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Fusion gene ID: 9638 |
FusionGeneSummary for DDX52_STAT5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX52_STAT5B | Fusion gene ID: 9638 | Hgene | Tgene | Gene symbol | DDX52 | STAT5B | Gene ID | 11056 | 6777 |
| Gene name | DExD-box helicase 52 | signal transducer and activator of transcription 5B | |
| Synonyms | HUSSY19|ROK1 | STAT5 | |
| Cytomap | 17q12 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52DEAD box protein 52DEAD-box helicase 52 | signal transducer and activator of transcription 5Btranscription factor STAT5B | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9Y2R4 | P51692 | |
| Ensembl transtripts involved in fusion gene | ENST00000349699, ENST00000394367, | ENST00000293328, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 4 X 2 X 4=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DDX52 [Title/Abstract] AND STAT5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STAT5B | GO:0032355 | response to estradiol | 12552091 |
| Tgene | STAT5B | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| Tgene | STAT5B | GO:0045648 | positive regulation of erythrocyte differentiation | 20702587 |
| Tgene | STAT5B | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-XD-AAUI-01A | DDX52 | chr17 | 35988605 | - | STAT5B | chr17 | 40354826 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000349699 | ENST00000293328 | DDX52 | chr17 | 35988605 | - | STAT5B | chr17 | 40354826 | - |
| In-frame | ENST00000394367 | ENST00000293328 | DDX52 | chr17 | 35988605 | - | STAT5B | chr17 | 40354826 | - |
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FusionProtFeatures for DDX52_STAT5B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX52 | STAT5B |
| Carries out a dual function: signal transduction andactivation of transcription. Mediates cellular responses to thecytokine KITLG/SCF and other growth factors. Binds to the GASelement and activates PRL-induced transcription. Positivelyregulates hematopoietic/erythroid differentiation.{ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:8732682}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 165_193 | 286 | 600 | Motif | Note=Q motif |
| Hgene | DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 209_216 | 286 | 600 | Nucleotide binding | Note=ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 543_592 | 286 | 600 | Compositional bias | Note=Lys-rich |
| Hgene | >DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 196_374 | 286 | 600 | Domain | Helicase ATP-binding |
| Hgene | >DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 385_546 | 286 | 600 | Domain | Helicase C-terminal |
| Hgene | >DDX52 | chr17:35988605 | chr17:40354826 | ENST00000349699 | - | 6 | 15 | 318_321 | 286 | 600 | Motif | Note=DEAD box |
| Tgene | STAT5B | chr17:35988605 | chr17:40354826 | ENST00000293328 | - | 15 | 19 | 589_686 | 692 | 788 | Domain | SH2 |
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FusionGeneSequence for DDX52_STAT5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDX52_ENST00000349699_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_382aa MDVHDLFRRLGAGAKFDTRRFSADAARFQIGKRKYDFDSSEVLQGLDFFGNKKSVPGVCGASQTHQKPQNGEKKEESLTERKREQSKKKR KTMTSEIASQEEGATIQWMSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNI LDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHK AAVAAKKFGPKSSKKFAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVA >In-frame_DDX52_ENST00000394367_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_274aa MSSVEAKIEDKKVQRESKLTSGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILDAGFQMPTPIQMQAIPV MLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFAK AVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDX52_ENST00000349699_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_1146nt ATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAATTCGACACGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATA GGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGACTGGACTTTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGA GCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAGAGAGCCTAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGG AAGACGATGACTTCAGAAATTGCTTCCCAAGAAGAAGGTGCTACTATACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAA GTTCAGAGAGAAAGTAAACTAACTTCCGGAAAGTTGGAGAATCTCAGAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCAC GTCCAAGGAACCGATCTTCCTGACCCAATTGCTACATTTCAGCAACTTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATT CTAGATGCAGGTTTCCAAATGCCTACGCCAATCCAAATGCAAGCCATCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCA ACTGGATCTGGAAAAACATTAGCTTTTAGCATTCCTATTTTAATGCAGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATA TCACCAACACGAGAACTTGCCAGCCAGATTCACAGAGAGTTAATAAAAATTTCTGAGGGAACAGGATTCAGGATACACATGATCCACAAA GCAGCAGTGGCAGCCAAGAAATTTGGACCTAAATCATCTAAAAAGTTTGCTAAAGCTGTTGATGGATACGTGAAGCCACAGATCAAGCAA GTGGTCCCTGAGTTTGTGAACGCATCTGCAGATGCCGGGGGCGGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGTCCC CAGGCTCACTATAACATGTACCCACAGAACCCTGACTCAGTCCTTGACACCGATGGGGACTTCGATCTGGAGGACACAATGGACGTAGCG >In-frame_DDX52_ENST00000394367_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_822nt ATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCCGGAAAGTTGGAGAATCTCAGAAAAGAA AAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCAATTGCTACATTTCAGCAACTTGACCAG GAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACGCCAATCCAAATGCAAGCCATCCCAGTT ATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTTAGCATTCCTATTTTAATGCAGCTGAAA CAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAGATTCACAGAGAGTTAATAAAAATTTCT GAGGGAACAGGATTCAGGATACACATGATCCACAAAGCAGCAGTGGCAGCCAAGAAATTTGGACCTAAATCATCTAAAAAGTTTGCTAAA GCTGTTGATGGATACGTGAAGCCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAACGCATCTGCAGATGCCGGGGGCGGCAGCGCCACG TACATGGACCAGGCCCCCTCCCCAGCTGTGTGTCCCCAGGCTCACTATAACATGTACCCACAGAACCCTGACTCAGTCCTTGACACCGAT GGGGACTTCGATCTGGAGGACACAATGGACGTAGCGCGGCGTGTGGAGGAGCTCCTGGGCCGGCCAATGGACAGTCAGTGGATCCCGCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDX52_ENST00000349699_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_3760nt AGTCTGCGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAAT TCGACACGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGAC TGGACTTTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAG AGAGCCTAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAAATTGCTTCCCAAGAAGAAGGTGCTACTA TACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCCGGAAAGTTGGAGAATCTCA GAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCAATTGCTACATTTCAGCAAC TTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACGCCAATCCAAATGCAAGCCA TCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTTAGCATTCCTATTTTAATGC AGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAGATTCACAGAGAGTTAATAA AAATTTCTGAGGGAACAGGATTCAGGATACACATGATCCACAAAGCAGCAGTGGCAGCCAAGAAATTTGGACCTAAATCATCTAAAAAGT TTGCTAAAGCTGTTGATGGATACGTGAAGCCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAACGCATCTGCAGATGCCGGGGGCGGCA GCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGTCCCCAGGCTCACTATAACATGTACCCACAGAACCCTGACTCAGTCCTTG ACACCGATGGGGACTTCGATCTGGAGGACACAATGGACGTAGCGCGGCGTGTGGAGGAGCTCCTGGGCCGGCCAATGGACAGTCAGTGGA TCCCGCACGCACAATCGTGACCCCGCGACCTCTCCATCTTCAGCTTCTTCATCTTCACCAGAGGAATCACTCTTGTGGATGTTTTAATTC CATGAATCGCTTCTCTTTTGAAACAATACTCATAATGTGAAGTGTTAATACTAGTTGTGACCTTAGTGTTTCTGTGCATGGTGGCACCAG CGAAGGGAGTGCGAGTATGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGTGTTTGCACGTTATGGTGTTTCTCCCTCTCACTGT CTGAGAGTTTAGTTGTAGCAGAGGGGCCACAGACAGAAGCTGTGGTGGTTTTTACTTTGTGCAAAAAGGCAGTGAGTTTCGTGAAGCCTG GAAGTTGGCCATGTGTCTTAAGAGTGGCTGGACTTTGACATGTGGCTGTTTGAATAAGAGAAGGACAAAGGGAGGAGAAAGCACATGTGC TCCAGTGAGTCTTCGTCACTCTGTCTGCCAAGCAATTGATATATAACCGTGATTGTCTCTGCTTTTCTTCTGAAATGTAGATAACTGCTT TTTGACAAAGAGAGCCTTCCCTCTCCCCCACCCCTGTGTTCTTGGGTAGGAATGGGAAAAGGGGCAACCTACAAAGATTGTTGGGGCAAG GGAAGTCACAAGCTTTCGGATGGGCGGTGGCTTTTCACAAAACATTTAGCTCATCTTATTCTCTCTTTGTCCTCTCTCCCCTCCTGCCCG CCCGCACCCTGGAATTGCCACTCAGTTCCTCTGGGTGTGCACATATGTTTGGAGAAATAGAGGAGAGAAAAGAGGGCCACGTAACTGAGA GCTTACAGTGCCAATGCCGTTTGTGTTCTGGCCAGAGTGGAGTGCGCAGCCCTGACTCCCAGGCGCTGAGATTGTTGCCTGGTTACCCAG GAAGCTGCTGTTCCGGCTGCCCAGCCTTTCTCTGAGCCAGCGGATGCACAGTCCGTGGCCTTCTTCAGGCTTATTGATGATGCTTTTTGC AAATGTTGAATCATGGTTCTGTTTCTAAGTTGGATCTTTTTTGTTTTCTCCTTGCCACCCTAATTTGACATCAAAATTCTCTCTTGTGCA TTGGGCCCTGGGTCATTCAAACCCAGGTCACCTCATTCCCCTTCTCTGTTCACACCTAATGTCTTGAAGAGTAGGTAGCAGCAGTGTGGG CTGAACCTAGGCCAGCTTGCTTAGCGGGTCACCCTGCTGTGAAGTCCTGGCAGGTGTTGGTAATGTGTGGAAATGCAGTCAGCAAGTTTG CTGGGGAGTTTGATAAAAGTATAAAACAAAACAAAAAAAGCCTCGGTATAATTTTGTTCCACGACTTCTTCTGTAGCTTTACACCAGAAG GAAGGAATGGGCTACAGCAGGTAGTGGAGGAAGAGGGGGGTGAGCAGGTGTATTAAAATAGCTTACGGGTAAGGCCTAAAAGGTCACCCC TCGGCCCCCTCTCCAAAAGAAGGGCATGGGCACCCCCAGGAGAGGATGGCCCCAAAAACCTTATTTTTATACATGAGAGTAAATAAACAT ATTTTTTTTACAAAAATAACTTCTGAATTTATCAGTGTTTTGCCGTTAAAAATATTCCTCTATAGTAAATTATTTATTGGAAGATGACTT TTTTAAAGCTGCCGTTTGCCTTGGCTTGGTTTCATACACTGATTTATTTTTCTATGCCAGGCAGTAGAGTCTCTCTGCCTCTGAGGAGCA GGCTACCCGCATCCCACTCAGCCCCTCCCTACCCCTCAAGATTTGATGAAAATTCCAACCATGAGGATGGGTGCATCGGGGAAGGGTGAG AAGGAGAGCCTGCCTGCTCAGGGATCCAGGCTCGTAGAGTCACTCCCTGCCCGTCTCCCAGAGATGCTTCACCAGCACCTGCCTCTGAGA CCTCGCTCTCTGTTCCAGCAACCCTGGTTGGGGGGTCAGACTTGATACACTTTCAGGTTGGGAGTGGACCCACCCCAGGGCCTGCTGAGG ACAGAGCAGCCAGGCCGTCCTGGCTCACTTTGCAGTTGGCACTGGGTTGGGGAGGAAGAGAGCTGATGAGTGTGGCTTCCCTGAGCTGGG GTTTCCCTGCTTGTCCAGTTGTGAGCTGTCCTCGGTGTTACCGAGGCTGTGCCTAGAGAGTGGAGATTTTTGATGAAAGGTGTGCTCGCT CTCTGCGTTCTATCTTCTCTCTCCTCCTTGTTCCTGCAAACCACAAGATAAAGGTAGTGGTGTGTCTCGACCCCATCAGCCTCTCACCCA CTCCCAGACACACACAAGTCCTCAAAAGTTTCAGCTCCGTGTGTGAGATGTGCAGGTTTTTTCTAGGGGGTAGGGGGAGACTAAAATCGA ATATAACTTAAAATGAAAGTATACTTTTTATAATTTTTCTTTTTAAAACTTGGTGAAATTATTTCAGATACATATTTTAGTGTCAAGGCA GATTAGTTATTTAGCCACCAAAAAAAAGTATTGTGTACAATTTGGGGCCTCAAATTTGACTCTGCCTCAAAAAAAAGAAATATATCCTAT >In-frame_DDX52_ENST00000394367_chr17_35988605_-_STAT5B_ENST00000293328_chr17_40354826_-_3869nt CGCAGGCGCCGTAGAACTGTGGCGCTTTCTGGGTAAAGATGGACGTCCACGATCTCTTTCGCCGGCTCGGCGCGGGGGCCAAATTCGACA CGAGACGCTTCTCGGCAGACGCAGCTCGATTCCAGATAGGAAAAAGGAAATATGACTTTGATTCTTCGGAGGTGCTTCAGGGACTGGACT TTTTTGGAAACAAGAAGTCTGTCCCAGGTGTGTGTGGAGCATCACAAACACATCAGAAGCCCCAAAATGGAGAGAAAAAAGAAGAGAGCC TAACTGAAAGGAAGAGGGAGCAGAGCAAGAAAAAAAGGAAGACGATGACTTCAGAGACAGGGTTTCACCATGTTAGCCAGTATGGTCTCG ATCTCCTGACCTCGTGATTCACCCACCTTGGGCTCCCAAAGTGCTGGGATTACAGATGTGAGCCACCACGCCCAGCCAGAAATTGCTTCC CAAGAAGAAGGTGCTACTATACAGTGGATGTCATCTGTAGAAGCAAAGATTGAAGACAAAAAAGTTCAGAGAGAAAGTAAACTAACTTCC GGAAAGTTGGAGAATCTCAGAAAAGAAAAGATAAACTTCTTGCGGAATAAACACAAAATTCACGTCCAAGGAACCGATCTTCCTGACCCA ATTGCTACATTTCAGCAACTTGACCAGGAATATAAAATCAATTCTCGACTACTTCAGAACATTCTAGATGCAGGTTTCCAAATGCCTACG CCAATCCAAATGCAAGCCATCCCAGTTATGCTGCATGGTCGGGAACTTCTGGCTTCTGCTCCAACTGGATCTGGAAAAACATTAGCTTTT AGCATTCCTATTTTAATGCAGCTGAAACAACCCGCAAATAAAGGCTTCAGAGCCCTGATTATATCACCAACACGAGAACTTGCCAGCCAG ATTCACAGAGAGTTAATAAAAATTTCTGAGGGAACAGGATTCAGGATACACATGATCCACAAAGCAGCAGTGGCAGCCAAGAAATTTGGA CCTAAATCATCTAAAAAGTTTGCTAAAGCTGTTGATGGATACGTGAAGCCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAACGCATCT GCAGATGCCGGGGGCGGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGTCCCCAGGCTCACTATAACATGTACCCACAG AACCCTGACTCAGTCCTTGACACCGATGGGGACTTCGATCTGGAGGACACAATGGACGTAGCGCGGCGTGTGGAGGAGCTCCTGGGCCGG CCAATGGACAGTCAGTGGATCCCGCACGCACAATCGTGACCCCGCGACCTCTCCATCTTCAGCTTCTTCATCTTCACCAGAGGAATCACT CTTGTGGATGTTTTAATTCCATGAATCGCTTCTCTTTTGAAACAATACTCATAATGTGAAGTGTTAATACTAGTTGTGACCTTAGTGTTT CTGTGCATGGTGGCACCAGCGAAGGGAGTGCGAGTATGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGTGTTTGCACGTTATGG TGTTTCTCCCTCTCACTGTCTGAGAGTTTAGTTGTAGCAGAGGGGCCACAGACAGAAGCTGTGGTGGTTTTTACTTTGTGCAAAAAGGCA GTGAGTTTCGTGAAGCCTGGAAGTTGGCCATGTGTCTTAAGAGTGGCTGGACTTTGACATGTGGCTGTTTGAATAAGAGAAGGACAAAGG GAGGAGAAAGCACATGTGCTCCAGTGAGTCTTCGTCACTCTGTCTGCCAAGCAATTGATATATAACCGTGATTGTCTCTGCTTTTCTTCT GAAATGTAGATAACTGCTTTTTGACAAAGAGAGCCTTCCCTCTCCCCCACCCCTGTGTTCTTGGGTAGGAATGGGAAAAGGGGCAACCTA CAAAGATTGTTGGGGCAAGGGAAGTCACAAGCTTTCGGATGGGCGGTGGCTTTTCACAAAACATTTAGCTCATCTTATTCTCTCTTTGTC CTCTCTCCCCTCCTGCCCGCCCGCACCCTGGAATTGCCACTCAGTTCCTCTGGGTGTGCACATATGTTTGGAGAAATAGAGGAGAGAAAA GAGGGCCACGTAACTGAGAGCTTACAGTGCCAATGCCGTTTGTGTTCTGGCCAGAGTGGAGTGCGCAGCCCTGACTCCCAGGCGCTGAGA TTGTTGCCTGGTTACCCAGGAAGCTGCTGTTCCGGCTGCCCAGCCTTTCTCTGAGCCAGCGGATGCACAGTCCGTGGCCTTCTTCAGGCT TATTGATGATGCTTTTTGCAAATGTTGAATCATGGTTCTGTTTCTAAGTTGGATCTTTTTTGTTTTCTCCTTGCCACCCTAATTTGACAT CAAAATTCTCTCTTGTGCATTGGGCCCTGGGTCATTCAAACCCAGGTCACCTCATTCCCCTTCTCTGTTCACACCTAATGTCTTGAAGAG TAGGTAGCAGCAGTGTGGGCTGAACCTAGGCCAGCTTGCTTAGCGGGTCACCCTGCTGTGAAGTCCTGGCAGGTGTTGGTAATGTGTGGA AATGCAGTCAGCAAGTTTGCTGGGGAGTTTGATAAAAGTATAAAACAAAACAAAAAAAGCCTCGGTATAATTTTGTTCCACGACTTCTTC TGTAGCTTTACACCAGAAGGAAGGAATGGGCTACAGCAGGTAGTGGAGGAAGAGGGGGGTGAGCAGGTGTATTAAAATAGCTTACGGGTA AGGCCTAAAAGGTCACCCCTCGGCCCCCTCTCCAAAAGAAGGGCATGGGCACCCCCAGGAGAGGATGGCCCCAAAAACCTTATTTTTATA CATGAGAGTAAATAAACATATTTTTTTTACAAAAATAACTTCTGAATTTATCAGTGTTTTGCCGTTAAAAATATTCCTCTATAGTAAATT ATTTATTGGAAGATGACTTTTTTAAAGCTGCCGTTTGCCTTGGCTTGGTTTCATACACTGATTTATTTTTCTATGCCAGGCAGTAGAGTC TCTCTGCCTCTGAGGAGCAGGCTACCCGCATCCCACTCAGCCCCTCCCTACCCCTCAAGATTTGATGAAAATTCCAACCATGAGGATGGG TGCATCGGGGAAGGGTGAGAAGGAGAGCCTGCCTGCTCAGGGATCCAGGCTCGTAGAGTCACTCCCTGCCCGTCTCCCAGAGATGCTTCA CCAGCACCTGCCTCTGAGACCTCGCTCTCTGTTCCAGCAACCCTGGTTGGGGGGTCAGACTTGATACACTTTCAGGTTGGGAGTGGACCC ACCCCAGGGCCTGCTGAGGACAGAGCAGCCAGGCCGTCCTGGCTCACTTTGCAGTTGGCACTGGGTTGGGGAGGAAGAGAGCTGATGAGT GTGGCTTCCCTGAGCTGGGGTTTCCCTGCTTGTCCAGTTGTGAGCTGTCCTCGGTGTTACCGAGGCTGTGCCTAGAGAGTGGAGATTTTT GATGAAAGGTGTGCTCGCTCTCTGCGTTCTATCTTCTCTCTCCTCCTTGTTCCTGCAAACCACAAGATAAAGGTAGTGGTGTGTCTCGAC CCCATCAGCCTCTCACCCACTCCCAGACACACACAAGTCCTCAAAAGTTTCAGCTCCGTGTGTGAGATGTGCAGGTTTTTTCTAGGGGGT AGGGGGAGACTAAAATCGAATATAACTTAAAATGAAAGTATACTTTTTATAATTTTTCTTTTTAAAACTTGGTGAAATTATTTCAGATAC ATATTTTAGTGTCAAGGCAGATTAGTTATTTAGCCACCAAAAAAAAGTATTGTGTACAATTTGGGGCCTCAAATTTGACTCTGCCTCAAA 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FusionGenePPI for DDX52_STAT5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDX52 | MYC, SIRT7, COPS5, CAND1, PAXIP1, MMS19, HLCS, PMP22, AP4M1, OBSL1, EED, RNF2, RPL14, ZNF22, AATF, DIMT1, ESF1, KRR1, MPHOSPH10, NOC2L, IMP4, KIAA0020, NOC4L, NOL10, RSL1D1, IFI16, FOXL1, FOXL2, FOXM1, HIST1H1T, CCDC59, RPL18, ZNF324B, GPATCH4, FGF3, RRP8, RSBN1, UTP23, MTNR1A, FOXA1 | STAT5B | IL2RB, JAK2, PTPN11, JAK1, JAK3, ELP2, NR3C1, SHC1, NMI, GHR, CD247, CCR5, EGFR, PTPN1, PTPN6, POU2F1, FGFR2, PGR, STAT5B, PRLR, APP, C18orf8, VCAM1, INSR, HAX1, IL15, TFG, SERTAD1, AFTPH, DMRTA1, AARS, ANKMY2, NIF3L1, RPRD1A, DPP9, RPRD1B, SURF2, TOM1L1, KIT, MCMBP, ALAD, NTRK1, DLAT, DLD, HIVEP1, PDHA1, PDHB, PDHX, MVP, KANSL3, ASF1B, PUS7L, CTLA4, STAT3, STAT5A, ADAM32, C9orf156, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDX52_STAT5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | STAT5B | P51692 | DB01254 | Dasatinib | Signal transducer and activator of transcription 5B | small molecule | approved|investigational |
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RelatedDiseases for DDX52_STAT5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | STAT5B | C1855548 | Laron syndrome type 2 | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | STAT5B | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Tgene | STAT5B | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Tgene | STAT5B | C1522378 | Leukemia, Large Granular Lymphocytic | 1 | CTD_human |
| Tgene | STAT5B | C2931322 | T-Lymphocytopenia | 1 | CTD_human |
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