![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 95 |
FusionGeneSummary for ABCA1_HNRNPK |
![]() |
Fusion gene information | Fusion gene name: ABCA1_HNRNPK | Fusion gene ID: 95 | Hgene | Tgene | Gene symbol | ABCA1 | HNRNPK | Gene ID | 19 | 3190 |
Gene name | ATP binding cassette subfamily A member 1 | heterogeneous nuclear ribonucleoprotein K | |
Synonyms | ABC-1|ABC1|CERP|HDLDT1|TGD | AUKS|CSBP|HNRPK|TUNP | |
Cytomap | 9q31.1 | 9q21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-binding cassette sub-family A member 1ATP-binding cassette transporter A1ATP-binding cassette, sub-family A (ABC1), member 1cholesterol efflux regulatory proteinmembrane-bound | heterogeneous nuclear ribonucleoprotein KdC-stretch binding proteintransformation upregulated nuclear protein | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | O95477 | P61978 | |
Ensembl transtripts involved in fusion gene | ENST00000374736, ENST00000494467, ENST00000423487, ENST00000374733, | ENST00000376281, ENST00000376263, ENST00000376264, ENST00000351839, ENST00000360384, | |
Fusion gene scores | * DoF score | 11 X 7 X 7=539 | 4 X 4 X 2=32 |
# samples | 10 | 4 | |
** MAII score | log2(10/539*10)=-2.43028527297778 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ABCA1 [Title/Abstract] AND HNRNPK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABCA1 | GO:0007040 | lysosome organization | 15163665 |
Hgene | ABCA1 | GO:0008203 | cholesterol metabolic process | 14747463 |
Hgene | ABCA1 | GO:0016197 | endosomal transport | 14747463 |
Hgene | ABCA1 | GO:0033344 | cholesterol efflux | 10431236|11162594|23931754 |
Hgene | ABCA1 | GO:0033700 | phospholipid efflux | 10431236|11162594 |
Hgene | ABCA1 | GO:0042632 | cholesterol homeostasis | 10431236 |
Hgene | ABCA1 | GO:0045332 | phospholipid translocation | 24097981 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CR983438 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000374736 | ENST00000376281 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374736 | ENST00000376263 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374736 | ENST00000376264 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374736 | ENST00000351839 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374736 | ENST00000360384 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
intron-5UTR | ENST00000494467 | ENST00000376281 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
intron-5UTR | ENST00000494467 | ENST00000376263 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
intron-5UTR | ENST00000494467 | ENST00000376264 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
intron-5UTR | ENST00000494467 | ENST00000351839 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
intron-5UTR | ENST00000494467 | ENST00000360384 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000423487 | ENST00000376281 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000423487 | ENST00000376263 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000423487 | ENST00000376264 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000423487 | ENST00000351839 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000423487 | ENST00000360384 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374733 | ENST00000376281 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374733 | ENST00000376263 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374733 | ENST00000376264 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374733 | ENST00000351839 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
5UTR-5UTR | ENST00000374733 | ENST00000360384 | ABCA1 | chr9 | 107690215 | - | HNRNPK | chr9 | 86593369 | - |
Top |
FusionProtFeatures for ABCA1_HNRNPK |
![]() |
Hgene | Tgene |
ABCA1 | HNRNPK |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ABCA1_HNRNPK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ABCA1_HNRNPK |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ABCA1 | FADD, APOA1, SNTB2, UGP2, SDHB, AOX1, PRPF8, HGS, COPS5, COPS2, CSNK2A2, STX12, FLOT1, CDC42, LNX1, ATXN10, SPTLC1, ERBB2IP, TGM2, IKBKG, FUS, RELA, NR1H2, EGFR | HNRNPK | RBM41, CNNM3, GRAP2, HNRNPK, MATR3, RBM42, RBM7, NPDC1, KHDRBS3, KHDRBS2, RBMX, QKI, SORBS3, UBE2I, NCK2, DIDO1, PRMT1, DDX1, PCBP2, PTBP1, HNRNPL, CSK, VAV1, CEBPB, HMGB1, KHDRBS1, ITK, MEPCE, CDK9, HNRNPA1, HNRNPH1, TCEA2, GRB2, H3F3A, EMD, MORF4L1, MORF4L2, MRGBP, UBC, MYC, POU5F1, PABPC1, TOP1, VHL, SMARCAD1, SREK1, SIRT1, MBNL1, ITSN2, SF3A2, ARRB1, ARRB2, SH3KBP1, ISG15, TERF2IP, CBX4, MDM2, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, EIF3F, RNA28S5, RNA18S5, GFI1B, PCBP1, LRRK1, CBLB, SF3B3, HNRNPU, YBX1, SF3B1, HNRNPR, HNRNPA3, SRSF1, HNRNPF, EFTUD2, SNRPD1, SF3A1, HNRNPM, U2AF2, NHP2L1, SNRNP70, SRSF11, ILF3, SYNCRIP, EEF1A1, HNRNPA0, SRRM2, TARDBP, DHX15, SUPT5H, RANBP2, GTF3C4, TNKS1BP1, TPM4, SART3, USP14, IDH3G, GAA, RAB7A, NXF1, HSPA4, RPS7, SPTAN1, RCC1, CAMK2A, MRPL23, ESR1, MAGOH, EIF4A3, TP53, SUMO1, PIAS3, SENP2, SMURF1, GZMK, GZMA, PPP1R10, FN1, VCAM1, SNRPA, CCAR1, RBM10, SF1, ELAVL1, SRRT, RALY, CTNNBL1, DDX17, DDX5, DHX9, CIRBP, RBM4, HNRNPD, RBFOX2, TP63, UBL4A, ITGA4, CTNNB1, CD81, IGSF8, ICAM1, LYN, ADRB2, BAG3, BTRC, SMAD3, PELI2, CDKN1A, YWHAQ, FBXO6, PARK2, TCERG1, PRPF40A, WBP4, APBB1, NEDD4, PIN1, WWOX, APEX1, EIF5, FERMT2, UBFD1, XPO1, YWHAH, NAPRT, NCL, RPA1, RPA2, RPA3, ASB2, LGR4, IVNS1ABP, STAU1, HUWE1, FUS, AQP5, DOCK2, RBM3, RBMY1A1, SPG7, TYK2, U2AF1, ABI2, PRPF31, RASD1, DALRD3, PCDHB14, MARK4, FBXL18, CCDC33, PRR3, YTHDC1, HNRNPLL, ZNF792, RBMY1F, ZFC3H1, ZNF385C, RTP5, C6orf226, ZNRF2P1, HIST3H3, CUL7, OBSL1, EED, PA2G4, SUMO2, SIRT6, RPS6KB2, CARM1, ACLY, EEF1D, ELAC2, HGS, PKM, RPS5, TUBA4A, UQCRC2, NPLOC4, PDIA3, SEPT2, VCP, XRCC6, NTRK1, SCARNA22, SRPK2, CMTM5, HIST1H3E, AHSA1, HNRNPH2, SEC16A, CRY1, CRY2, MCM2, SNW1, CDC5L, RC3H1, SRC, AURKA, CDC73, CRBN, WWP2, CDH1, EGFR, SNX33, FNBP1L, CASP2, KLHL23, TRMT1L, SNX9, PRMT8, TRMT61B, PLCG1, YARS2, CYLD, HEY1, BRCA1, LMNA, DCAF4L2, FBXW7, HDAC6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ABCA1_HNRNPK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ABCA1 | O95477 | DB01016 | Glyburide | ATP-binding cassette sub-family A member 1 | small molecule | approved |
Hgene | ABCA1 | O95477 | DB01599 | Probucol | ATP-binding cassette sub-family A member 1 | small molecule | approved|investigational |
Tgene | HNRNPK | P61978 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein K | small molecule | approved|investigational |
Top |
RelatedDiseases for ABCA1_HNRNPK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCA1 | C0039292 | Tangier Disease | 19 | CTD_human;ORPHANET;UNIPROT |
Hgene | ABCA1 | C1704429 | Hypoalphalipoproteinemia, Familial | 4 | ORPHANET;UNIPROT |
Hgene | ABCA1 | C2931838 | Familial HDL deficiency | 2 | CTD_human |
Hgene | ABCA1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | ABCA1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ABCA1 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
Hgene | ABCA1 | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
Hgene | ABCA1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | ABCA1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | ABCA1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | HNRNPK | C1458155 | Mammary Neoplasms | 1 | CTD_human |