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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9479

FusionGeneSummary for DCUN1D4_IKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D4_IKZF1
Fusion gene ID: 9479
HgeneTgene
Gene symbol

DCUN1D4

IKZF1

Gene ID

23142

10320

Gene namedefective in cullin neddylation 1 domain containing 4IKAROS family zinc finger 1
Synonyms-CVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1
Cytomap

4q12

7p12.2

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4DNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)
Modification date2018052320180527
UniProtAcc

Q92564

Q13422

Ensembl transtripts involved in fusion geneENST00000381441, ENST00000334635, 
ENST00000513800, ENST00000381437, 
ENST00000451288, 		ENST00000440768, 
ENST00000359197, ENST00000343574, 
ENST00000331340, ENST00000349824, 
ENST00000357364, ENST00000346667, 
ENST00000438033, ENST00000439701, 
ENST00000413698, ENST00000492782, 
Fusion gene scores* DoF score7 X 7 X 5=2456 X 6 X 3=108
# samples 76
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D4 [Title/Abstract] AND IKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-IE-A4EJ-01ADCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381441ENST00000440768DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000381441ENST00000359197DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000343574DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000331340DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000349824DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000357364DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000346667DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000438033DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000439701DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000413698DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381441ENST00000492782DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000334635ENST00000440768DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000334635ENST00000359197DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000343574DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000331340DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000349824DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000357364DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000346667DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000438033DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000439701DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000413698DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000334635ENST00000492782DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-3CDSENST00000513800ENST00000440768DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-3CDSENST00000513800ENST00000359197DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000343574DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000331340DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000349824DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000357364DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000346667DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000438033DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000439701DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000413698DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
intron-intronENST00000513800ENST00000492782DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000381437ENST00000440768DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000381437ENST00000359197DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000343574DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000331340DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000349824DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000357364DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000346667DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000438033DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000439701DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000413698DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000381437ENST00000492782DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000451288ENST00000440768DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
Frame-shiftENST00000451288ENST00000359197DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000343574DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000331340DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000349824DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000357364DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000346667DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000438033DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000439701DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000413698DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+
5CDS-intronENST00000451288ENST00000492782DCUN1D4chr4

52758017

+IKZF1chr7

50444231

+

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FusionProtFeatures for DCUN1D4_IKZF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D4

Q92564

IKZF1

Q13422

Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCUN1D4_IKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCUN1D4_IKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCUN1D4VAV2, ELAVL1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2M, BUD31, TOP3A, CAND1, RBX1, RNF7, ARL4C, MSRB3, TRIM25IKZF1UBE2I, AP2M1, CTBP1, RBBP8, SIN3A, NCOR2, TBP, GTF2B, SIN3B, HDAC1, CHD4, HDAC2, HDAC4, HDAC5, HDAC7, HDAC3, IKZF4, IKZF5, IKZF2, GATA1, SMARCE1, NUDT21, CSNK1G1, CDK2AP2, IKZF3, RBBP4, CHD3, SMARCA4, NOTCH1, HDAC11, TDG, CRBN, ANKRD11, PRKAB2, BYSL, CKS1B, CTBP2, DCX, DDX6, FGF12, PIN1, PSMA1, PSMA4, RAD51D, SDCBP, SNRPF, DYRK2, AP1M1, MTA1, WTAP, MORF4L2, RWDD2B, IKZF1, MCRS1, MAD2L2, GLRX3, NEK6, MORF4L1, PNKP, SNW1, ISCU, LSM4, FAM50B, ZNF581, SYT17, C1orf109, C19orf66, LMO3, CBX8, SH2D4A, KIF9, GMCL1P1, AEN, C8orf33, SCNM1, NOC4L, ARMC7, FAM214B, FAM161A, SPATC1L, FRMD6, ZNF417, ZMAT2, ALKBH3, CEP57L1, C1orf174, FAM74A4, SH3BP2, MPPED2, NFATC2, NFATC1, MIB2, KLHDC10, POC1A, FOXK2, FOXK1, WDR76, APPBP2, ANKRD27, ZMYND19, KLHDC3, NFS1, MTA3, CUL2, BTBD1, HSD17B4, WDR26, GATAD2A, MKLN1, GATAD2B, RMND5A, RANBP10, MTA2, ARMC8, GALC, POTEI


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCUN1D4_IKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCUN1D4_IKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIKZF1C0009324Ulcerative Colitis1CTD_human
TgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIKZF1C0024299Lymphoma1CTD_human
TgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT