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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9477

FusionGeneSummary for DCUN1D4_EML4

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D4_EML4
Fusion gene ID: 9477
HgeneTgene
Gene symbol

DCUN1D4

EML4

Gene ID

23142

27436

Gene namedefective in cullin neddylation 1 domain containing 4echinoderm microtubule associated protein like 4
Synonyms-C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120
Cytomap

4q12

2p21

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4echinoderm microtubule-associated protein-like 4restrictedly overexpressed proliferation-associated proteinropp 120
Modification date2018052320180523
UniProtAcc

Q92564

Q9HC35

Ensembl transtripts involved in fusion geneENST00000381441, ENST00000334635, 
ENST00000513800, ENST00000381437, 
ENST00000451288, 
ENST00000318522, 
ENST00000402711, ENST00000482660, 
ENST00000401738, ENST00000453191, 
Fusion gene scores* DoF score7 X 7 X 5=2457 X 9 X 4=252
# samples 79
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D4 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE150925DCUN1D4chr4

52779981

+EML4chr2

42556033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000381441ENST00000318522DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-3CDSENST00000381441ENST00000402711DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381441ENST00000482660DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381441ENST00000401738DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381441ENST00000453191DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-3CDSENST00000334635ENST00000318522DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-3CDSENST00000334635ENST00000402711DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000334635ENST00000482660DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000334635ENST00000401738DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000334635ENST00000453191DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-3CDSENST00000513800ENST00000318522DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-3CDSENST00000513800ENST00000402711DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000513800ENST00000482660DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000513800ENST00000401738DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000513800ENST00000453191DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-3CDSENST00000381437ENST00000318522DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-3CDSENST00000381437ENST00000402711DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381437ENST00000482660DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381437ENST00000401738DCUN1D4chr4

52779981

+EML4chr2

42556033

+
3UTR-intronENST00000381437ENST00000453191DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-3CDSENST00000451288ENST00000318522DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-3CDSENST00000451288ENST00000402711DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000451288ENST00000482660DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000451288ENST00000401738DCUN1D4chr4

52779981

+EML4chr2

42556033

+
intron-intronENST00000451288ENST00000453191DCUN1D4chr4

52779981

+EML4chr2

42556033

+

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FusionProtFeatures for DCUN1D4_EML4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D4

Q92564

EML4

Q9HC35


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCUN1D4_EML4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCUN1D4_EML4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCUN1D4_EML4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCUN1D4_EML4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
TgeneEML4C0027627Neoplasm Metastasis2CTD_human
TgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneEML4C0006118Brain Neoplasms1CTD_human