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Fusion gene ID: 9575 |
FusionGeneSummary for DDX1_RPL28 |
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Fusion gene information | Fusion gene name: DDX1_RPL28 | Fusion gene ID: 9575 | Hgene | Tgene | Gene symbol | DDX1 | RPL28 | Gene ID | 1653 | 6158 |
Gene name | DEAD-box helicase 1 | ribosomal protein L28 | |
Synonyms | DBP-RB|UKVH5d | L28 | |
Cytomap | 2p24.3 | 19q13.42 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-dependent RNA helicase DDX1DEAD (Asp-Glu-Ala-Asp) box helicase 1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1DEAD box polypeptide 1DEAD box protein 1DEAD box protein retinoblastomaDEAD box-1DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1DEAD/H-box h | 60S ribosomal protein L28large ribosomal subunit protein eL28 | |
Modification date | 20180522 | 20180525 | |
UniProtAcc | Q92499 | P46779 | |
Ensembl transtripts involved in fusion gene | ENST00000381341, ENST00000233084, | ENST00000344063, ENST00000431533, ENST00000428193, ENST00000558815, ENST00000560583, ENST00000560055, ENST00000559463, ENST00000558131, ENST00000558752, ENST00000458349, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 8 X 4=256 |
# samples | 2 | 11 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/256*10)=-1.21864028647534 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DDX1 [Title/Abstract] AND RPL28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDX1 | GO:0006302 | double-strand break repair | 18710941 |
Hgene | DDX1 | GO:0032508 | DNA duplex unwinding | 18710941 |
Hgene | DDX1 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 18710941 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG473709 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000381341 | ENST00000344063 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000381341 | ENST00000431533 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000381341 | ENST00000428193 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000381341 | ENST00000558815 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000381341 | ENST00000560583 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000381341 | ENST00000560055 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000381341 | ENST00000559463 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000381341 | ENST00000558131 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000381341 | ENST00000558752 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000381341 | ENST00000458349 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000344063 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000431533 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000428193 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000558815 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000560583 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-5UTR | ENST00000233084 | ENST00000560055 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000233084 | ENST00000559463 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000233084 | ENST00000558131 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000233084 | ENST00000558752 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
5CDS-intron | ENST00000233084 | ENST00000458349 | DDX1 | chr2 | 15760492 | - | RPL28 | chr19 | 55897300 | + |
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FusionProtFeatures for DDX1_RPL28 |
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Hgene | Tgene |
DDX1 | RPL28 |
Acts as an ATP-dependent RNA helicase, able to unwindboth RNA-RNA and RNA-DNA duplexes. Possesses 5' single-strandedRNA overhang nuclease activity. Possesses ATPase activity onvarious RNA, but not DNA polynucleotides. May play a role in RNAclearance at DNA double-strand breaks (DSBs), thereby facilitatingthe template-guided repair of transcriptionally active regions ofthe genome. Together with RELA, acts as a coactivator to enhanceNF-kappa-B-mediated transcriptional activation. Acts as a positivetranscriptional regulator of cyclin CCND2 expression. Binds to thecyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds topoly(A) RNA. May be involved in 3'-end cleavage andpolyadenylation of pre-mRNAs. Component of the tRNA-splicingligase complex required to facilitate the enzymatic turnover ofcatalytic subunit RTCB: together with archease (ZBTB8OS), acts byfacilitating the guanylylation of RTCB, a key intermediate step intRNA ligation (PubMed:24870230). {ECO:0000269|PubMed:12183465,ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541,ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827,ECO:0000269|PubMed:24870230}. (Microbial infection) Required for HIV-1 Rev function aswell as for HIV-1 and coronavirus IBV replication. Binds to theRRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}. (Microbial infection) Required for Coronavirus IBVreplication. {ECO:0000269|PubMed:20573827}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDX1_RPL28 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DDX1_RPL28 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDX1_RPL28 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDX1_RPL28 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DDX1 | C0014173 | Endometrial Hyperplasia | 1 | CTD_human |
Hgene | DDX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | RPL28 | C0043094 | Weight Gain | 1 | CTD_human |