![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 9500 |
FusionGeneSummary for DDB1_CPSF7 |
![]() |
Fusion gene information | Fusion gene name: DDB1_CPSF7 | Fusion gene ID: 9500 | Hgene | Tgene | Gene symbol | DDB1 | CPSF7 | Gene ID | 1642 | 79869 |
Gene name | damage specific DNA binding protein 1 | cleavage and polyadenylation specific factor 7 | |
Synonyms | DDBA|UV-DDB1|XAP1|XPCE|XPE|XPE-BF | CFIm59 | |
Cytomap | 11q12.2 | 11q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA damage-binding protein 1DDB p127 subunitDNA damage-binding protein aHBV X-associated protein 1UV-DDB 1UV-damaged DNA-binding factorUV-damaged DNA-binding protein 1XAP-1XPE-binding factordamage-specific DNA binding protein 1, 127kDaxeroderma | cleavage and polyadenylation specificity factor subunit 7CPSF 59 kDa subunitcleavage and polyadenylation specificity factor 59 kDa subunitcleavage factor Im complex 59 kDa subunitpre-mRNA cleavage factor I, 59 kDa subunitpre-mRNA cleavage factor Im 5 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q16531 | Q8N684 | |
Ensembl transtripts involved in fusion gene | ENST00000301764, ENST00000450997, ENST00000451943, ENST00000538470, ENST00000545930, | ENST00000340437, ENST00000394888, ENST00000439958, ENST00000494016, ENST00000448745, ENST00000541963, | |
Fusion gene scores | * DoF score | 12 X 12 X 6=864 | 5 X 5 X 4=100 |
# samples | 14 | 6 | |
** MAII score | log2(14/864*10)=-2.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DDB1 [Title/Abstract] AND CPSF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDB1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11673459 |
Hgene | DDB1 | GO:0035518 | histone H2A monoubiquitination | 22334663 |
Hgene | DDB1 | GO:0051702 | interaction with symbiont | 23137809 |
Hgene | DDB1 | GO:0070914 | UV-damage excision repair | 22334663 |
Tgene | CPSF7 | GO:0051262 | protein tetramerization | 20695905 |
Tgene | CPSF7 | GO:0051290 | protein heterotetramerization | 23187700 |
Tgene | CPSF7 | GO:1990120 | messenger ribonucleoprotein complex assembly | 29276085 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ESCA | TCGA-L5-A8NI-01A | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
TCGA | RV | LIHC | TCGA-BC-A10Y-01A | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000301764 | ENST00000340437 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
Frame-shift | ENST00000301764 | ENST00000394888 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
Frame-shift | ENST00000301764 | ENST00000439958 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
5CDS-intron | ENST00000301764 | ENST00000494016 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
5CDS-intron | ENST00000301764 | ENST00000448745 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
5CDS-intron | ENST00000301764 | ENST00000541963 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000450997 | ENST00000340437 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000450997 | ENST00000394888 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000450997 | ENST00000439958 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000450997 | ENST00000494016 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000450997 | ENST00000448745 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000450997 | ENST00000541963 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000451943 | ENST00000340437 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000451943 | ENST00000394888 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000451943 | ENST00000439958 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000451943 | ENST00000494016 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000451943 | ENST00000448745 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000451943 | ENST00000541963 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000538470 | ENST00000340437 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000538470 | ENST00000394888 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000538470 | ENST00000439958 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000538470 | ENST00000494016 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000538470 | ENST00000448745 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000538470 | ENST00000541963 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000545930 | ENST00000340437 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000545930 | ENST00000394888 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-3CDS | ENST00000545930 | ENST00000439958 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000545930 | ENST00000494016 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000545930 | ENST00000448745 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
intron-intron | ENST00000545930 | ENST00000541963 | DDB1 | chr11 | 61080971 | - | CPSF7 | chr11 | 61183991 | - |
In-frame | ENST00000301764 | ENST00000340437 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
In-frame | ENST00000301764 | ENST00000394888 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
In-frame | ENST00000301764 | ENST00000439958 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000301764 | ENST00000494016 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000301764 | ENST00000448745 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000301764 | ENST00000541963 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
In-frame | ENST00000450997 | ENST00000340437 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
In-frame | ENST00000450997 | ENST00000394888 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
In-frame | ENST00000450997 | ENST00000439958 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000450997 | ENST00000494016 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000450997 | ENST00000448745 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
5CDS-intron | ENST00000450997 | ENST00000541963 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000451943 | ENST00000340437 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000451943 | ENST00000394888 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000451943 | ENST00000439958 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000451943 | ENST00000494016 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000451943 | ENST00000448745 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000451943 | ENST00000541963 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000538470 | ENST00000340437 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000538470 | ENST00000394888 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000538470 | ENST00000439958 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000538470 | ENST00000494016 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000538470 | ENST00000448745 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000538470 | ENST00000541963 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000545930 | ENST00000340437 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000545930 | ENST00000394888 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-3CDS | ENST00000545930 | ENST00000439958 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000545930 | ENST00000494016 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000545930 | ENST00000448745 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
intron-intron | ENST00000545930 | ENST00000541963 | DDB1 | chr11 | 61099015 | - | CPSF7 | chr11 | 61189080 | - |
Top |
FusionProtFeatures for DDB1_CPSF7 |
![]() |
Hgene | Tgene |
DDB1 | CPSF7 |
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruitproteins of the nucleotide excision repair pathway (the NERpathway) to initiate DNA repair. The UV-DDB complex preferentiallybinds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts(6-4 PP), apurinic sites and short mismatches. Also appears tofunction as a component of numerous distinct DCX (DDB1-CUL4-X-box)E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of targetproteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substraterecognition component recruited by DDB1. DCX(DDB2) (also known asDDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinatehistone H2A, histone H3 and histone H4 at sites of UV-induced DNAdamage. The ubiquitination of histones may facilitate theirremoval from the nucleosome and promote subsequent DNA repair.DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding byXPC and promote NER. DCX(DTL) plays a role in PCNA-dependentpolyubiquitination of CDT1 and MDM2-dependent ubiquitination ofTP53 in response to radiation-induced DNA damage and during DNAreplication. DCX(ERCC8) (the CSA complex) plays a role intranscription-coupled repair (TCR). May also play a role inubiquitination of CDKN1B/p27kip when associated with CUL4 andSKP2. {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464,ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621,ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242,ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935,ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110,ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588,ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868,ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899,ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460,ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355}. | Component of the cleavage factor Im (CFIm) complex thatfunctions as an activator of the pre-mRNA 3'-end cleavage andpolyadenylation processing required for the maturation of pre-mRNAinto functional mRNAs (PubMed:8626397, PubMed:17024186,PubMed:29276085). CFIm contributes to the recruitment ofmultiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals)(PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiplepA signals, resulting in alternative cleavage and polyadenylation(APA) producing mRNAs with variable 3'-end formation(PubMed:23187700, PubMed:29276085). The CFIm complex acts as a keyregulator of cleavage and polyadenylation site choice during APAthrough its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs(PubMed:20695905, PubMed:29276085). CPSF7 activates directly themRNA 3'-processing machinery (PubMed:29276085). Binds to pAsignals in RNA substrates (PubMed:8626397, PubMed:17024186).{ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905,ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085,ECO:0000269|PubMed:8626397}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000340437 | - | 1 | 10 | 218_329 | 61 | 1168 | Compositional bias | Note=Pro-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000340437 | - | 1 | 10 | 418_469 | 61 | 1168 | Compositional bias | Note=Arg-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000394888 | - | 1 | 10 | 218_329 | 18 | 1137 | Compositional bias | Note=Pro-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000394888 | - | 1 | 10 | 418_469 | 18 | 1137 | Compositional bias | Note=Arg-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000394888 | - | 1 | 10 | 51_54 | 18 | 1137 | Compositional bias | Note=Poly-Pro |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000439958 | - | 1 | 10 | 218_329 | 18 | 1107 | Compositional bias | Note=Pro-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000439958 | - | 1 | 10 | 418_469 | 18 | 1107 | Compositional bias | Note=Arg-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000439958 | - | 1 | 10 | 51_54 | 18 | 1107 | Compositional bias | Note=Poly-Pro |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000448745 | - | 0 | 9 | 218_329 | 18 | 500 | Compositional bias | Note=Pro-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000448745 | - | 0 | 9 | 418_469 | 18 | 500 | Compositional bias | Note=Arg-rich |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000448745 | - | 0 | 9 | 51_54 | 18 | 500 | Compositional bias | Note=Poly-Pro |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000340437 | - | 1 | 10 | 82_162 | 61 | 1168 | Domain | RRM |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000394888 | - | 1 | 10 | 82_162 | 18 | 1137 | Domain | RRM |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000439958 | - | 1 | 10 | 82_162 | 18 | 1107 | Domain | RRM |
Tgene | >CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000448745 | - | 0 | 9 | 82_162 | 18 | 500 | Domain | RRM |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DDB1 | chr11:61099015 | chr11:61189080 | ENST00000301764 | - | 2 | 27 | 13_356 | 70 | 1141 | Region | Note=WD repeat beta-propeller A |
Hgene | >DDB1 | chr11:61099015 | chr11:61189080 | ENST00000301764 | - | 2 | 27 | 709_1043 | 70 | 1141 | Region | Note=WD repeat beta-propeller C |
Tgene | CPSF7 | chr11:61099015 | chr11:61189080 | ENST00000340437 | - | 1 | 10 | 51_54 | 61 | 1168 | Compositional bias | Note=Poly-Pro |
Top |
FusionGeneSequence for DDB1_CPSF7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for DDB1_CPSF7 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DDB1 | DET1, RFWD2, DDB2, SUPT3H, KAT2A, CDKN1A, CUL4A, CUL4B, FBXW5, NF2, POLR2J, GPN1, PMS2, UBC, PCNA, TRPC4AP, DDA1, NEDD8, CRBN, COPS3, COPS4, COPS5, COPS2, COPS8, COPS7B, COPS7A, COPS6, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, DCAF8, ERCC8, VPRBP, DTL, AMBRA1, DCAF7, DCAF13, DCAF15, DCAF16, DCAF17, GPS1, RBX1, SKP2, TOR1AIP2, BANF1, XPC, HOXD3, CNOT2, MAFB, ZNF277, EED, RBBP5, HIST1H3A, CAND1, CDT1, CDKN1B, CENPA, CHEK1, TADA2A, TERF1, TERF2, SETD8, ERCC6, SNW1, UNG, HDAC5, UBXN7, FAF2, UBXN1, DYRK2, UBR5, KATNA1, MYC, RASSF1, RAG1, RAG2, CTNNB1, AHR, PIDD1, SALL2, RAD21, UBA1, HOXB4, MCM10, RECQL, SIRT7, SAMHD1, EP300, UBE2E3, POLR2A, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, GRWD1, CUL3, CUL5, CUL1, DCUN1D1, SLX4, DCLRE1C, MYB, PTPN14, LRWD1, MDM2, KCND3, FZR1, E2F1, ABL1, RORA, XPA, GRK5, GRK6, SHC1, TP73, SRSF9, TCERG1, TAF15, PUF60, RPS7, STRIP1, NUP133, TPR, NUMA1, STRN4, TPM2, FLNC, ATP6V1F, NCOA5, CSTF2, RANBP9, VTN, NXF1, SAP30BP, MBD3, RTN4, RPTOR, MTOR, RICTOR, UCHL1, TERT, DDB1, INO80, ACTR5, ALB, DDIT4, INVS, NPHP4, LMO4, UVSSA, STAT1, MEF2A, DYRK1B, TOPBP1, MIB1, DLC1, PIN1, VASP, RPA3, RPA2, RPA1, NR1I2, ASB4, NR2C2, FTSJ3, AURKA, AURKB, CEP250, CEP57, CEP72, TP53, TUBGCP2, HDAC1, HDAC2, SIN3A, ARID4B, SAP130, SUDS3, SAP30, RBP1, HUWE1, IP6K1, BRCA1, HIST1H1A, HIST1H1C, CUL7, OBSL1, SIRT6, CLCN1, EPB41L3, RASSF9, RASSF10, RPS6KB2, BECN1, TRAF6, TET2, TET1, TET3, CORO1B, ACAT1, APEX1, CGGBP1, CLIC1, CLIC4, CMAS, LASP1, MCM5, NHP2L1, PSMA1, SNX2, YARS, LSM2, SF3A3, NTRK1, FBXO44, RGS2, PTEN, EWSR1, CAMKK1, PYGO2, HDAC3, HDAC8, CRY2, GNB2, RBBP7, CDC5L, PCGF1, DPPA4, BCOR, NANOG, POU5F1, DCUN1D5, UVRAG, MYO6, MOAP1, DERL1, ZNF746, CCNG1, CYLD, TRIM25, CEP78, CCP110, DCAF4L2, MUS81, EME1, XRCC5, RNF169 | CPSF7 | NUDT21, DVL2, GCC1, SORBS3, PRMT2, EWSR1, NCK2, CLP1, TSG101, ATXN1, SMAD2, HNRNPA1, CPSF6, UBAP2L, TPM2, NDUFS2, MCM2, MRPS31, NUP133, RPS19, OGDH, ERGIC3, FN1, VCAM1, CSNK2A1, DAB2, ITGA4, ITCH, WBP4, APBB1, WWOX, RPA3, RPA2, RPA1, FXR2, STAU1, AES, RUNX1T1, CLK2, SMAD3, EPM2AIP1, SEC23B, SNRNP25, ARMC7, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, EZH2, SUZ12, EED, FAM192A, LUC7L, FAM58A, KHSRP, NTRK1, MED4, MED20, MED23, SRPK2, B9D2, WWP2, CLTC, GAK, PFKFB2, SEC16A, RNPS1, CCDC93, ZNF766, BRINP1, SNW1, CDC5L, JMJD6, DDX20, BCHE, PDHA1, SOD1, FOXA1, G3BP1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | DDB1 | chr11:61099015 | chr11:61189080 | ENST00000301764 | - | 2 | 27 | 771_1140 | 70 | 1141 | CDT1 and CUL4A |
Hgene | DDB1 | chr11:61099015 | chr11:61189080 | ENST00000301764 | - | 2 | 27 | 2_768 | 70 | 1141 | CDT1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DDB1_CPSF7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DDB1_CPSF7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DDB1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |