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Fusion gene ID: 9494 |
FusionGeneSummary for DDAH1_ZNHIT6 |
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Fusion gene information | Fusion gene name: DDAH1_ZNHIT6 | Fusion gene ID: 9494 | Hgene | Tgene | Gene symbol | DDAH1 | ZNHIT6 | Gene ID | 23576 | 54680 |
Gene name | dimethylarginine dimethylaminohydrolase 1 | zinc finger HIT-type containing 6 | |
Synonyms | DDAH|DDAH-1|DDAHI|HEL-S-16 | BCD1|C1orf181|NY-BR-75 | |
Cytomap | 1p22.3 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1NG, NG-dimethylarginine dimethylaminohydrolasedimethylargininase-1epididymis secretory protein Li 16 | box C/D snoRNA protein 1box C/D snoRNA essential 1 homologserologically defined breast cancer antigen NY-BR-75zinc finger HIT domain-containing protein 6zinc finger, HIT type 6 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O94760 | Q9NWK9 | |
Ensembl transtripts involved in fusion gene | ENST00000535924, ENST00000483110, ENST00000284031, ENST00000539042, ENST00000426972, ENST00000542148, | ENST00000431532, ENST00000370574, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 3=48 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DDAH1 [Title/Abstract] AND ZNHIT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDAH1 | GO:0000052 | citrulline metabolic process | 19663506 |
Hgene | DDAH1 | GO:0006527 | arginine catabolic process | 24895913 |
Hgene | DDAH1 | GO:0008285 | negative regulation of cell proliferation | 24895913 |
Hgene | DDAH1 | GO:0043116 | negative regulation of vascular permeability | 24895913 |
Hgene | DDAH1 | GO:1900038 | negative regulation of cellular response to hypoxia | 24895913 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AC-A6IW-01A | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000535924 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000535924 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000483110 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000483110 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
Frame-shift | ENST00000284031 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
Frame-shift | ENST00000284031 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
Frame-shift | ENST00000539042 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
Frame-shift | ENST00000539042 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000426972 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000426972 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000542148 | ENST00000431532 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
intron-3CDS | ENST00000542148 | ENST00000370574 | DDAH1 | chr1 | 85930426 | - | ZNHIT6 | chr1 | 86119781 | - |
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FusionProtFeatures for DDAH1_ZNHIT6 |
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Hgene | Tgene |
DDAH1 | ZNHIT6 |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) andN(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.Has therefore a role in the regulation of nitric oxide generation. | Required for box C/D snoRNAs accumulation involved insnoRNA processing, snoRNA transport to the nucleolus and ribosomebiogenesis. {ECO:0000269|PubMed:17636026}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDAH1_ZNHIT6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DDAH1_ZNHIT6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DDAH1 | CALM1, ELAVL1, IQCB1, PSMD10, MOV10, NXF1, DDAH2, BOLA3, LYRM4, APOOL, ATP5A1, LACE1, FGB, FSD1, TRIM25 | ZNHIT6 | ELAVL1, SIRT1, SMAD2, ZCCHC7, SKAP1, CARD8, LIPH, RUVBL1, TUBB, AHCYL2, IL13RA2, TGM5, F9, FAM46A, VWCE, CDC16, ASB3, PCDHGA5, IL17RA, PCDH20, PROZ, NUFIP1, ZNHIT3, ZNHIT6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDAH1_ZNHIT6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDAH1_ZNHIT6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DDAH1 | C0023895 | Liver diseases | 1 | CTD_human |