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Fusion gene ID: 9663 |
FusionGeneSummary for DDX60L_CPE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX60L_CPE | Fusion gene ID: 9663 | Hgene | Tgene | Gene symbol | DDX60L | CPE | Gene ID | 91351 | 1363 |
| Gene name | DExD/H-box 60 like | carboxypeptidase E | |
| Synonyms | - | CPH | |
| Cytomap | 4q32.3 | 4q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX60-likeDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-likeDEAD box protein 60-likeDEAD-box helicase 60 likeputative ATP-dependent RNA helicase DDX60 | carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q5H9U9 | P16870 | |
| Ensembl transtripts involved in fusion gene | ENST00000260184, ENST00000511577, ENST00000505890, ENST00000515088, | ENST00000402744, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 5 X 5=150 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX60L [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CPE | GO:0016055 | Wnt signaling pathway | 22824791 |
| Tgene | CPE | GO:0072657 | protein localization to membrane | 19166515 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-G3-A3CH-01A | DDX60L | chr4 | 169393606 | - | CPE | chr4 | 166405574 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000260184 | ENST00000402744 | DDX60L | chr4 | 169393606 | - | CPE | chr4 | 166405574 | + |
| In-frame | ENST00000511577 | ENST00000402744 | DDX60L | chr4 | 169393606 | - | CPE | chr4 | 166405574 | + |
| In-frame | ENST00000505890 | ENST00000402744 | DDX60L | chr4 | 169393606 | - | CPE | chr4 | 166405574 | + |
| 5UTR-3CDS | ENST00000515088 | ENST00000402744 | DDX60L | chr4 | 169393606 | - | CPE | chr4 | 166405574 | + |
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FusionProtFeatures for DDX60L_CPE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX60L | CPE |
| Removes residual C-terminal Arg or Lys remaining afterinitial endoprotease cleavage during prohormone processing.Processes proinsulin. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000260184 | - | 3 | 38 | 1205_1354 | 24 | 1707 | Domain | Helicase C-terminal |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000260184 | - | 3 | 38 | 752_919 | 24 | 1707 | Domain | Helicase ATP-binding |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000505890 | - | 3 | 30 | 1205_1354 | 24 | 1309 | Domain | Helicase C-terminal |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000505890 | - | 3 | 30 | 752_919 | 24 | 1309 | Domain | Helicase ATP-binding |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000511577 | - | 3 | 38 | 1205_1354 | 24 | 1707 | Domain | Helicase C-terminal |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000511577 | - | 3 | 38 | 752_919 | 24 | 1707 | Domain | Helicase ATP-binding |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000260184 | - | 3 | 38 | 869_872 | 24 | 1707 | Motif | Note=DEAH box |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000505890 | - | 3 | 30 | 869_872 | 24 | 1309 | Motif | Note=DEAH box |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000511577 | - | 3 | 38 | 869_872 | 24 | 1707 | Motif | Note=DEAH box |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000260184 | - | 3 | 38 | 765_772 | 24 | 1707 | Nucleotide binding | ATP |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000505890 | - | 3 | 30 | 765_772 | 24 | 1309 | Nucleotide binding | ATP |
| Hgene | >DDX60L | chr4:169393606 | chr4:166405574 | ENST00000511577 | - | 3 | 38 | 765_772 | 24 | 1707 | Nucleotide binding | ATP |
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FusionGeneSequence for DDX60L_CPE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDX60L_ENST00000260184_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_238aa MGSKDHAVFFREMTQLILNEMPKAGXCSRIQLLPRXRHFPKLGPGILFFQPGHVXPQSATMSQEXXXQQLCRWNHQRWCLVQRTWRDARL QLPXQQLFXDHRGAXLXEVPTXRDSEDLLGGXQKLPHXLPXADTPRSXRICPRPSRXPNCECHHLRGRNRPRCYIRKGWXLLEIAYTWKL >In-frame_DDX60L_ENST00000511577_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_238aa MGSKDHAVFFREMTQLILNEMPKAGXCSRIQLLPRXRHFPKLGPGILFFQPGHVXPQSATMSQEXXXQQLCRWNHQRWCLVQRTWRDARL QLPXQQLFXDHRGAXLXEVPTXRDSEDLLGGXQKLPHXLPXADTPRSXRICPRPSRXPNCECHHLRGRNRPRCYIRKGWXLLEIAYTWKL >In-frame_DDX60L_ENST00000505890_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_238aa MGSKDHAVFFREMTQLILNEMPKAGXCSRIQLLPRXRHFPKLGPGILFFQPGHVXPQSATMSQEXXXQQLCRWNHQRWCLVQRTWRDARL QLPXQQLFXDHRGAXLXEVPTXRDSEDLLGGXQKLPHXLPXADTPRSXRICPRPSRXPNCECHHLRGRNRPRCYIRKGWXLLEIAYTWKL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDX60L_ENST00000260184_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_715nt ATGGGGTCAAAGGATCATGCAGTATTTTTCAGGGAAATGACACAGTTAATTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATA CAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACC ATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTT CAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGA GGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGC GAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTA TAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACT >In-frame_DDX60L_ENST00000511577_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_715nt ATGGGGTCAAAGGATCATGCAGTATTTTTCAGGGAAATGACACAGTTAATTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATA CAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACC ATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTT CAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGA GGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGC GAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTA TAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACT >In-frame_DDX60L_ENST00000505890_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_715nt ATGGGGTCAAAGGATCATGCAGTATTTTTCAGGGAAATGACACAGTTAATTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATA CAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACC ATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTT CAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGA GGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGC GAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTA TAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDX60L_ENST00000260184_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_1646nt AGAGCGCCCAGTCCGACGCCAGGCTCTGCGCTCGGTCTCCTCTGCTCCACCTCCTCCCCGCGGGGCGTGCAGCTCCGAAGCTCTTTGGAC CTAGCAGGTTCGGCGGCCGGGAGGTGCCATTCACATCAAATGTAGCCATTTTAGAGGTGTCAAAATAAATCAGCCATATTTAATAAATTC CAGCTCTACTCTTCTACCCTGTAGCCCAAGAAGCAGCAACGATGGGGTCAAAGGATCATGCAGTATTTTTCAGGGAAATGACACAGTTAA TTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATAC TCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAAC GGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGT GAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGA GTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCA AAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTG GCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAA TGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGTTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAA TGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTAATCATTTAAATATTAATCAACTTTCCTTAAAATA AATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTCATTTTCCTACCTATATTACACAAAAAAGTA TAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAATATTCCTGGTATTATTTACAATGCAGAATTTTTTGAGTAATTCTAG CTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAATGTCACATAATGAATGCTATTGAAAAGGTTAACAGATACAGCTCGGA GTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAATTGTCGTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTA ATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGTTTTATGAAAAGAATAAAAATTGACTTCTTGCTTGTACATATAGGAG CAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTTTAGGGTTTTCTCTTGGTTGTAGAGTGGCCCAGAATTGCATTCTGAA >In-frame_DDX60L_ENST00000511577_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_1673nt ACTCAGGCGCTGGCTGCTGTGTGGCTCAGAGCGCCCAGTCCGACGCCAGGCTCTGCGCTCGGTCTCCTCTGCTCCACCTCCTCCCCGCGG GGCGTGCAGCTCCGAAGCTCTTTGGACCTAGCAGGTTCGGCGGCCGGGAGGTGCCATTCACATCAAATGTAGCCATTTTAGAGGTGTCAA AATAAATCAGCCATATTTAATAAATTCCAGCTCTACTCTTCTACCCTGTAGCCCAAGAAGCAGCAACGATGGGGTCAAAGGATCATGCAG TATTTTTCAGGGAAATGACACAGTTAATTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATACAGCTCCTCCCCAGATGACGCC ATTTTCCAAAGCTTGGCCCGGGCATACTCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGATGATGAC AGCAGCTTTGTAGATGGAACCACCAACGGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGT TTTGAGATCACCGTGGAGCTTAGCTGTGAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCATT AGCTACCTTGAGCAGATACACCGAGGAGTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTCCGTGGAA GGAATAGACCACGATGTTACATCCGCAAAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTCCA GGCTATCTGGCAATAACAAAGAAAGTGGCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAA GAAGAGGAGAAGGAAGAATTGATGGAATGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGTTAGCTGCTTTAAAT CTATCTATATAATGTAGTATGATGTAATGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTAATCATTT AAATATTAATCAACTTTCCTTAAAATAAATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTCATT TTCCTACCTATATTACACAAAAAAGTATAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAATATTCCTGGTATTATTTAC AATGCAGAATTTTTTGAGTAATTCTAGCTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAATGTCACATAATGAATGCTAT TGAAAAGGTTAACAGATACAGCTCGGAGTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAATTGTCGTTTTTTTCTTGTGC TGACTAACTATAAGCATGATCTTGTTAATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGTTTTATGAAAAGAATAAAAA TTGACTTCTTGCTTGTACATATAGGAGCAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTTTAGGGTTTTCTCTTGGTTG >In-frame_DDX60L_ENST00000505890_chr4_169393606_-_CPE_ENST00000402744_chr4_166405574_+_1646nt AGAGCGCCCAGTCCGACGCCAGGCTCTGCGCTCGGTCTCCTCTGCTCCACCTCCTCCCCGCGGGGCGTGCAGCTCCGAAGCTCTTTGGAC CTAGCAGGTTCGGCGGCCGGGAGGTGCCATTCACATCAAATGTAGCCATTTTAGAGGTGTCAAAATAAATCAGCCATATTTAATAAATTC CAGCTCTACTCTTCTACCCTGTAGCCCAAGAAGCAGCAACGATGGGGTCAAAGGATCATGCAGTATTTTTCAGGGAAATGACACAGTTAA TTTTGAATGAAATGCCAAAAGCTGGGTAGTGCTCACGAATACAGCTCCTCCCCAGATGACGCCATTTTCCAAAGCTTGGCCCGGGCATAC TCTTCTTTCAACCCGGCCATGTCTGACCCCAATCGGCCACCATGTCGCAAGAATGATGATGACAGCAGCTTTGTAGATGGAACCACCAAC GGTGGTGCTTGGTACAGCGTACCTGGAGGGATGCAAGACTTCAATTACCTTAGCAGCAACTGTTTTGAGATCACCGTGGAGCTTAGCTGT GAGAAGTTCCCACCTGAAGAGACTCTGAAGACCTACTGGGAGGATAACAAAAACTCCCTCATTAGCTACCTTGAGCAGATACACCGAGGA GTTAAAGGATTTGTCCGAGACCTTCAAGGTAACCCAATTGCGAATGCCACCATCTCCGTGGAAGGAATAGACCACGATGTTACATCCGCA AAGGATGGTGATTACTGGAGATTGCTTATACCTGGAAACTATAAACTTACAGCCTCAGCTCCAGGCTATCTGGCAATAACAAAGAAAGTG GCAGTTCCTTACAGCCCTGCTGCTGGGGTTGATTTTGAACTGGAGTCATTTTCTGAAAGGAAAGAAGAGGAGAAGGAAGAATTGATGGAA TGGTGGAAAATGATGTCAGAAACTTTAAATTTTTAAAAAGGCTTCTAGTTAGCTGCTTTAAATCTATCTATATAATGTAGTATGATGTAA TGTGGTCTTTTTTTTAGATTTTGTGCAGTTAATACTTAACATTGATTTATTTTTTAATCATTTAAATATTAATCAACTTTCCTTAAAATA AATAGCCTCTTAGGTAAAAATATAAGAACTTGATATATTTCATTCTCTTATATAGTATTCATTTTCCTACCTATATTACACAAAAAAGTA TAGAAAAGATTTAAGTAATTTTGCCATCCTAGGCTTAAATGCAATATTCCTGGTATTATTTACAATGCAGAATTTTTTGAGTAATTCTAG CTTTCAAAAATTAGTGAAGTTCTTTTACTGTAATTGGTGACAATGTCACATAATGAATGCTATTGAAAAGGTTAACAGATACAGCTCGGA GTTGTGAGCACTCTACTGCAAGACTTAAATAGTTCAGTATAAATTGTCGTTTTTTTCTTGTGCTGACTAACTATAAGCATGATCTTGTTA ATGCATTTTTGATGGGAAGAAAAGGTACATGTTTACAAAGAGGTTTTATGAAAAGAATAAAAATTGACTTCTTGCTTGTACATATAGGAG CAATACTATTATATTATGTAGTCCGTTAACACTACTTAAAAGTTTAGGGTTTTCTCTTGGTTGTAGAGTGGCCCAGAATTGCATTCTGAA |
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FusionGenePPI for DDX60L_CPE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDX60L | ABCB9, IFI16, ZSCAN26, RBM3 | CPE | ROBO2, CHD3, GTF3C1, POLA2, POLDIP2, RPA1, UTP14A, MED31, LRIF1, PRKAA1, NUFIP1, SERPINB11, SIAE, RNASE13, PSG8, SLAMF1, SCGB1D1, PSG1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDX60L_CPE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CPE | P16870 | DB00071 | Insulin Pork | Carboxypeptidase E | biotech | approved |
| Tgene | CPE | P16870 | DB00030 | Insulin Human | Carboxypeptidase E | biotech | approved|investigational |
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RelatedDiseases for DDX60L_CPE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CPE | C0028754 | Obesity | 2 | CTD_human |
| Tgene | CPE | C0014130 | Endocrine System Diseases | 1 | CTD_human |
| Tgene | CPE | C0021655 | Insulin Resistance | 1 | CTD_human |
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