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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9609

FusionGeneSummary for DDX39B_UBTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX39B_UBTD1
Fusion gene ID: 9609
HgeneTgene
Gene symbol

DDX39B

UBTD1

Gene ID

7919

80019

Gene nameDExD-box helicase 39Bubiquitin domain containing 1
SynonymsBAT1|D6S81E|UAP56-
Cytomap

6p21.33

10q24.1-q24.2

Type of geneprotein-codingprotein-coding
Descriptionspliceosome RNA helicase DDX39B56 kDa U2AF65-associated proteinATP-dependent RNA helicase p47DEAD (Asp-Glu-Ala-Asp) box polypeptide 39BDEAD-box helicase 39BHLA-B-associated transcript 1 proteinnuclear RNA helicase (DEAD family)spliceosome RNA helicubiquitin domain-containing protein 1
Modification date2018052220180522
UniProtAcc

Q13838

Q9HAC8

Ensembl transtripts involved in fusion geneENST00000376177, ENST00000396172, 
ENST00000417556, ENST00000458640, 
ENST00000462421, ENST00000415382, 
ENST00000453105, ENST00000449074, 
ENST00000552820, ENST00000463430, 
ENST00000438578, ENST00000415689, 
ENST00000456476, ENST00000412106, 
ENST00000547039, ENST00000550435, 
ENST00000453488, ENST00000453138, 
ENST00000552288, ENST00000441425, 
ENST00000456666, ENST00000546633, 
ENST00000483957, ENST00000430703, 
ENST00000416863, ENST00000413678, 
ENST00000414440, ENST00000547489, 
ENST00000551031, ENST00000468089, 
ENST00000400293, ENST00000400296, 
ENST00000400295, ENST00000383508, 
ENST00000548340, ENST00000548331, 
ENST00000495391, ENST00000446341, 
ENST00000548614, ENST00000448296, 
ENST00000412330, ENST00000445218, 
ENST00000546637, ENST00000489325, 
ENST00000450987, ENST00000431360, 
ENST00000430784, ENST00000550217, 
ENST00000470514, ENST00000549374, 
ENST00000370664, 
Fusion gene scores* DoF score10 X 7 X 6=4204 X 3 X 2=24
# samples 103
** MAII scorelog2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DDX39B [Title/Abstract] AND UBTD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX39B

GO:0000245

spliceosomal complex assembly

18593880

HgeneDDX39B

GO:0006406

mRNA export from nucleus

17190602

HgeneDDX39B

GO:0008380

RNA splicing

18593880

HgeneDDX39B

GO:0010501

RNA secondary structure unwinding

18593880

HgeneDDX39B

GO:0046784

viral mRNA export from host cell nucleus

18974867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA642571DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000376177ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000396172ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000417556ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000458640ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000462421ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000415382ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000453105ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000449074ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000552820ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000463430ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000438578ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000415689ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000456476ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000412106ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000547039ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000550435ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000453488ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000453138ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000552288ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000441425ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000456666ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000546633ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000483957ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000430703ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000416863ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000413678ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000414440ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000547489ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000551031ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000468089ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000400293ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000400296ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000400295ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000383508ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000548340ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000548331ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000495391ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000446341ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000548614ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000448296ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000412330ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000445218ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000546637ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000489325ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000450987ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000431360ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000430784ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000550217ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000470514ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-
intron-3UTRENST00000549374ENST00000370664DDX39Bchr6

2828922

+UBTD1chr10

99330334

-

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FusionProtFeatures for DDX39B_UBTD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX39B

Q13838

UBTD1

Q9HAC8

May be involved in the regulation of cellular senescencethrough a positive feedback loop with TP53. Is a TP53 downstreamtarget gene that increases the stability of TP53 protein bypromoting the ubiquitination and degradation of MDM2.{ECO:0000269|PubMed:25382750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDX39B_UBTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDX39B_UBTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDX39B_UBTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDDX39BQ13838DB02325Isopropyl AlcoholSpliceosome RNA helicase DDX39Bsmall moleculeapproved|investigational
HgeneDDX39BQ13838DB11638ArtenimolSpliceosome RNA helicase DDX39Bsmall moleculeapproved|investigational

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RelatedDiseases for DDX39B_UBTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource