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Fusion gene ID: 9492 |
FusionGeneSummary for DDAH1_TRABD2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDAH1_TRABD2B | Fusion gene ID: 9492 | Hgene | Tgene | Gene symbol | DDAH1 | TRABD2B | Gene ID | 23576 | 388630 |
| Gene name | dimethylarginine dimethylaminohydrolase 1 | TraB domain containing 2B | |
| Synonyms | DDAH|DDAH-1|DDAHI|HEL-S-16 | TIKI2 | |
| Cytomap | 1p22.3 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1NG, NG-dimethylarginine dimethylaminohydrolasedimethylargininase-1epididymis secretory protein Li 16 | metalloprotease TIKI2TRAB domain-containing protein 2BUPF0632 protein Aheart, kidney and adipose-enriched transmembrane protein homolog | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | O94760 | A6NFA1 | |
| Ensembl transtripts involved in fusion gene | ENST00000535924, ENST00000483110, ENST00000284031, ENST00000539042, ENST00000426972, ENST00000542148, | ENST00000606738, ENST00000435576, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 2 X 4=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DDAH1 [Title/Abstract] AND TRABD2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDAH1 | GO:0000052 | citrulline metabolic process | 19663506 |
| Hgene | DDAH1 | GO:0006527 | arginine catabolic process | 24895913 |
| Hgene | DDAH1 | GO:0008285 | negative regulation of cell proliferation | 24895913 |
| Hgene | DDAH1 | GO:0043116 | negative regulation of vascular permeability | 24895913 |
| Hgene | DDAH1 | GO:1900038 | negative regulation of cellular response to hypoxia | 24895913 |
| Tgene | TRABD2B | GO:0006508 | proteolysis | 22726442 |
| Tgene | TRABD2B | GO:0030178 | negative regulation of Wnt signaling pathway | 22726442 |
| Tgene | TRABD2B | GO:0032461 | positive regulation of protein oligomerization | 22726442 |
| Tgene | TRABD2B | GO:1904808 | positive regulation of protein oxidation | 22726442 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-DM-A0XF-01A | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000535924 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-5UTR | ENST00000535924 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-3CDS | ENST00000483110 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-5UTR | ENST00000483110 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| In-frame | ENST00000284031 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| 5CDS-5UTR | ENST00000284031 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| In-frame | ENST00000539042 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| 5CDS-5UTR | ENST00000539042 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-3CDS | ENST00000426972 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-5UTR | ENST00000426972 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-3CDS | ENST00000542148 | ENST00000606738 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
| intron-5UTR | ENST00000542148 | ENST00000435576 | DDAH1 | chr1 | 85930426 | - | TRABD2B | chr1 | 48267291 | - |
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FusionProtFeatures for DDAH1_TRABD2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDAH1 | TRABD2B |
| Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) andN(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.Has therefore a role in the regulation of nitric oxide generation. | Metalloprotease that acts as a negative regulator of theWnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage,Wnt proteins become oxidized and form large disulfide-bondoligomers, leading to their inactivation. Able to cleave WNT3A,WNT5, but not WNT11. Required for head formation.{ECO:0000269|PubMed:22726442}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDAH1_TRABD2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDAH1_ENST00000284031_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_397aa MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALI TRPGAPSRRKEVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIY KRNERMGKRVMALLRENEDKICFFAFGAGHFLGNNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPS VTPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDSTTASPPPLPLQPTHSSGTAKPPFQLSDQLQQ >In-frame_DDAH1_ENST00000539042_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_397aa MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALI TRPGAPSRRKEVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIY KRNERMGKRVMALLRENEDKICFFAFGAGHFLGNNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPS VTPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDSTTASPPPLPLQPTHSSGTAKPPFQLSDQLQQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDAH1_ENST00000284031_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_1191nt ATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCGCTACCCGAGTCGCTCGGCCAGCACGCGCTG AGAAGCGCCAAGGGCGAGGAGGTGGACGTCGCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAGCTGGGGCTG CAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTGGCCGTGGTGTGCGAGGAGACGGCCCTCATC ACCCGACCCGGGGCGCCGAGCCGGAGGAAGGAGGTGCTGTTTGCCCTGAACCAAACCCTGCTGCAGCAGGAGAGTGTGCGGGCCGGGAGC CTGCAGGCCTCCTACACCACGGAGGACCTCATCAAGCACTACAACTGCGGAGACCTCAGCGCAGTCATCTTCAACCACGACACATCCCAG CTGCCCAACTTTATCAACACCACCCTCCCGCCACACGAGCAGGTGACGGCCCAGGAGATTGACAGCTACTTCCGCCAGGAGCTCATCTAC AAGAGGAATGAGCGCATGGGGAAGAGGGTCATGGCGCTTCTACGGGAGAACGAGGACAAGATCTGCTTCTTTGCCTTCGGAGCAGGTCAC TTTCTGGGGAACAACACAGTCATCGACATCCTGCGGCAGGCAGGGCTGGAGGTGGACCACACACCCGCCGGGCAGGCCATACACAGCCCT GCCCCCCAGAGCCCAGCGCCCTCTCCTGAGGGGACCTCGACGAGCCCGGCCCCAGTGACCCCAGCTGCCGCTGTCCCCGAAGCACCCTCT GTGACCCCCACCGCCCCACCAGAGGATGAGGATCCAGCCCTGTCCCCACACCTCCTGCTCCCCGACAGCCTCAGCCAGCTGGAGGAGTTT GGCCGGCAGAGGAAGTGGCACAAGAGGCAGAGCACACACCAGCGGCCGCGGCAGTTCAATGACCTCTGGGTCCGCATCGAGGACAGCACC ACCGCCTCACCACCCCCGCTGCCCCTGCAGCCCACCCACAGCTCGGGGACCGCCAAGCCCCCCTTCCAGCTTTCAGACCAGCTACAACAG CAGGACCCGCCAGGGCCCGCCAGCAGCTCGGCACCCACCCTGGGCCTTCTCCCCGCCATCGCCACCACCATCGCTGTCTGCTTCCTGCTG >In-frame_DDAH1_ENST00000539042_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_1191nt ATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCGCTACCCGAGTCGCTCGGCCAGCACGCGCTG AGAAGCGCCAAGGGCGAGGAGGTGGACGTCGCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAGCTGGGGCTG CAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTGGCCGTGGTGTGCGAGGAGACGGCCCTCATC ACCCGACCCGGGGCGCCGAGCCGGAGGAAGGAGGTGCTGTTTGCCCTGAACCAAACCCTGCTGCAGCAGGAGAGTGTGCGGGCCGGGAGC CTGCAGGCCTCCTACACCACGGAGGACCTCATCAAGCACTACAACTGCGGAGACCTCAGCGCAGTCATCTTCAACCACGACACATCCCAG CTGCCCAACTTTATCAACACCACCCTCCCGCCACACGAGCAGGTGACGGCCCAGGAGATTGACAGCTACTTCCGCCAGGAGCTCATCTAC AAGAGGAATGAGCGCATGGGGAAGAGGGTCATGGCGCTTCTACGGGAGAACGAGGACAAGATCTGCTTCTTTGCCTTCGGAGCAGGTCAC TTTCTGGGGAACAACACAGTCATCGACATCCTGCGGCAGGCAGGGCTGGAGGTGGACCACACACCCGCCGGGCAGGCCATACACAGCCCT GCCCCCCAGAGCCCAGCGCCCTCTCCTGAGGGGACCTCGACGAGCCCGGCCCCAGTGACCCCAGCTGCCGCTGTCCCCGAAGCACCCTCT GTGACCCCCACCGCCCCACCAGAGGATGAGGATCCAGCCCTGTCCCCACACCTCCTGCTCCCCGACAGCCTCAGCCAGCTGGAGGAGTTT GGCCGGCAGAGGAAGTGGCACAAGAGGCAGAGCACACACCAGCGGCCGCGGCAGTTCAATGACCTCTGGGTCCGCATCGAGGACAGCACC ACCGCCTCACCACCCCCGCTGCCCCTGCAGCCCACCCACAGCTCGGGGACCGCCAAGCCCCCCTTCCAGCTTTCAGACCAGCTACAACAG CAGGACCCGCCAGGGCCCGCCAGCAGCTCGGCACCCACCCTGGGCCTTCTCCCCGCCATCGCCACCACCATCGCTGTCTGCTTCCTGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDAH1_ENST00000284031_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_6660nt AGGAGCCGACGGGCGCTCGCAGGCTCAGCGCGCGCTGCCCGCGGCAGGACCCGGCCGCCTCCGCCGCCGCCGCCGCCCCTAAGCCTCCCG AAGCCATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCGCTACCCGAGTCGCTCGGCCAGCACG CGCTGAGAAGCGCCAAGGGCGAGGAGGTGGACGTCGCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAGCTGG GGCTGCAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTGGCCGTGGTGTGCGAGGAGACGGCCC TCATCACCCGACCCGGGGCGCCGAGCCGGAGGAAGGAGGTGCTGTTTGCCCTGAACCAAACCCTGCTGCAGCAGGAGAGTGTGCGGGCCG GGAGCCTGCAGGCCTCCTACACCACGGAGGACCTCATCAAGCACTACAACTGCGGAGACCTCAGCGCAGTCATCTTCAACCACGACACAT CCCAGCTGCCCAACTTTATCAACACCACCCTCCCGCCACACGAGCAGGTGACGGCCCAGGAGATTGACAGCTACTTCCGCCAGGAGCTCA TCTACAAGAGGAATGAGCGCATGGGGAAGAGGGTCATGGCGCTTCTACGGGAGAACGAGGACAAGATCTGCTTCTTTGCCTTCGGAGCAG GTCACTTTCTGGGGAACAACACAGTCATCGACATCCTGCGGCAGGCAGGGCTGGAGGTGGACCACACACCCGCCGGGCAGGCCATACACA GCCCTGCCCCCCAGAGCCCAGCGCCCTCTCCTGAGGGGACCTCGACGAGCCCGGCCCCAGTGACCCCAGCTGCCGCTGTCCCCGAAGCAC CCTCTGTGACCCCCACCGCCCCACCAGAGGATGAGGATCCAGCCCTGTCCCCACACCTCCTGCTCCCCGACAGCCTCAGCCAGCTGGAGG AGTTTGGCCGGCAGAGGAAGTGGCACAAGAGGCAGAGCACACACCAGCGGCCGCGGCAGTTCAATGACCTCTGGGTCCGCATCGAGGACA GCACCACCGCCTCACCACCCCCGCTGCCCCTGCAGCCCACCCACAGCTCGGGGACCGCCAAGCCCCCCTTCCAGCTTTCAGACCAGCTAC AACAGCAGGACCCGCCAGGGCCCGCCAGCAGCTCGGCACCCACCCTGGGCCTTCTCCCCGCCATCGCCACCACCATCGCTGTCTGCTTCC TGCTGCATAGCCTTGGGCCCTCCTGACCTCGGCCACCCCAAGTGGAGAAGCCAGAGAAATGACACAGGGGTCTTCGGCCACACCCAACTG CTCCTGCCACCACCTCCAGGGGGTGCCCAACACGTCGAGGGCAGTCCACATGGGATTGGCTAGACACTCTAGAGCTTTACTGTACCCAAG TTACATCTTCTTTTTTGTAGAAGGATCTTAATTTCCCATAGTGCTATGGGGCTCTTTTGTAAAATACGTGTCCATATTAAAAAAGAAAAA TGTATTTATTCTACCGATAAAACTATTCTTATGTGGCCTGTGTTATAACCCCCTAGCCCTAGTGCTGGCCCGGGAGGGGAACCCGGGACA TCAGTGACCTCCTGTGGACTGTGGCTCTGGACTGGCTTGCTCTTGGATCACCGAAGCCTCCTGGGTCTGGGTTTGGCTTCTCCGACTGTG GGGCCCTCAGCAGGAGGGGCAGGCAGGCAGGCTTAGCCTTTGTGAAGCTGGATTTGGGAGCCAGAGGTGTGAACGTTGGCCATCCTCCCC TCTGCTGGATGCACCCGCGGCCTGGGAAGATAATTTAGGAAAGAGAATGCTGCTATTGTGAAACCCCTGAGTGTCTATCTGGCCCTCCAG AGCTCTTGGTAAGTGTTTTCAACCAAAGCGCTGGGGTGGGGTGGGAGGTGGGATACTGGTGCTGAGGAAAGCAGTCCCCACCCCACAGAA CAAATGAATAAACTGAGATCCAGAGAGAACCAGGTGGGTAGCCCAAGGTCACACGGCAAGTGGGAGAGTGAGGACATAAATCCAGACCTC TCTGTTCTGGTGTCATGAATCCAGCTTGGGTTAAAGGAGAGGCTGTTGAAGTCCTGGCTAAATGGATTGAGCTGGGCCGAGGGACTGGAG TGGGCACAGGAGGGCAGTTTTAGAGACAGGGGCTTAGGCCTCACATGATGTTAATAGTAATGAGAGCTGCCATTTTTCCAAAGCCTGCAG CGTGGCAAGCACTTTGCACACTTGCTTCACTGATTCTTGCGCTAGTTCTGTGAGATGTGACTATCCCCATTTCACAGATGAGGAAACTGA GCCCCCCAAAGAGGCGAAGGGACTTGCTGAAGATCCCCCAGCCAGGATGTGGCCCCAGATCAGTGTGATGCAAAACAATTCCTGCCTCCT GTTCCCTGTTCTGCCACGTTCTCTCTGCAAGGGAGCAGATCTCACCCAAACTGGGGCCAGCACAAGCTTTCACTCCACCAAGAAACCTTT TGGCCGGCTGCTTATGTTGACCCCTCTGGCCAAAGGGCTCTGGCAACTGCATGTGCCATGTGTCGCATGTCCTGACTTGCCAGATCTTGG AGCCCACGAGAAGCTTTCCTGCCAAATCAAAGGCTGAGAGGTGGGCACAGCTGTGGGGCACCTGGGGAGGCACAGCAGCCAAGTGGGGAG GCAGGTGACAGGGACTCCGAGAGACTTTAGCCCCTCGGCTCCTCAAGGTGGTGGTTGAGGAGACAGAGGACCCAGGTGGGCTAACTCCCA CCTGGGAGGCCTGAAACCCTATGGGGCAGGTGCCTCAGTAATTACAGAGTCCTGGAACCTGACAGCAGAAAGGACCCTTCACTTGATGGA TAATAGTAACAGTAGGAGGAATAATAAGGCCCACAGAGAGGAGACACTTCTCCAAGGCTGCACAGCCGGGTGGGCCTGCTGACTCCCAGC CCAGTGCACCCCAACTTTATAGCTTCGTGGGTTTCCCTGGCAGGCTTGATGGCAGCTAATTGGCCCCAGTGCCATCTTGCCCAGCTTGGC AGCTATCTCCCTTCTGAGACGGCAAGTTCTGGGCAGCTCATGGGATGGTCAGGAGTCCCACGGGCATCTTGGCAGGCAGCTGAATTCTTT ACAGCTCAGCCCTGATGGACGTGTTTGAGCTTGAGACCTGGCAGGAGACTGGAGCTCTGCCTTAGAGGGCCCAGCCAGCCCTGTGGGCAC CATGCTCTAAACTGAACTTGACCTCAATCCAGGCTGGAGTTGGTTTATCCTTGGCAAAAATGTGACTTCCTATTTCTGAGCGGGAAGGGG CTTAGCTGACTTATAAAGCAGGCTCAGAAGTTGGACATCAAACGGATCGTGCAGTGCACTATTTGGATGAGATAAGTGTAAAGGAATTAG AAGCACACAGGCCAGATTCCTCTCTGTTTGGGGCAGAGTATGGCGTGAGACGTATTGAGATGGAGCTTGAGGTTAATTAAAGATGAAGCA TTTGGGTAAACAGTCCAGGCACCTGACCGTGTGCCCAGATCTGTGCCAGGCACTGAGCCAAGAAGGTAAATTAATGCAGCTTGTAATTAC TGAGCACATGCAATGCCAGGCTCTGTATTAGAGCTGAATCTAACCACTCTCCTTGGCCCAGAGGAACTCATTATCAAGATGGGACAAGCA GTGCAATGCTAGATTACGTCGTCCTGGCCCCTAACTTCAGGAAGATTCAGCCTTAGTCTTTCCCAGATCCCTCCTCTGGGCATATTAGGG GATCCTAAACTCTCCCTTACCCTAATTCAAGTGTTTAAAGAAAGATGGCTAGACTAACCGATGGAGTAGACATGTACCTACAGGAGAGCA AGAGCCAATGTGGTCAGACATCTGTTGCCAAAGTTCACTGATCTCTGAGGACCACCAGCTGGCCAGGGTCTGAAATGAACTCAACTTGCT GACTTATGACCCAAAAGACTTGAGGCACATATGCAGGAATCTGCATGTCTGGGGCACTTGAATTCTCTCATCCTGGGCCAGAGAACCACC ATTCCATAAGCAGCAACCCACACCTTTGACACGATCTATCCACCACTAACTGACATTTCTTCCAGAAACGTTCTTTGTGCCCAGCCTCAT AAAATGCTCCTGTTGCTCTGAGAAATTTGTGTGCACTTCTTAGACTTTTCTGTTTGACTGTGAGGCAGGCAGGAAAGATGAAAGGTCTGA GACCCAGCAGGTAAAGTGATCTGCTTAAGGTCGGGCAGCATGTTATTGTGGCCCTGGGTCCTCTACCTCTCACGAAAGCTGACTGTGTGA TGAAGGGCTCTCTGGGGCATGTTGGAATGGCCATGTCCCCAGGTCTTCCTCCAGTGGTGGGTCTGATGCACCAGCAGCCAGATGAAGACA GGGAGAGCCCTGTCATCCACAGTGGAGGGAGAAGAATCAGGCTGCCAGGGAGCTGCAAAGGGCTGCTGAGGATGCCTCCAGTCCTGAGAG TCAAAGATCTGGGATCTAGGAAGCATGGAACCTTGTGCTGGTTATGAACAAATTTGTCCTTGCATTGAAAGACCCTAAGCATATTTTCTT CATGCTAAATAATGTGTTATCTACAACTTCCTGGCCTCGGCTAGACCTGGACAAGCCTAGGTGCTCAGGCCCCTTGTCCCACTTGCCTAA TCTCCAGCCCAGGGCCATTGTCACAGTGGATCCCAAAGAGGAGGGAAAGTCCTTCTACCAAAAGGAAAGTCTATTGAAAATGCTGTGAAG GACAAGAGAAGTTCTCCAGGGAATTGCAGCTTTGATGGCATCCTGTGTGGCAGACAGCAGAATTGGGGCTGGTGATAGTTTTTCAGTGAC TGTGAGATAAGAACCAGAGTCCTCAGCCTCACCCTGAAGTGTCCGCTAGACCCTTCGTGACCCAACCCTGCTGACCAGCCACGTCTCTCA TGTCTCTTACCCTGTGCCTGGCCAGCGTGATGTGCAGTCATCTCTAGAATAGACAGGATGTTTCACACATGCTGCTCCCTACCCCTGGAA ACTCCCTTCTCTCCCCTGTAACTGCTCATCCATTGAGGATCAACACAGATAGCACTTCCTCCAGGAAGCCCCCTCCCATTCCTTTGTGCT TTCTTAGCATCTATCACAATACCCACTGCCCAGTGTTGTGACTATCTAGTGTGTATCTGCTCCTCTCGGACTGTGAGCAGCTTAATGGCA GGGGTCATGTAAATTTGTTTTTGTACCCTCATCTGACACAAAGGTGGTGCTCAACAGATGTGTAGAGAGAGAAAGGAAGGGAAGGAAGCT GAAGGAAGGGGAGGAAGAAAGGAATGAAGGCAGAAAAGAAGGAGAGAGGCAGACCTTAGTTCCACCAGTGGCATAATTTCCACCAAGCCA AAGCTGTCTGGGGATGGCCCGGAGCCCCCAAGGGTGGCAGGTTTCCCATCGGGAGAGGTGTTTGAGCAGGGGCAGTGTGCCCACTGGCTG AAGAAGTGGTAGGAGAGTTGACATCTTGCCAAGGGCCTGGTGTAGATGACATTGAGGGTCCCTCCTGGCTCTGCAATGATCAAGTTCTAT GAACATTGTTATTTTTCCAGAAATTCATCTGAGCAGCCAAAAAAAATCACCCCGCTGGCTGTCTAAACCAGTAAGGTTCAGGAATAAGTC CAGCCTCCCCACTCCACCCACAACCACCACCACCCCTCACAGCGCCCCCTTCAATGACCCAGCTGGGCTTGACTGCTGCCTTTGGGTGGG GGAACTTCTGAAAGGTGGAGGAGGAGTGAACTGGAACCCAGGCCTGCAGCCCAGCCCAGAGCTCCTTCCCGCTCTGCCCCACTCCCTGAC CCCAGGGGAGGAAAGGGTTCACGAGAACTGATTGACCCCCTACTTGGCTCTTTCCAGGGAGCATCGGCTATCCTCACCCTTTCTCCAAGT GGGAGCTGGGCTCTTCCTTTCCGGAGATACTCTGGATACTCCTTCACTTTGCTGGATGACCTTGGGCAAGTTCCTGTCCCTCTCTGAGCC TTCACTTCCTCATCTGTCAAATGAAGACCTTGATTCCTGCCTGGGCAGTTCTAGGGCTGGAGGGCAGGGGTGACATGGACAATCTTGGGC CTCCATGGAGATGAGGTGCTTGGCTTTCTTCCCAGGACCCACAGGCTGCCATGGGATTGAAAGCATGTGGAGGTGGGAAAGGTGACAGAG TAGCATGCCTCCAAGGCCCCCTTCATCCCAGTCCTGCTGTGGGGAAAGTGGGCTTTGAACGGGATCCAAGTCTAAGATGTTTCCGGTGAG CTGCCAGGGACAAAGGGCTCTCAGACATCTTGGGTCCCCAGTGGCTGGGGTGGGCAGGGGCTGATTCAGCCAAAGGAGGCTCTAGCCCAG AACAGAGGAAGCCAGAGCCCCTGCCCCATTCTTGAGCCTCACAGAGCTTGTCCCCGAGTTGATTCACTGTGCAACACAGGCTTCAGATTC ATGTATTTGAAAGGTATTCATGATGTTGTTCTCTTATCACCTCTGCCCCTCACCTCTGTGAATTATCATGAAGAGTCCTTTAAGAGTATA AATAGAAGACAAAGAAAGATGCTATTAATGTTATTTTGCCAAAAATATTTTTGTAGCATAATATATTAATAAAAGATATTATGAATTCAA >In-frame_DDAH1_ENST00000539042_chr1_85930426_-_TRABD2B_ENST00000606738_chr1_48267291_-_6664nt CAAGAGGAGCCGACGGGCGCTCGCAGGCTCAGCGCGCGCTGCCCGCGGCAGGACCCGGCCGCCTCCGCCGCCGCCGCCGCCCCTAAGCCT CCCGAAGCCATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCGCTACCCGAGTCGCTCGGCCAG CACGCGCTGAGAAGCGCCAAGGGCGAGGAGGTGGACGTCGCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAG CTGGGGCTGCAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTGGCCGTGGTGTGCGAGGAGACG GCCCTCATCACCCGACCCGGGGCGCCGAGCCGGAGGAAGGAGGTGCTGTTTGCCCTGAACCAAACCCTGCTGCAGCAGGAGAGTGTGCGG GCCGGGAGCCTGCAGGCCTCCTACACCACGGAGGACCTCATCAAGCACTACAACTGCGGAGACCTCAGCGCAGTCATCTTCAACCACGAC ACATCCCAGCTGCCCAACTTTATCAACACCACCCTCCCGCCACACGAGCAGGTGACGGCCCAGGAGATTGACAGCTACTTCCGCCAGGAG CTCATCTACAAGAGGAATGAGCGCATGGGGAAGAGGGTCATGGCGCTTCTACGGGAGAACGAGGACAAGATCTGCTTCTTTGCCTTCGGA GCAGGTCACTTTCTGGGGAACAACACAGTCATCGACATCCTGCGGCAGGCAGGGCTGGAGGTGGACCACACACCCGCCGGGCAGGCCATA CACAGCCCTGCCCCCCAGAGCCCAGCGCCCTCTCCTGAGGGGACCTCGACGAGCCCGGCCCCAGTGACCCCAGCTGCCGCTGTCCCCGAA GCACCCTCTGTGACCCCCACCGCCCCACCAGAGGATGAGGATCCAGCCCTGTCCCCACACCTCCTGCTCCCCGACAGCCTCAGCCAGCTG GAGGAGTTTGGCCGGCAGAGGAAGTGGCACAAGAGGCAGAGCACACACCAGCGGCCGCGGCAGTTCAATGACCTCTGGGTCCGCATCGAG GACAGCACCACCGCCTCACCACCCCCGCTGCCCCTGCAGCCCACCCACAGCTCGGGGACCGCCAAGCCCCCCTTCCAGCTTTCAGACCAG CTACAACAGCAGGACCCGCCAGGGCCCGCCAGCAGCTCGGCACCCACCCTGGGCCTTCTCCCCGCCATCGCCACCACCATCGCTGTCTGC TTCCTGCTGCATAGCCTTGGGCCCTCCTGACCTCGGCCACCCCAAGTGGAGAAGCCAGAGAAATGACACAGGGGTCTTCGGCCACACCCA ACTGCTCCTGCCACCACCTCCAGGGGGTGCCCAACACGTCGAGGGCAGTCCACATGGGATTGGCTAGACACTCTAGAGCTTTACTGTACC CAAGTTACATCTTCTTTTTTGTAGAAGGATCTTAATTTCCCATAGTGCTATGGGGCTCTTTTGTAAAATACGTGTCCATATTAAAAAAGA AAAATGTATTTATTCTACCGATAAAACTATTCTTATGTGGCCTGTGTTATAACCCCCTAGCCCTAGTGCTGGCCCGGGAGGGGAACCCGG GACATCAGTGACCTCCTGTGGACTGTGGCTCTGGACTGGCTTGCTCTTGGATCACCGAAGCCTCCTGGGTCTGGGTTTGGCTTCTCCGAC TGTGGGGCCCTCAGCAGGAGGGGCAGGCAGGCAGGCTTAGCCTTTGTGAAGCTGGATTTGGGAGCCAGAGGTGTGAACGTTGGCCATCCT CCCCTCTGCTGGATGCACCCGCGGCCTGGGAAGATAATTTAGGAAAGAGAATGCTGCTATTGTGAAACCCCTGAGTGTCTATCTGGCCCT CCAGAGCTCTTGGTAAGTGTTTTCAACCAAAGCGCTGGGGTGGGGTGGGAGGTGGGATACTGGTGCTGAGGAAAGCAGTCCCCACCCCAC AGAACAAATGAATAAACTGAGATCCAGAGAGAACCAGGTGGGTAGCCCAAGGTCACACGGCAAGTGGGAGAGTGAGGACATAAATCCAGA CCTCTCTGTTCTGGTGTCATGAATCCAGCTTGGGTTAAAGGAGAGGCTGTTGAAGTCCTGGCTAAATGGATTGAGCTGGGCCGAGGGACT GGAGTGGGCACAGGAGGGCAGTTTTAGAGACAGGGGCTTAGGCCTCACATGATGTTAATAGTAATGAGAGCTGCCATTTTTCCAAAGCCT GCAGCGTGGCAAGCACTTTGCACACTTGCTTCACTGATTCTTGCGCTAGTTCTGTGAGATGTGACTATCCCCATTTCACAGATGAGGAAA CTGAGCCCCCCAAAGAGGCGAAGGGACTTGCTGAAGATCCCCCAGCCAGGATGTGGCCCCAGATCAGTGTGATGCAAAACAATTCCTGCC TCCTGTTCCCTGTTCTGCCACGTTCTCTCTGCAAGGGAGCAGATCTCACCCAAACTGGGGCCAGCACAAGCTTTCACTCCACCAAGAAAC CTTTTGGCCGGCTGCTTATGTTGACCCCTCTGGCCAAAGGGCTCTGGCAACTGCATGTGCCATGTGTCGCATGTCCTGACTTGCCAGATC TTGGAGCCCACGAGAAGCTTTCCTGCCAAATCAAAGGCTGAGAGGTGGGCACAGCTGTGGGGCACCTGGGGAGGCACAGCAGCCAAGTGG GGAGGCAGGTGACAGGGACTCCGAGAGACTTTAGCCCCTCGGCTCCTCAAGGTGGTGGTTGAGGAGACAGAGGACCCAGGTGGGCTAACT CCCACCTGGGAGGCCTGAAACCCTATGGGGCAGGTGCCTCAGTAATTACAGAGTCCTGGAACCTGACAGCAGAAAGGACCCTTCACTTGA TGGATAATAGTAACAGTAGGAGGAATAATAAGGCCCACAGAGAGGAGACACTTCTCCAAGGCTGCACAGCCGGGTGGGCCTGCTGACTCC CAGCCCAGTGCACCCCAACTTTATAGCTTCGTGGGTTTCCCTGGCAGGCTTGATGGCAGCTAATTGGCCCCAGTGCCATCTTGCCCAGCT TGGCAGCTATCTCCCTTCTGAGACGGCAAGTTCTGGGCAGCTCATGGGATGGTCAGGAGTCCCACGGGCATCTTGGCAGGCAGCTGAATT CTTTACAGCTCAGCCCTGATGGACGTGTTTGAGCTTGAGACCTGGCAGGAGACTGGAGCTCTGCCTTAGAGGGCCCAGCCAGCCCTGTGG GCACCATGCTCTAAACTGAACTTGACCTCAATCCAGGCTGGAGTTGGTTTATCCTTGGCAAAAATGTGACTTCCTATTTCTGAGCGGGAA GGGGCTTAGCTGACTTATAAAGCAGGCTCAGAAGTTGGACATCAAACGGATCGTGCAGTGCACTATTTGGATGAGATAAGTGTAAAGGAA TTAGAAGCACACAGGCCAGATTCCTCTCTGTTTGGGGCAGAGTATGGCGTGAGACGTATTGAGATGGAGCTTGAGGTTAATTAAAGATGA AGCATTTGGGTAAACAGTCCAGGCACCTGACCGTGTGCCCAGATCTGTGCCAGGCACTGAGCCAAGAAGGTAAATTAATGCAGCTTGTAA TTACTGAGCACATGCAATGCCAGGCTCTGTATTAGAGCTGAATCTAACCACTCTCCTTGGCCCAGAGGAACTCATTATCAAGATGGGACA AGCAGTGCAATGCTAGATTACGTCGTCCTGGCCCCTAACTTCAGGAAGATTCAGCCTTAGTCTTTCCCAGATCCCTCCTCTGGGCATATT AGGGGATCCTAAACTCTCCCTTACCCTAATTCAAGTGTTTAAAGAAAGATGGCTAGACTAACCGATGGAGTAGACATGTACCTACAGGAG AGCAAGAGCCAATGTGGTCAGACATCTGTTGCCAAAGTTCACTGATCTCTGAGGACCACCAGCTGGCCAGGGTCTGAAATGAACTCAACT TGCTGACTTATGACCCAAAAGACTTGAGGCACATATGCAGGAATCTGCATGTCTGGGGCACTTGAATTCTCTCATCCTGGGCCAGAGAAC CACCATTCCATAAGCAGCAACCCACACCTTTGACACGATCTATCCACCACTAACTGACATTTCTTCCAGAAACGTTCTTTGTGCCCAGCC TCATAAAATGCTCCTGTTGCTCTGAGAAATTTGTGTGCACTTCTTAGACTTTTCTGTTTGACTGTGAGGCAGGCAGGAAAGATGAAAGGT CTGAGACCCAGCAGGTAAAGTGATCTGCTTAAGGTCGGGCAGCATGTTATTGTGGCCCTGGGTCCTCTACCTCTCACGAAAGCTGACTGT GTGATGAAGGGCTCTCTGGGGCATGTTGGAATGGCCATGTCCCCAGGTCTTCCTCCAGTGGTGGGTCTGATGCACCAGCAGCCAGATGAA GACAGGGAGAGCCCTGTCATCCACAGTGGAGGGAGAAGAATCAGGCTGCCAGGGAGCTGCAAAGGGCTGCTGAGGATGCCTCCAGTCCTG AGAGTCAAAGATCTGGGATCTAGGAAGCATGGAACCTTGTGCTGGTTATGAACAAATTTGTCCTTGCATTGAAAGACCCTAAGCATATTT TCTTCATGCTAAATAATGTGTTATCTACAACTTCCTGGCCTCGGCTAGACCTGGACAAGCCTAGGTGCTCAGGCCCCTTGTCCCACTTGC CTAATCTCCAGCCCAGGGCCATTGTCACAGTGGATCCCAAAGAGGAGGGAAAGTCCTTCTACCAAAAGGAAAGTCTATTGAAAATGCTGT GAAGGACAAGAGAAGTTCTCCAGGGAATTGCAGCTTTGATGGCATCCTGTGTGGCAGACAGCAGAATTGGGGCTGGTGATAGTTTTTCAG TGACTGTGAGATAAGAACCAGAGTCCTCAGCCTCACCCTGAAGTGTCCGCTAGACCCTTCGTGACCCAACCCTGCTGACCAGCCACGTCT CTCATGTCTCTTACCCTGTGCCTGGCCAGCGTGATGTGCAGTCATCTCTAGAATAGACAGGATGTTTCACACATGCTGCTCCCTACCCCT GGAAACTCCCTTCTCTCCCCTGTAACTGCTCATCCATTGAGGATCAACACAGATAGCACTTCCTCCAGGAAGCCCCCTCCCATTCCTTTG TGCTTTCTTAGCATCTATCACAATACCCACTGCCCAGTGTTGTGACTATCTAGTGTGTATCTGCTCCTCTCGGACTGTGAGCAGCTTAAT GGCAGGGGTCATGTAAATTTGTTTTTGTACCCTCATCTGACACAAAGGTGGTGCTCAACAGATGTGTAGAGAGAGAAAGGAAGGGAAGGA AGCTGAAGGAAGGGGAGGAAGAAAGGAATGAAGGCAGAAAAGAAGGAGAGAGGCAGACCTTAGTTCCACCAGTGGCATAATTTCCACCAA GCCAAAGCTGTCTGGGGATGGCCCGGAGCCCCCAAGGGTGGCAGGTTTCCCATCGGGAGAGGTGTTTGAGCAGGGGCAGTGTGCCCACTG GCTGAAGAAGTGGTAGGAGAGTTGACATCTTGCCAAGGGCCTGGTGTAGATGACATTGAGGGTCCCTCCTGGCTCTGCAATGATCAAGTT CTATGAACATTGTTATTTTTCCAGAAATTCATCTGAGCAGCCAAAAAAAATCACCCCGCTGGCTGTCTAAACCAGTAAGGTTCAGGAATA AGTCCAGCCTCCCCACTCCACCCACAACCACCACCACCCCTCACAGCGCCCCCTTCAATGACCCAGCTGGGCTTGACTGCTGCCTTTGGG TGGGGGAACTTCTGAAAGGTGGAGGAGGAGTGAACTGGAACCCAGGCCTGCAGCCCAGCCCAGAGCTCCTTCCCGCTCTGCCCCACTCCC TGACCCCAGGGGAGGAAAGGGTTCACGAGAACTGATTGACCCCCTACTTGGCTCTTTCCAGGGAGCATCGGCTATCCTCACCCTTTCTCC AAGTGGGAGCTGGGCTCTTCCTTTCCGGAGATACTCTGGATACTCCTTCACTTTGCTGGATGACCTTGGGCAAGTTCCTGTCCCTCTCTG AGCCTTCACTTCCTCATCTGTCAAATGAAGACCTTGATTCCTGCCTGGGCAGTTCTAGGGCTGGAGGGCAGGGGTGACATGGACAATCTT GGGCCTCCATGGAGATGAGGTGCTTGGCTTTCTTCCCAGGACCCACAGGCTGCCATGGGATTGAAAGCATGTGGAGGTGGGAAAGGTGAC AGAGTAGCATGCCTCCAAGGCCCCCTTCATCCCAGTCCTGCTGTGGGGAAAGTGGGCTTTGAACGGGATCCAAGTCTAAGATGTTTCCGG TGAGCTGCCAGGGACAAAGGGCTCTCAGACATCTTGGGTCCCCAGTGGCTGGGGTGGGCAGGGGCTGATTCAGCCAAAGGAGGCTCTAGC CCAGAACAGAGGAAGCCAGAGCCCCTGCCCCATTCTTGAGCCTCACAGAGCTTGTCCCCGAGTTGATTCACTGTGCAACACAGGCTTCAG ATTCATGTATTTGAAAGGTATTCATGATGTTGTTCTCTTATCACCTCTGCCCCTCACCTCTGTGAATTATCATGAAGAGTCCTTTAAGAG TATAAATAGAAGACAAAGAAAGATGCTATTAATGTTATTTTGCCAAAAATATTTTTGTAGCATAATATATTAATAAAAGATATTATGAAT |
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FusionGenePPI for DDAH1_TRABD2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDAH1 | CALM1, ELAVL1, IQCB1, PSMD10, MOV10, NXF1, DDAH2, BOLA3, LYRM4, APOOL, ATP5A1, LACE1, FGB, FSD1, TRIM25 | TRABD2B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDAH1_TRABD2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDAH1_TRABD2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DDAH1 | C0023895 | Liver diseases | 1 | CTD_human |
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