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Fusion gene ID: 9552 |
FusionGeneSummary for DDX10_OTUD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX10_OTUD4 | Fusion gene ID: 9552 | Hgene | Tgene | Gene symbol | DDX10 | OTUD4 | Gene ID | 1662 | 54726 |
| Gene name | DEAD-box helicase 10 | OTU deubiquitinase 4 | |
| Synonyms | Dbp4|HRH-J8 | DUBA6|HIN1|HSHIN1 | |
| Cytomap | 11q22.3 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX10DDX10-NUP98 fusion protein type 2DEAD (Asp-Glu-Ala-Asp) box polypeptide 10DEAD box protein 10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase) | OTU domain-containing protein 4HIV-1 induced protein HIN-1 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q13206 | Q01804 | |
| Ensembl transtripts involved in fusion gene | ENST00000322536, ENST00000526794, ENST00000534221, | ENST00000455611, ENST00000454497, ENST00000447906, ENST00000509620, ENST00000296579, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DDX10 [Title/Abstract] AND OTUD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | OTUD4 | GO:0034122 | negative regulation of toll-like receptor signaling pathway | 29395066 |
| Tgene | OTUD4 | GO:0070536 | protein K63-linked deubiquitination | 29395066 |
| Tgene | OTUD4 | GO:0071108 | protein K48-linked deubiquitination | 23827681 |
| Tgene | OTUD4 | GO:1901537 | positive regulation of DNA demethylation | 25944111 |
| Tgene | OTUD4 | GO:1903093 | regulation of protein K48-linked deubiquitination | 25944111 |
| Tgene | OTUD4 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 29395066 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A8IF-01A | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000322536 | ENST00000455611 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000322536 | ENST00000454497 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000322536 | ENST00000447906 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000322536 | ENST00000509620 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000322536 | ENST00000296579 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-5UTR | ENST00000526794 | ENST00000455611 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000526794 | ENST00000454497 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000526794 | ENST00000447906 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000526794 | ENST00000509620 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| 5CDS-intron | ENST00000526794 | ENST00000296579 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| intron-5UTR | ENST00000534221 | ENST00000455611 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| intron-intron | ENST00000534221 | ENST00000454497 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| intron-intron | ENST00000534221 | ENST00000447906 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| intron-intron | ENST00000534221 | ENST00000509620 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
| intron-intron | ENST00000534221 | ENST00000296579 | DDX10 | chr11 | 108577564 | + | OTUD4 | chr4 | 146032280 | - |
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FusionProtFeatures for DDX10_OTUD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX10 | OTUD4 |
| Putative ATP-dependent RNA helicase. | Deubiquitinase which hydrolyzes the isopeptide bondbetween the ubiquitin C-terminus and the lysine epsilon-aminogroup of the target protein (PubMed:23827681, PubMed:25944111,PubMed:29395066). May negatively regulate inflammatory andpathogen recognition signaling in innate immune response. Uponphosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptorand Toll-like receptor signaling pathway, specificallydeubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter proteintriggering down-regulation of NF-kappa-B-dependent transcriptionof inflammatory mediators (PubMed:29395066). Independently of thecatalytic activity, acts as a scaffold for alternativedeubiquitinases to assemble specific deubiquitinase-substratecomplexes. Associates with USP7 and USP9X deubiquitinases tostabilize alkylation repair enzyme ALKBH3, thereby promoting therepair of alkylated DNA lesions (PubMed:25944111).{ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111,ECO:0000269|PubMed:29395066}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDX10_OTUD4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DDX10_OTUD4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDX10 | G3BP2, SIRT7, CAND1, APP, OBSL1, NOL12, BYSL, SRFBP1, NTRK1, CKB, DDX56, KIAA0020, DDX54, PWP1, IFI16, EED, NOP56, ZNF2, RBM34, RPL18, DGCR8, RPL18A, CDX1, WDR46, FGF8, HIST1H1E, HIST1H1T, RPL30, ZC3HAV1, GLTSCR2, RPL37A, TRIM25 | OTUD4 | ATG12, ILK, RUNX1T1, CLEC3B, BRF2, DSG1, FLNC, GALK1, GLA, DNAJB1, KRT8, KRT31, KRT33B, KRT85, MOG, OAT, TUBA1A, KRT36, FXR2, NPEPPS, BAG5, GPHN, MYCBP, NMD3, PARP11, RPTN, AGO3, GRK5, FMNL1, UBC, REL, STAT1, TCF4, EXOSC8, WBP2NL, RBFOX2, LHX6, XPO1, HIST1H3E, HSF2, PRPF4, GAR1, NAF1, ALKBH3, ALKBH2, USP7, USP9X, TRAF1, RC3H1, DUSP10, FAN1, TPTE2, VTN, HTRA4, C4orf26, KIAA1683, TSPYL6, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDX10_OTUD4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDX10_OTUD4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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