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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9480

FusionGeneSummary for DCUN1D4_PTPRT

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D4_PTPRT
Fusion gene ID: 9480
HgeneTgene
Gene symbol

DCUN1D4

PTPRT

Gene ID

23142

11122

Gene namedefective in cullin neddylation 1 domain containing 4protein tyrosine phosphatase, receptor type T
Synonyms-RPTPrho
Cytomap

4q12

20q12-q13.11

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho
Modification date2018052320180519
UniProtAcc

Q92564

O14522

Ensembl transtripts involved in fusion geneENST00000381441, ENST00000334635, 
ENST00000513800, ENST00000381437, 
ENST00000451288, 		ENST00000373184, 
ENST00000373187, ENST00000356100, 
ENST00000373190, ENST00000373193, 
ENST00000373198, ENST00000373201, 
ENST00000485499, 
Fusion gene scores* DoF score7 X 7 X 5=24510 X 8 X 6=480
# samples 710
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D4 [Title/Abstract] AND PTPRT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRT

GO:0006470

protein dephosphorylation

16973135

TgenePTPRT

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

18644975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A1Q9-06ADCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000381441ENST00000373184DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000373187DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000356100DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000373190DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000373193DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000373198DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000381441ENST00000373201DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-intronENST00000381441ENST00000485499DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373184DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373187DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000356100DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373190DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373193DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373198DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000334635ENST00000373201DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
5CDS-intronENST00000334635ENST00000485499DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373184DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373187DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000356100DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373190DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373193DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373198DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-3CDSENST00000513800ENST00000373201DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
intron-intronENST00000513800ENST00000485499DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373184DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373187DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000356100DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373190DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373193DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373198DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000381437ENST00000373201DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
5CDS-intronENST00000381437ENST00000485499DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373184DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373187DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000356100DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373190DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373193DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373198DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
Frame-shiftENST00000451288ENST00000373201DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-
5CDS-intronENST00000451288ENST00000485499DCUN1D4chr4

52777340

+PTPRTchr20

41101202

-

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FusionProtFeatures for DCUN1D4_PTPRT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D4

Q92564

PTPRT

O14522


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCUN1D4_PTPRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCUN1D4_PTPRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCUN1D4VAV2, ELAVL1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2M, BUD31, TOP3A, CAND1, RBX1, RNF7, ARL4C, MSRB3, TRIM25PTPRTCUL3, EGFR, ERBB2, ERBB4, ATP2A2, PHKA1, PHKB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCUN1D4_PTPRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCUN1D4_PTPRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource