDX60L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDX60L_DDX60L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDX60L_DDX60L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDX60L_DDX60L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource