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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9493

FusionGeneSummary for DDAH1_WDR63

check button Fusion gene summary
Fusion gene informationFusion gene name: DDAH1_WDR63
Fusion gene ID: 9493
HgeneTgene
Gene symbol

DDAH1

WDR63

Gene ID

23576

126820

Gene namedimethylarginine dimethylaminohydrolase 1WD repeat domain 63
SynonymsDDAH|DDAH-1|DDAHI|HEL-S-16DIC3|NYD-SP29
Cytomap

1p22.3

1p22.3

Type of geneprotein-codingprotein-coding
DescriptionN(G),N(G)-dimethylarginine dimethylaminohydrolase 1NG, NG-dimethylarginine dimethylaminohydrolasedimethylargininase-1epididymis secretory protein Li 16WD repeat-containing protein 63testicular tissue protein Li 225testis development protein NYD-SP29 (NYD-SP29)
Modification date2018052320180523
UniProtAcc

O94760

Q8IWG1

Ensembl transtripts involved in fusion geneENST00000535924, ENST00000483110, 
ENST00000284031, ENST00000539042, 
ENST00000426972, ENST00000542148, 
ENST00000370596, ENST00000326813, 
ENST00000294664, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: DDAH1 [Title/Abstract] AND WDR63 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDAH1

GO:0000052

citrulline metabolic process

19663506

HgeneDDAH1

GO:0006527

arginine catabolic process

24895913

HgeneDDAH1

GO:0008285

negative regulation of cell proliferation

24895913

HgeneDDAH1

GO:0043116

negative regulation of vascular permeability

24895913

HgeneDDAH1

GO:1900038

negative regulation of cellular response to hypoxia

24895913


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-TS-A8AF-01ADDAH1chr1

86043667

-WDR63chr1

85587434

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000535924ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
5UTR-3CDSENST00000535924ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
5UTR-3CDSENST00000535924ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+
5UTR-3CDSENST00000483110ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
5UTR-3CDSENST00000483110ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
5UTR-3CDSENST00000483110ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000284031ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000284031ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000284031ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000539042ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000539042ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000539042ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000426972ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000426972ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000426972ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000542148ENST00000370596DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000542148ENST00000326813DDAH1chr1

86043667

-WDR63chr1

85587434

+
intron-3CDSENST00000542148ENST00000294664DDAH1chr1

86043667

-WDR63chr1

85587434

+

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FusionProtFeatures for DDAH1_WDR63


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDAH1

O94760

WDR63

Q8IWG1

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) andN(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.Has therefore a role in the regulation of nitric oxide generation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDAH1_WDR63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDAH1_WDR63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DDAH1CALM1, ELAVL1, IQCB1, PSMD10, MOV10, NXF1, DDAH2, BOLA3, LYRM4, APOOL, ATP5A1, LACE1, FGB, FSD1, TRIM25WDR63SHFM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDAH1_WDR63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDAH1_WDR63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDAH1C0023895Liver diseases1CTD_human